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Anxa8 annexin A8 [ Mus musculus (house mouse) ]

Gene ID: 11752, updated on 11-Apr-2024

Summary

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Official Symbol
Anxa8provided by MGI
Official Full Name
annexin A8provided by MGI
Primary source
MGI:MGI:1201374
See related
Ensembl:ENSMUSG00000021950 AllianceGenome:MGI:1201374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anx8
Summary
Predicted to enable several functions, including actin filament binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in endosomal transport; endosome organization; and negative regulation of hydrolase activity. Predicted to act upstream of or within blood coagulation. Predicted to be located in cytosol; late endosome membrane; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including foregut; forelimb; genitourinary system; sensory organ; and skin. Orthologous to several human genes including ANXA8L1 (annexin A8 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.6), placenta adult (RPKM 6.3) and 10 other tissues See more
Orthologs
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Genomic context

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Location:
14 B; 14 20.8 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33807936..33822528)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34085979..34100571)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30083 Neighboring gene STARR-seq mESC enhancer starr_36360 Neighboring gene predicted gene 5460 Neighboring gene RIKEN cDNA A630023A22 gene Neighboring gene anthrax toxin receptor-like Neighboring gene STARR-seq mESC enhancer starr_36361 Neighboring gene predicted gene, 24998 Neighboring gene predicted gene, 30556

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium. Iglesias JM, et al. PLoS One, 2015. PMID 25803307, Free PMC Article
  2. Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Heitzig N, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Apr. PMID 29306076
  3. Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. Poeter M, et al. Nat Commun, 2014 Apr 28. PMID 24769558
  4. Bone matrix regulates osteoclast differentiation and annexin A8 gene expression. Crotti TN, et al. J Cell Physiol, 2011 Dec. PMID 21344395
  5. Specific expression of annexin A8 in adult murine stratified epithelia. Runkel F, et al. J Mol Histol, 2006 Nov. PMID 17082908

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
    Title: Annexin A8 identifies a subpopulation of transiently quiescent c-kit positive luminal progenitor cells of the ductal mammary epithelium.
  2. Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring.
    Title: Bone matrix regulates osteoclast differentiation and annexin A8 gene expression.
  3. Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer
    Title: Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer.
  4. ANXA8 protein is most abundant in stratified epithelia of the postnatal mouse. Its location in the suprabasal layers suggests that ANXA8 may be associated with the terminal differentiation of epithelial cells in these tissues.
    Title: Specific expression of annexin A8 in adult murine stratified epithelia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC40628

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
annexin A8
Names
annexin 8
annexin VIII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281845.1 → NP_001268774.1  annexin A8 isoform 2

    See identical proteins and their annotated locations for NP_001268774.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC164099, AJ002390, AK009085, AK075870
    Consensus CDS
    CCDS70565.1
    UniProtKB/TrEMBL
    Q921D0
    Related
    ENSMUSP00000113662.2, ENSMUST00000120077.2
    Conserved Domains (1) summary
    pfam00191
    Location:26 → 90
    Annexin; Annexin

  2. NM_013473.4 → NP_038501.2  annexin A8 isoform 1

    See identical proteins and their annotated locations for NP_038501.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC164099, AJ002390, AK009085, AK075870
    Consensus CDS
    CCDS26932.1
    UniProtKB/Swiss-Prot
    O35640, Q8K2N9
    Related
    ENSMUSP00000022519.9, ENSMUST00000022519.15
    Conserved Domains (1) summary
    pfam00191
    Location:26 → 90
    Annexin; Annexin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33807936..33822528
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35640.2 GenPept UniProtKB/Swiss-Prot:O35640

Gene LinkOut

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