Apoc2 apolipoprotein C2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Apoc2provided by MGI
Official Full Name: apolipoprotein C2provided by MGI
Primary source: MGI:MGI:88054
See related: Ensembl:ENSMUSG00000002992 AllianceGenome:MGI:88054
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: apo-CII; apoC-II
Summary: Predicted to enable several functions, including identical protein binding activity; lipase activator activity; and phospholipase binding activity. Predicted to be involved in several processes, including lipid transport; positive regulation of lipase activity; and regulation of lipid metabolic process. Predicted to be located in extracellular space. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in several structures, including capillary; central nervous system; liver; lung; and yolk sac endoderm. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 546.8), small intestine adult (RPKM 366.6) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19405504..19411866, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19671579..19677941, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel mouse model of apoC-II deficiency was created with an apoC-II peptide that reverses the hypertriglyceridemia.
Title: Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide.
Data show that apoC-II and LPL mRNAs correlate temporally and geographically with surfactant lipid synthesis in preparation for birth and suggest that fatty acid recruitment from the circulation by apoC-II-activated LPL is modulated by apoC-II secretion.
Title: Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth.
These results are compatible with a role for apolipoproteins in lipid metabolism and transport in the developing lung in association with the sex difference in surfactant lipid synthesis.
Title: Apolipoprotein A-I, A-II, C-II, and H expression in the developing lung and sex difference in surfactant lipids.
regulated expression of gene cluster in macrophages
Title: Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.
TR4 can also regulate apolipoprotein E, C-I, and C-II gene expression via the TR4 response element within the hepatic control region
Title: Disruption of TR4 orphan nuclear receptor reduces the expression of liver apolipoprotein E/C-I/C-II gene cluster.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Apoc2 (e-PCR), detects polymorphism
- UniSTS:516126

Apoc2 (e-PCR), detects polymorphism
- UniSTS:532535

Z15090 (e-PCR)
- UniSTS:179532

GDB:179875 (e-PCR)
- UniSTS:155055

Apoc2 (e-PCR), detects polymorphism
- UniSTS:265211

Apoc2 (e-PCR), detects polymorphism
- UniSTS:265212

Apoc2 (e-PCR), detects polymorphism
- UniSTS:265213

Readthrough Apoc2l

Readthrough gene: Apoc2l, Included gene: Apoc4

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activator activity	ISO Inferred from Sequence Orthology more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables phospholipase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in chylomicron remnant clearance	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cholesterol transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of very-low-density lipoprotein particle clearance	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chylomicron	IBA Inferred from Biological aspect of Ancestor more info
part_of chylomicron	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of spherical high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: apolipoprotein C-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277944.1 → NP_001264873.1 apolipoprotein C-II precursor

See identical proteins and their annotated locations for NP_001264873.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC149282, BG085960

Consensus CDS

CCDS39801.1

UniProtKB/Swiss-Prot

Q05020

UniProtKB/TrEMBL

D3YXE8, Q3UJG0

Related

ENSMUSP00000115173.2, ENSMUST00000142352.9

Conserved Domains (1) summary

pfam05355
Location:21 → 96

Apo-CII; Apolipoprotein C-II
NM_001309795.1 → NP_001296724.1 apolipoprotein C-II precursor

See identical proteins and their annotated locations for NP_001296724.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AA059961, AC149282, AK146468

Consensus CDS

CCDS39801.1

UniProtKB/Swiss-Prot

Q05020

UniProtKB/TrEMBL

D3YXE8, Q3UJG0

Related

ENSMUSP00000118291.2, ENSMUST00000134116.8

Conserved Domains (1) summary

pfam05355
Location:21 → 96

Apo-CII; Apolipoprotein C-II