P2ry6 pyrimidinergic receptor P2Y6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: P2ry6provided by RGD
Official Full Name: pyrimidinergic receptor P2Y6provided by RGD
Primary source: RGD:620269
See related: Ensembl:ENSRNOG00000019270 AllianceGenome:RGD:620269
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: P2y6
Summary: Predicted to enable G protein-coupled ADP receptor activity; G protein-coupled UDP receptor activity; and G protein-coupled UTP receptor activity. Involved in several processes, including cellular response to pyrimidine ribonucleotide; positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; and positive regulation of smooth muscle cell migration. Located in apical plasma membrane and basolateral plasma membrane. Orthologous to human P2RY6 (pyrimidinergic receptor P2Y6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 12.8), Heart (RPKM 6.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (164707188..164742689, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (155295110..155330610, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (165972439..166008348, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress.
Title: Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress.
The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats.
Title: The role of P2Y6 receptors in the maintenance of neuropathic pain and its improvement of oxidative stress in rats.
In conclusion, the changes in the expression of lncRNAs, mRNAs and proteins (Adamts7, P2ry6, Dlx3 and TP53) may possibly affect endometrial receptivity in rats with endometriosis during the implantation window, probably resulting in implantation failure of the embryo.
Title: lncRNA/mRNA profiling of endometriosis rat uterine tissues during the implantation window.
Results suggest that peripheral activation of P2Y1, P2Y6 and P2Y11 receptors plays a pronociceptive role in formalin-induced pain.
Title: Participation of peripheral P2Y1, P2Y6 and P2Y11 receptors in formalin-induced inflammatory pain in rats.
This study suggested that spinal P2Y6 is present in spinal microglia while P2Y11 receptors are present in both spinal microglia and astrocytes, and both receptors are up-regulated in rats subjected to spinal nerve injury.
Title: Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells.
Wound-induced UDP evokes intestinal epithelial restitution by activation of P2Y6 receptors, which mediates de novo synthesis of TGF-beta.
Title: UDP induces intestinal epithelial migration via the P2Y6 receptor.
Activation of P2Y6 receptors causes bladder overactivity in the anesthetized rat indirectly by releasing ATP.
Title: ATP released via pannexin-1 hemichannels mediates bladder overactivity triggered by urothelial P2Y6 receptors.
We speculate that P2Y(6) may be involved in retinal information processing in different ways
Title: Cellular localization of P2Y₆ receptor in rat retina.
In immunogold electron microscopy, labeling for P2Y1, P2Y6, and P2Y12 receptors were predominantly localized in the basal part of endothelial cells.
Title: P2Y1, P2Y6, and P2Y12 receptors in rat splenic sinus endothelial cells: an immunohistochemical and ultrastructural study.
Here we show that Plasmodium berghei ANKA infection of young rats leads to the modulation of expression of the G-protein-coupled receptor P2Y6. Susceptibility to malaria infection seems to be mediated by the alteration of genes expressing P2Y6R.
Title: Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled ADP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled ADP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled UDP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UDP receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled UTP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled UTP receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to organic cyclic compound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to prostaglandin E stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to purine-containing compound	ISO Inferred from Sequence Orthology more info
involved_in cellular response to pyrimidine ribonucleotide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to pyrimidine ribonucleotide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to pyrimidine ribonucleotide	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol trisphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transepithelial chloride transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: P2Y purinoceptor 6

Names: P2Y ATP receptor 6; pyrimidinergic receptor P2Y, G-protein coupled, 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057124.2 → NP_476465.1 P2Y purinoceptor 6

See identical proteins and their annotated locations for NP_476465.1

Status: PROVISIONAL

Source sequence(s)

BC072520

UniProtKB/Swiss-Prot

Q63371

UniProtKB/TrEMBL

A6I6S4

Related

ENSRNOP00000049439.2, ENSRNOT00000050227.3

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

164707188..164742689 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006229713.5 → XP_006229775.1 P2Y purinoceptor 6 isoform X1

See identical proteins and their annotated locations for XP_006229775.1

UniProtKB/Swiss-Prot

Q63371

UniProtKB/TrEMBL

A6I6S4

Related

ENSRNOP00000087971.1

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_039078872.2 → XP_038934800.1 P2Y purinoceptor 6 isoform X1

UniProtKB/Swiss-Prot

Q63371

UniProtKB/TrEMBL

A6I6S4

Related

ENSRNOP00000094637.1

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006229712.4 → XP_006229774.1 P2Y purinoceptor 6 isoform X1

See identical proteins and their annotated locations for XP_006229774.1

UniProtKB/Swiss-Prot

Q63371

UniProtKB/TrEMBL

A6I6S4

Related

ENSRNOP00000081429.1

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006229715.4 → XP_006229777.1 P2Y purinoceptor 6 isoform X1

See identical proteins and their annotated locations for XP_006229777.1

UniProtKB/Swiss-Prot

Q63371

UniProtKB/TrEMBL

A6I6S4

Conserved Domains (2) summary

cd14964
Location:27 → 54

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:27 → 312

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063268010.1 → XP_063124080.1 P2Y purinoceptor 6 isoform X1

UniProtKB/Swiss-Prot

Q63371

UniProtKB/TrEMBL

A6I6S4