Camk2a calcium/calmodulin-dependent protein kinase II alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camk2aprovided by MGI
Official Full Name: calcium/calmodulin-dependent protein kinase II alphaprovided by MGI
Primary source: MGI:MGI:88256
See related: Ensembl:ENSMUSG00000024617 AllianceGenome:MGI:88256
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CaMKII; mKIAA0968
Summary: Enables calmodulin binding activity; glutamate receptor binding activity; and protein serine/threonine kinase activity. Involved in several processes, including protein phosphorylation; regulation of endocannabinoid signaling pathway; and regulation of synaptic vesicle docking. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; positive regulation of cardiac muscle cell apoptotic process; and response to ischemia. Located in Schaffer collateral - CA1 synapse; mitochondrion; and postsynaptic density. Is expressed in several structures, including alimentary system; early embryo; eye; genitourinary system; and nervous system. Used to study autism spectrum disorder and bipolar disorder. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 53 and autosomal recessive non-syndromic intellectual disability. Orthologous to human CAMK2A (calcium/calmodulin dependent protein kinase II alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 365.9) and frontal lobe adult (RPKM 310.4) See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61058704..61121224)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (60925307..60988152)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation.
Title: Binding of CaMKII to the NMDA receptor is sufficient for long-term potentiation.
A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.
Title: A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons.
Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.
Title: Decreased nitrosylation of CaMKII causes aging-associated impairments in memory and synaptic plasticity in mice.
Autophosphorylation of alphaCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol-induced loss of excitatory synapses.
Title: Autophosphorylation of αCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol-induced loss of excitatory synapses.
Calcium/calmodulin-dependent protein kinase IIalpha heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.
Title: Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment.
CaMKIIalpha knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest.
Title: CaMKIIα knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest.
The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.
Title: The oxidation-resistant CaMKII-MM281/282VV mutation does not prevent arrhythmias in CPVT1.
Synaptic memory requires CaMKII.
Title: Synaptic memory requires CaMKII.
Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts.
Title: Activation of transient receptor potential vanilloid 4 exacerbates myocardial ischemia-reperfusion injury via JNK-CaMKII phosphorylation pathway in isolated mice hearts.
ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.
Title: ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion.

Submit: New GeneRIF Correction See all GeneRIFs (249)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (11) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Camk2a (e-PCR), detects polymorphism
- UniSTS:141219

RH125135 (e-PCR)
- UniSTS:161957

UniSTS:225275 (e-PCR)
- UniSTS:225275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NMDA selective glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calmodulin dependent kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine development	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocannabinoid signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle docking	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle docking	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
part_of calcium- and calmodulin-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in glutamatergic postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type II subunit alpha

Names: CaMK II; alpha-CaMKII; caM kinase II subunit alpha; caMK-II subunit alpha

NP_001273738.1

EC 2.7.11.17

NP_001390238.1

EC 2.7.11.17

NP_001390241.1

EC 2.7.11.17

NP_033922.1

EC 2.7.11.17

NP_803126.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286809.1 → NP_001273738.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a significant portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 2. The resulting isoform (3) is shorter and has a distinct N-terminus, compared to isoform 2.

Source sequence(s)

AK083245, AW490258, BB659027, BC031745, BY713276

Consensus CDS

CCDS70898.1

UniProtKB/TrEMBL

F8WHB5

Related

ENSMUSP00000048325.7, ENSMUST00000039904.7

Conserved Domains (1) summary

pfam08332
Location:57 → 184

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_001403309.1 → NP_001390238.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 4

Status: VALIDATED

Source sequence(s)

AC124431

UniProtKB/TrEMBL

F8WIS9

Related

ENSMUSP00000025519.5, ENSMUST00000025519.11
NM_001403312.1 → NP_001390241.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

Status: VALIDATED

Source sequence(s)

AC124431
NM_009792.3 → NP_033922.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1

See identical proteins and their annotated locations for NP_033922.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, lacks a significant portion of the 5' coding region, initiates translation at an alternate start codon, and has an additional internal exon in the coding region, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus and an additional internal segment, compared to isoform 2.

Source sequence(s)

AC124431

Consensus CDS

CCDS29277.1

UniProtKB/Swiss-Prot

P11798

Related

ENSMUSP00000110950.3, ENSMUST00000115295.9

Conserved Domains (1) summary

pfam08332
Location:68 → 195

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
NM_177407.4 → NP_803126.1 calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

See identical proteins and their annotated locations for NP_803126.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) is the longest transcript and encodes the longest isoform (2).

Source sequence(s)

AK083245, AW490258, BC031745

Consensus CDS

CCDS29276.1

UniProtKB/Swiss-Prot

P11798, Q61284, Q6ZWN4

UniProtKB/TrEMBL

Q80TN1

Related

ENSMUSP00000099952.4, ENSMUST00000102888.10

Conserved Domains (2) summary

cd14086
Location:11 → 302

STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

pfam08332
Location:346 → 473

CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain