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Gpr176 G protein-coupled receptor 176 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117257, updated on 13-Apr-2024

Summary

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Official Symbol
Gpr176provided by RGD
Official Full Name
G protein-coupled receptor 176provided by RGD
Primary source
RGD:621718
See related
Ensembl:ENSRNOG00000005971 AllianceGenome:RGD:621718
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gpr; Gm1012; RBU-15
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and circadian behavior. Predicted to act upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human GPR176 (G protein-coupled receptor 176). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 34.0), Uterus (RPKM 32.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q35
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (125690750..125791172, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (105236794..105337664, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (110042853..110140756, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene fibrous sheath interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120101637 Neighboring gene uncharacterized LOC134486139 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of a novel putative G protein-coupled receptor from rat aortic smooth muscle. Downregulation of the mRNA level by the cyclic AMP messenger pathway. Ishizaka N, et al. Biochim Biophys Acta, 1994 Jun 21. PMID 8018717
  2. cDNA cloning of a putative G protein-coupled receptor from brain. Hata S, et al. Biochim Biophys Acta, 1995 Mar 14. PMID 7893747
  3. Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour. Doi M, et al. Nat Commun, 2016 Feb 17. PMID 26882873, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 176
Names
G-protein coupled receptor AGR9
putative G protein coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270986.1 → NP_001257915.1  probable G-protein coupled receptor 176

    See identical proteins and their annotated locations for NP_001257915.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q63231, Q64017
    UniProtKB/TrEMBL
    A6HPA4
    Related
    ENSRNOP00000007882.3, ENSRNOT00000007882.5
    Conserved Domains (1) summary
    pfam00001
    Location:57 → 318
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    125690750..125791172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283010.1 → XP_063139080.1  probable G-protein coupled receptor 176 isoform X2

  2. XM_017591434.3 → XP_017446923.1  probable G-protein coupled receptor 176 isoform X1

  3. XM_039104132.2 → XP_038960060.1  probable G-protein coupled receptor 176 isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:4 → 34
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 218
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_039104129.2 → XP_038960057.1  probable G-protein coupled receptor 176 isoform X4

    Conserved Domains (2) summary
    cd14964
    Location:4 → 34
    7tm_GPCRs; TM helix 3 [structural motif]
    cl28897
    Location:1 → 218
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_063283011.1 → XP_063139081.1  probable G-protein coupled receptor 176 isoform X4

  6. XM_063283013.1 → XP_063139083.1  probable G-protein coupled receptor 176 isoform X4

  7. XM_063283012.1 → XP_063139082.1  probable G-protein coupled receptor 176 isoform X4

  8. XM_039104128.2 → XP_038960056.1  probable G-protein coupled receptor 176 isoform X3

    Conserved Domains (2) summary
    cd14964
    Location:21 → 47
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:1 → 276
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64017.2 GenPept UniProtKB/Swiss-Prot:Q64017

Gene LinkOut

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