Gpr37 G protein-coupled receptor 37 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr37provided by RGD
Official Full Name: G protein-coupled receptor 37provided by RGD
Primary source: RGD:619848
See related: Ensembl:ENSRNOG00000002524 AllianceGenome:RGD:619848
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ednrbl
Summary: Predicted to enable several functions, including G protein-coupled receptor activity; Hsp70 protein binding activity; and PDZ domain binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; dendrite development; and negative regulation of hydrogen peroxide-induced cell death. Predicted to act upstream of or within dopamine biosynthetic process; locomotion involved in locomotory behavior; and positive regulation of dopamine metabolic process. Predicted to be located in cell surface and endoplasmic reticulum. Predicted to be part of receptor complex and ubiquitin ligase complex. Predicted to be active in plasma membrane and synapse. Orthologous to human GPR37 (G protein-coupled receptor 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 169.0), Kidney (RPKM 24.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (55104355..55126420, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (54138860..54160927, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (51822163..51844228, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.
Title: Prosaposin and its receptors GRP37 and GPR37L1 show increased immunoreactivity in the facial nucleus following facial nerve transection.
Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats.
Title: Age- and sex-associated changes in prosaposin and its receptors in the lacrimal glands of rats.
The present findings indicate that PSAP and its receptors, GPR37 and GPR37L1, are expressed in the major salivary glands of rats and their immunoreactivities differ considerably with age and sex.
Title: Prosaposin and its receptors are differentially expressed in the salivary glands of male and female rats.
PICK1 interacts with parkin and our data showed that PICK1 reduces PAELR expression levels in transiently transfected heterologous cells
Title: The protein interacting with C-kinase (PICK1) interacts with and attenuates parkin-associated endothelial-like (PAEL) receptor-mediated cell death.
expression of Pael-R genes in the nigro-striatal pathway may have significant implication for pathophysiology and treatment of parkinson disease.
Title: Effect of the neurotoxic dose of methamphetamine on gene expression of parkin and Pael-receptors in rat striatum.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140423 (e-PCR)
- UniSTS:222498

UniSTS:495954 (e-PCR)
- UniSTS:495954

Gpr37 (e-PCR), detects polymorphism
- UniSTS:495954

BF409419 (e-PCR)
- UniSTS:248979

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables heat shock protein binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables prosaposin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prosaposin receptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dopamine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dopamine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prosaposin receptor GPR37

Names: G protein-coupled receptor 37 (endothelin receptor type B-like); G-protein coupled receptor CNS1; probable G-protein coupled receptor 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.