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Capn1 calpain 1 [ Mus musculus (house mouse) ]

Gene ID: 12333, updated on 14-Apr-2024

Summary

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Official Symbol
Capn1provided by MGI
Official Full Name
calpain 1provided by MGI
Primary source
MGI:MGI:88263
See related
Ensembl:ENSMUSG00000024942 AllianceGenome:MGI:88263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Capa1; Capa-1; mu-calpin
Summary
Enables calcium-dependent cysteine-type endopeptidase activity. Acts upstream of or within mammary gland involution; proteolysis; and receptor catabolic process. Located in cytosol; lysosome; and mitochondrion. Is expressed in molar; oral region epithelium; and skin. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to human CAPN1 (calpain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 48.9), bladder adult (RPKM 44.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6038573..6065855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5988545..6015825, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), alpha 2 Neighboring gene solute carrier family 22 (organic anion transporter), member 20 Neighboring gene predicted gene, 31719 Neighboring gene predicted gene 10814 Neighboring gene predicted gene, 19505 Neighboring gene STARR-positive B cell enhancer ABC_E7629 Neighboring gene thymosin, beta 10 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension. Deng H, et al. J Cell Mol Med, 2022 May. PMID 35365973, Free PMC Article
  2. Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy. Saadane A, et al. Am J Pathol, 2021 Oct. PMID 34214506, Free PMC Article
  3. Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease. Weber JJ, et al. Hum Mol Genet, 2020 Apr 15. PMID 31960910, Free PMC Article
  4. Increased calpain-1 in mitochondria induces dilated heart failure in mice: role of mitochondrial superoxide anion. Cao T, et al. Basic Res Cardiol, 2019 Mar 15. PMID 30874894, Free PMC Article
  5. Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice. Heysieattalab S, et al. Neurobiol Learn Mem, 2020 Apr. PMID 30735788

See all (188) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
    Title: Hydrogen-rich saline alleviates cardiomyocyte apoptosis by reducing expression of calpain1 via miR-124-3p.
  2. Calpain-1 mediates vascular remodelling and fibrosis via HIF-1alpha in hypoxia-induced pulmonary hypertension.
    Title: Calpain-1 mediates vascular remodelling and fibrosis via HIF-1α in hypoxia-induced pulmonary hypertension.
  3. Exosome-mediated improvement in membrane integrity and muscle function in dystrophic mice.
    Title: Exosome-mediated improvement in membrane integrity and muscle function in dystrophic mice.
  4. miR1405p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.
    Title: miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.
  5. Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes.
    Title: Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes.
  6. Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy.
    Title: Photoreceptor Cell Calcium Dysregulation and Calpain Activation Promote Pathogenic Photoreceptor Oxidative Stress and Inflammation in Prodromal Diabetic Retinopathy.
  7. Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
    Title: Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy.
  8. Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
    Title: Calpain-1 ablation partially rescues disease-associated hallmarks in models of Machado-Joseph disease.
  9. Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice.
    Title: Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice.
  10. Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro.
    Title: Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro.
Submit: New GeneRIF Correction See all GeneRIFs (129)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mammary gland involution IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within receptor catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to angiotensin ISO
Inferred from Sequence Orthology
more info
  
involved_in self proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
calpain-1 catalytic subunit
Names
CANP 1
calcium-activated neutral proteinase 1
calpain mu-type
calpain-1 large subunit
micromolar-calpain
mu-calpain
muCANP
NP_001103974.1
NP_031626.1
XP_036017307.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110504.2 → NP_001103974.1  calpain-1 catalytic subunit

    See identical proteins and their annotated locations for NP_001103974.1

    Status: VALIDATED

    Source sequence(s)
    AC131692
    Consensus CDS
    CCDS37893.1
    UniProtKB/Swiss-Prot
    O35350, O88666
    UniProtKB/TrEMBL
    Q3TI07, Q3UDG8, Q80Y25, Q8C2J1
    Related
    ENSMUSP00000127498.2, ENSMUST00000164843.10
    Conserved Domains (6) summary
    PTZ00184
    Location:537 → 680
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:589 → 643
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:366 → 518
    Calpain_III; Calpain large subunit, domain III
    pfam13833
    Location:556 → 609
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:622 → 704
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. NM_007600.4 → NP_031626.1  calpain-1 catalytic subunit

    See identical proteins and their annotated locations for NP_031626.1

    Status: VALIDATED

    Source sequence(s)
    AC131692
    Consensus CDS
    CCDS37893.1
    UniProtKB/Swiss-Prot
    O35350, O88666
    UniProtKB/TrEMBL
    Q3TI07, Q3UDG8, Q80Y25, Q8C2J1
    Related
    ENSMUSP00000025891.9, ENSMUST00000025891.11
    Conserved Domains (6) summary
    PTZ00184
    Location:537 → 680
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:589 → 643
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:366 → 518
    Calpain_III; Calpain large subunit, domain III
    pfam13833
    Location:556 → 609
    EF-hand_8; EF-hand domain pair
    cl08302
    Location:622 → 704
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6038573..6065855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161414.1 → XP_036017307.1  calpain-1 catalytic subunit isoform X1

    UniProtKB/TrEMBL
    Q3TB79
    Conserved Domains (4) summary
    cd00214
    Location:366 → 523
    Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    cd15897
    Location:545 → 573
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:545 → 647
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00648
    Location:56 → 352
    Peptidase_C2; Calpain family cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35350.1 GenPept UniProtKB/Swiss-Prot:O35350

Gene LinkOut

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