Blk B lymphoid kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Blkprovided by MGI
Official Full Name: B lymphoid kinaseprovided by MGI
Primary source: MGI:MGI:88169
See related: Ensembl:ENSMUSG00000014453 AllianceGenome:MGI:88169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of leukocyte apoptotic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including 2-cell stage embryo; central nervous system; ileum; male reproductive gland or organ; and peripheral nervous system. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human BLK (BLK proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 50.7), mammary gland adult (RPKM 6.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.25 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (63610286..63654636, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (63372837..63417187, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
Title: BLK positively regulates TLR/IL-1R signaling by catalyzing TOLLIP phosphorylation.
our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
Title: Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels.
BLK risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
Title: Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.
this study has revealed a previously unappreciated role for Blk in the development and activation of MZ B cells
Title: Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.
BCR-ABL downregulates the Blk gene (encoding B-lymphoid kinase) through c-Myc in leukemic stem cells in chronic myeloid leukemia
Title: The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells.
Data suggest a role of tyrosine kinase Btk in the regulation of immune cell unctions and innate inflammatory response.
Title: Tyrosine kinase Btk is required for NK cell activation.
Analysis of Blk-deficient mice reveals that Blk is required for the development of IL-17-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.
Title: Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing γδ T cells.
Blk, being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.
Title: Bfk, a novel member of the bcl2 gene family, is highly expressed in principal cells of the mouse epididymis and demonstrates a predominant nuclear localization.
sustained activation of Blk induces responses normally associated with the pre-BCR.
Title: Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase Blk

Names: b lymphocyte kinase; p55-Blk

NP_031575.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007549.2 → NP_031575.2 tyrosine-protein kinase Blk

See identical proteins and their annotated locations for NP_031575.2

Status: VALIDATED

Source sequence(s)

AK089888

Consensus CDS

CCDS27200.1

UniProtKB/Swiss-Prot

P16277, Q8K2M8

UniProtKB/TrEMBL

Q3TAT8

Related

ENSMUSP00000014597.4, ENSMUST00000014597.5

Conserved Domains (4) summary

cd10371
Location:114 → 213

SH2_Src_Blk; Src homology 2 (SH2) domain found in B lymphoid kinase (Blk)

pfam07714
Location:235 → 484

Pkinase_Tyr; Protein tyrosine kinase

cl17036
Location:56 → 109

SH3; Src Homology 3 domain superfamily

cl21453
Location:227 → 490

PKc_like; Protein Kinases, catalytic domain