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Casr calcium-sensing receptor [ Mus musculus (house mouse) ]

Gene ID: 12374, updated on 11-Apr-2024

Summary

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Official Symbol
Casrprovided by MGI
Official Full Name
calcium-sensing receptorprovided by MGI
Primary source
MGI:MGI:1351351
See related
Ensembl:ENSMUSG00000051980 AllianceGenome:MGI:1351351
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaR; Gprc2a
Summary
Predicted to enable several functions, including integrin binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Acts upstream of or within positive regulation of ATPase activity; positive regulation of gene expression; and regulation of calcium ion transport. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial pouch; central nervous system; lung; metanephros; and superior cervical ganglion. Used to study autosomal dominant hypocalcemia 1; familial hypocalciuric hypercalcemia 1; and hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant hypocalcemia (multiple); hypercalcemia (multiple); hyperparathyroidism (multiple); idiopathic generalized epilepsy 8; and nephrolithiasis (multiple). Orthologous to human CASR (calcium sensing receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 6.6) and mammary gland adult (RPKM 0.5) See more
Orthologs
human all
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Genomic context

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Location:
16 B3; 16 25.57 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36310947..36382605, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36490585..36562141, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25903 Neighboring gene stefin A3 Neighboring gene STARR-seq mESC enhancer starr_40764 Neighboring gene STARR-seq mESC enhancer starr_40765 Neighboring gene STARR-seq mESC enhancer starr_40766 Neighboring gene CD86 antigen Neighboring gene predicted gene, 49663 Neighboring gene STARR-seq mESC enhancer starr_40769 Neighboring gene predicted gene, 41451

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Differential parathyroid and kidney Ca(2+)-sensing receptor activation in autosomal dominant hypocalcemia 1. van Megen WH, et al. EBioMedicine, 2022 Apr. PMID 35313217, Free PMC Article
  2. Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Sundararaman SS, et al. Sci Rep, 2021 May 17. PMID 34001955, Free PMC Article
  3. Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice. Mayer CA, et al. Pediatr Res, 2022 May. PMID 33958714, Free PMC Article
  4. Efficient detection of eukaryotic calcium-sensing receptor (CaSR) by polyclonal antibody against prokaryotic expressed truncated CaSR. Ramezani A, et al. Mol Biol Rep, 2020 Oct. PMID 33001312
  5. Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice. Wang C, et al. Biochem Biophys Res Commun, 2020 Oct 1. PMID 32768195

See all (166) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus.
    Title: Alterations in gene expression and microbiome composition upon calcium-sensing receptor deletion in the mouse esophagus.
  2. Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice.
    Title: Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice.
  3. CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
    Title: CaSR modulates proliferation of the superficial zone cells in temporomandibular joint cartilage via the PTHrP nuclear localization sequence.
  4. Role of calcium-sensing receptor in regulating activation susceptibility of postovulatory aging mouse oocytes.
    Title: Role of calcium-sensing receptor in regulating activation susceptibility of postovulatory aging mouse oocytes.
  5. Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
    Title: Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways.
  6. The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function.
    Title: The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function.
  7. Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
    Title: Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
  8. Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.
    Title: Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.
  9. Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice.
    Title: Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice.
  10. Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice.
    Title: Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice.
Submit: New GeneRIF Correction See all GeneRIFs (108)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in bile acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in ossification ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of ATP-dependent activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of ATP-dependent activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynaptic membrane potential EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of presynaptic membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of presynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
extracellular calcium-sensing receptor
Names
G protein-coupled receptor, family C, group 2, member A
PCaR1
cation sensing receptor
parathyroid cell calcium-sensing receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013803.3 → NP_038831.2  extracellular calcium-sensing receptor precursor

    See identical proteins and their annotated locations for NP_038831.2

    Status: VALIDATED

    Source sequence(s)
    AC074229, AF110178
    Consensus CDS
    CCDS28154.1
    UniProtKB/Swiss-Prot
    G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2
    Related
    ENSMUSP00000069080.8, ENSMUST00000063597.14
    Conserved Domains (3) summary
    cd15282
    Location:611 → 862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33 → 530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538 → 591
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36310947..36382605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521730.3 → XP_006521793.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521793.1

    UniProtKB/Swiss-Prot
    G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2
    Conserved Domains (3) summary
    cd15282
    Location:611 → 862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33 → 530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538 → 591
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. XM_036159757.1 → XP_036015650.1  extracellular calcium-sensing receptor isoform X1

    UniProtKB/Swiss-Prot
    G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2
    Conserved Domains (3) summary
    cd15282
    Location:611 → 862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33 → 530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538 → 591
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  3. XM_006521731.5 → XP_006521794.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521794.1

    UniProtKB/Swiss-Prot
    G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2
    Related
    ENSMUSP00000133500.2, ENSMUST00000172826.2
    Conserved Domains (3) summary
    cd15282
    Location:611 → 862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33 → 530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538 → 591
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  4. XM_006521732.3 → XP_006521795.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521795.1

    UniProtKB/Swiss-Prot
    G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2
    Conserved Domains (3) summary
    cd15282
    Location:611 → 862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33 → 530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538 → 591
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  5. XM_006521729.3 → XP_006521792.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521792.1

    UniProtKB/Swiss-Prot
    G3UX06, O08968, O88519, Q9QY95, Q9QY96, Q9QZU8, Q9R1D6, Q9R1Y2
    Conserved Domains (3) summary
    cd15282
    Location:611 → 862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33 → 530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538 → 591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QY96.2 GenPept UniProtKB/Swiss-Prot:Q9QY96

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