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C7 complement C7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117517, updated on 5-Mar-2024

Summary

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Symbol
C7provided by RGD
Full Name
complement C7provided by RGD
Primary source
RGD:620318
See related
AllianceGenome:RGD:620318
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in cellular sodium ion homeostasis. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Used to study visual epilepsy. Biomarker of membranous glomerulonephritis and myocardial infarction. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2285.7), Spleen (RPKM 1330.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (55815687..55892605, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (54088116..54165102, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54707621..54781624, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 2B Neighboring gene small nucleolar RNA SNORA17 Neighboring gene caspase recruitment domain family, member 6 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Time course studies on the initiation of complement activation in acute myocardial infarction induced by coronary artery ligation in rats. Sumitra M, et al. Mol Cell Biochem, 2005 Jan. PMID 15724448
  2. C5b-9 terminal complement complex protects oligodendrocytes from death by regulating Bad through phosphatidylinositol 3-kinase/Akt pathway. Soane L, et al. J Immunol, 2001 Aug 15. PMID 11490019
  3. Sublytic complement attack increases intracellular sodium in rat skeletal muscle. Okamoto K, et al. J Surg Res, 2000 May 15. PMID 10792960
  4. Detection of terminal complement components in experimental immune glomerular injury. Adler S, et al. Kidney Int, 1984 Dec. PMID 6241952
  5. Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration. Xiong ZQ, et al. J Neurosci, 2003 Feb 1. PMID 12574424, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
    Title: Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
  2. The membrane attack complex of complement induces caspase activation and apoptosis.
    Title: The membrane attack complex of complement induces caspase activation and apoptosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in intracellular sodium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement component C7
Names
complement component 7
complement component C7-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    55815687..55892605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282844.1 → XP_063138914.1  complement component C7 isoform X1

  2. XM_063282845.1 → XP_063138915.1  complement component C7 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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