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Bmpr1b bone morphogenetic protein receptor, type 1B [ Mus musculus (house mouse) ]

Gene ID: 12167, updated on 4-Jan-2025

Summary

Official Symbol
Bmpr1bprovided by MGI
Official Full Name
bone morphogenetic protein receptor, type 1Bprovided by MGI
Primary source
MGI:MGI:107191
See related
Ensembl:ENSMUSG00000052430 AllianceGenome:MGI:107191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Alk6; SKR6; ALK-6; Acvrlk6; BMPR-1B; BMPR-IB; CFK-43a
Summary
This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type I receptor, and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important in skeletal and bone development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Expression
Biased expression in limb E14.5 (RPKM 1.8), frontal lobe adult (RPKM 1.8) and 11 other tissues See more
Orthologs
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Genomic context

See Bmpr1b in Genome Data Viewer
Location:
3 H1; 3 66.11 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (141540230..141875335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (141837135..142169585, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 alpha 2 Neighboring gene STARR-seq mESC enhancer starr_09144 Neighboring gene STARR-seq mESC enhancer starr_09145 Neighboring gene unc-5 netrin receptor C Neighboring gene predicted gene 15689 Neighboring gene STARR-seq mESC enhancer starr_09146 Neighboring gene STARR-seq mESC enhancer starr_09149 Neighboring gene STARR-seq mESC enhancer starr_09150 Neighboring gene STARR-seq mESC enhancer starr_09151 Neighboring gene STARR-positive B cell enhancer mm9_chr3:141938065-141938366 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:141945756-141946056 Neighboring gene STARR-positive B cell enhancer ABC_E11225 Neighboring gene PDZ and LIM domain 5 Neighboring gene STARR-seq mESC enhancer starr_09153 Neighboring gene STARR-positive B cell enhancer ABC_E4601 Neighboring gene STARR-seq mESC enhancer starr_09155

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables ATP binding  
enables BMP binding PubMed 
enables BMP binding  
enables BMP receptor activity PubMed 
enables BMP receptor activity  
enables SMAD binding  
enables SMAD binding  
enables activin receptor activity, type I  
enables activin receptor activity, type II  
enables metal ion binding  
enables protein binding PubMed 
enables protein serine/threonine kinase activity  
enables transforming growth factor beta receptor activity PubMed 
enables transforming growth factor beta receptor activity, type I  
enables transforming growth factor beta receptor activity, type I PubMed 
enables transforming growth factor beta receptor activity, type II  
enables transforming growth factor beta receptor activity, type III  
enables transmembrane receptor protein serine/threonine kinase activity PubMed 
enables transmembrane signaling receptor activity  
Items 1 - 25 of 45
Process Evidence Code Pubs
involved_in BMP signaling pathway  
involved_in BMP signaling pathway PubMed 
acts_upstream_of_or_within BMP signaling pathway PubMed 
acts_upstream_of_or_within BMP signaling pathway PubMed 
involved_in BMP signaling pathway  
involved_in activin receptor signaling pathway  
involved_in bone development PubMed 
acts_upstream_of_or_within camera-type eye development PubMed 
acts_upstream_of_or_within cartilage condensation PubMed 
involved_in cell differentiation  
acts_upstream_of_or_within cell differentiation PubMed 
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway PubMed 
involved_in cellular response to BMP stimulus  
involved_in cellular response to growth factor stimulus  
involved_in cellular response to growth factor stimulus PubMed 
acts_upstream_of_or_within central nervous system neuron differentiation PubMed 
involved_in chondrocyte development  
acts_upstream_of_or_within chondrocyte differentiation PubMed 
involved_in chondrocyte differentiation PubMed 
involved_in dorsal/ventral pattern formation  
acts_upstream_of_or_within dorsal/ventral pattern formation PubMed 
involved_in endochondral bone morphogenesis  
involved_in estrogen biosynthetic process PubMed 
acts_upstream_of_or_within eye development PubMed 
involved_in inflammatory response PubMed 
involved_in negative regulation of chondrocyte proliferation  
involved_in osteoblast differentiation PubMed 
involved_in osteoblast differentiation  
involved_in ovarian cumulus expansion PubMed 
involved_in ovulation cycle PubMed 
involved_in positive regulation of bone mineralization  
involved_in positive regulation of bone mineralization  
involved_in positive regulation of cartilage development  
involved_in positive regulation of chondrocyte differentiation  
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway via death domain receptors PubMed 
involved_in positive regulation of gene expression  
acts_upstream_of positive regulation of gene expression  
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in proteoglycan biosynthetic process  
acts_upstream_of_or_within retina development in camera-type eye PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway PubMed 
Items 1 - 25 of 45
Component Evidence Code Pubs
located_in dendrite  
located_in dendrite  
located_in neuronal cell body  
located_in neuronal cell body  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 
part_of receptor complex  

General protein information

Preferred Names
bone morphogenetic protein receptor type-1B
Names
BMP type-1B receptor
activin receptor-like kinase 6
serine/threonine-protein kinase receptor R6
NP_001264145.1
NP_001264146.1
NP_001264147.1
NP_001264149.1
NP_001341972.1
NP_031586.1
XP_006501002.1
XP_006501003.1
XP_006501005.1
XP_006501006.1
XP_030108258.1
XP_036018761.1
XP_036018762.1
XP_036018763.1
XP_036018764.1
XP_036018765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277216.3NP_001264145.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264145.1

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492, AC161533
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000096167.2, ENSMUST00000098568.8
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  2. NM_001277217.3NP_001264146.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264146.1

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000101837.2, ENSMUST00000106230.2
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  3. NM_001277218.2NP_001264147.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_001264147.1

    Status: VALIDATED

    Source sequence(s)
    AC157492
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000101839.2, ENSMUST00000106232.8
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  4. NM_001277220.2NP_001264149.1  bone morphogenetic protein receptor type-1B isoform b

    See identical proteins and their annotated locations for NP_001264149.1

    Status: VALIDATED

    Source sequence(s)
    AC157492
    UniProtKB/TrEMBL
    Q3USS1
    Conserved Domains (3) summary
    smart00220
    Location:194478
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14219
    Location:187491
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:3199
    Activin_recp; Activin types I and II receptor domain
  5. NM_001355043.2NP_001341972.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC157492
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  6. NM_001428393.1NP_001415322.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492, AC161533
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
  7. NM_001428394.1NP_001415323.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
  8. NM_001428395.1NP_001415324.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492, AC161533
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
  9. NM_001428396.1NP_001415325.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
  10. NM_001428397.1NP_001415326.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC139128, AC157492, AC161533
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
  11. NM_001428398.1NP_001415327.1  bone morphogenetic protein receptor type-1B isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC157492
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
  12. NM_007560.5NP_031586.1  bone morphogenetic protein receptor type-1B isoform a precursor

    See identical proteins and their annotated locations for NP_031586.1

    Status: VALIDATED

    Source sequence(s)
    AC157492
    Consensus CDS
    CCDS17874.1
    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Related
    ENSMUSP00000029948.8, ENSMUST00000029948.15
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    141540230..141875335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162871.1XP_036018764.1  bone morphogenetic protein receptor type-1B isoform X1

    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  2. XM_036162870.1XP_036018763.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  3. XM_006500940.5XP_006501003.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  4. XM_006500942.3XP_006501005.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  5. XM_006500939.5XP_006501002.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  6. XM_036162869.1XP_036018762.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  7. XM_030252398.2XP_030108258.1  bone morphogenetic protein receptor type-1B isoform X1

    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  8. XM_036162868.1XP_036018761.1  bone morphogenetic protein receptor type-1B isoform X1

    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  9. XM_006500943.5XP_006501006.1  bone morphogenetic protein receptor type-1B isoform X1

    See identical proteins and their annotated locations for XP_006501006.1

    UniProtKB/Swiss-Prot
    P36898, Q3TRF2
    UniProtKB/TrEMBL
    B2RRZ4
    Conserved Domains (2) summary
    cd14219
    Location:198502
    STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
    pfam01064
    Location:34106
    Activin_recp; Activin types I and II receptor domain
  10. XM_036162872.1XP_036018765.1  bone morphogenetic protein receptor type-1B isoform X2

    Conserved Domains (1) summary
    cd14144
    Location:3289
    STKc_BMPR1; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor
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