Runx3 runt related transcription factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Runx3provided by MGI
Official Full Name: runt related transcription factor 3provided by MGI
Primary source: MGI:MGI:102672
See related: Ensembl:ENSMUSG00000070691 AllianceGenome:MGI:102672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rx3; AML2; Cbfa3; Pebp2a3
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of epithelial cell proliferation; negative regulation of transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Acts upstream of or within several processes, including chondrocyte differentiation; hair follicle morphogenesis; and positive regulation of extrinsic apoptotic signaling pathway. Located in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma and inflammatory bowel disease. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 11.1), thymus adult (RPKM 6.0) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 67.19 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (134847956..134905301)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (135120645..135177990)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence.
Title: Runx3 Restoration Regresses K-Ras-Activated Mouse Lung Cancers and Inhibits Recurrence.
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Title: Prox2 and Runx3 vagal sensory neurons regulate esophageal motility.
Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.
Title: Runx1/3-driven adaptive endoplasmic reticulum stress pathways contribute to neurofibromagenesis.
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3beta-FBXW7 cascade.
Title: RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death.
Title: Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death.
MicroRNA-19a Inhibition Directly and Indirectly Ameliorates Th2 Airway Inflammation in Asthma by Targeting RUNX3.
Title: MicroRNA-19a Inhibition Directly and Indirectly Ameliorates Th2 Airway Inflammation in Asthma by Targeting RUNX3.
Genetically encoded Runx3 and CD4[+] intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy.
Title: Genetically encoded Runx3 and CD4(+) intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy.
RUNX3 in Stem Cell and Cancer Biology.
Title: RUNX3 in Stem Cell and Cancer Biology.
Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8(+) T cells with minimal effect on outcomes in mice following influenza infection.
Title: Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8(+) T cells with minimal effect on outcomes in mice following influenza infection.
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Title: Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (17) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548172

Runx3 (e-PCR), detects polymorphism
- UniSTS:463955

Runx3 (e-PCR), detects polymorphism
- UniSTS:141245

Runx3 (e-PCR), detects polymorphism
- UniSTS:547304

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chondrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of CD4-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of CD8-positive, alpha-beta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to transforming growth factor beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within type II interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
part_of core-binding factor complex	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: runt-related transcription factor 3

Names: CBF-alpha-3; PEA2-alpha C; PEBP2-alpha C; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; acute myeloid leukemia 2 protein; core binding factor alpha 3; core-binding factor subunit alpha-3; oncogene AML-2; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; transcription factor AML2/CBFA3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369050.1 → NP_001355979.1 runt-related transcription factor 3 isoform 2

Status: VALIDATED

Source sequence(s)

AL731718

Consensus CDS

CCDS89843.1

UniProtKB/Swiss-Prot

B2FDG4, Q64131, Q99P92, Q9R199

Related

ENSMUSP00000113159.2, ENSMUST00000119564.2

Conserved Domains (2) summary

pfam00853
Location:63 → 184

Runt; Runt domain

pfam08504
Location:314 → 409

RunxI; Runx inhibition domain
NM_019732.2 → NP_062706.2 runt-related transcription factor 3 isoform 1

See identical proteins and their annotated locations for NP_062706.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK155436, AL731718

Consensus CDS

CCDS18782.1

UniProtKB/TrEMBL

Q3U1Q3

Related

ENSMUSP00000050353.8, ENSMUST00000056977.14

Conserved Domains (2) summary

pfam00853
Location:77 → 198

Runt; Runt domain

pfam08504
Location:328 → 423

RunxI; Runx inhibition domain