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Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 117256, updated on 13-Apr-2024

Summary

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Symbol
Ppp2r2cprovided by RGD
Full Name
protein phosphatase 2, regulatory subunit B, gammaprovided by RGD
Primary source
RGD:620920
See related
Ensembl:ENSRNOG00000058202 AllianceGenome:RGD:620920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pr52
Summary
Predicted to enable protein phosphatase regulator activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol. Orthologous to human PPP2R2C (protein phosphatase 2 regulatory subunit Bgamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 625.0) See more
Orthologs
human mouse all
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Genomic context

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Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (78071274..78156212, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (73846547..73931489, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (78679214..78763175, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481775 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene large ribosomal subunit protein eL33-like Neighboring gene mannosidase, alpha, class 2B, member 2 Neighboring gene Morf4 family associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade. Strack S. J Biol Chem, 2002 Nov 1. PMID 12191994
  2. Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells. Yan L, et al. J Biol Chem, 2003 May 16. PMID 12644453
  3. cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase. Akiyama N, et al. Eur J Biochem, 1995 Jun 1. PMID 7607250
  4. Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension. Xiao G, et al. Cell Commun Signal, 2021 Oct 11. PMID 34635097, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension.
    Title: Zinc-mediated activation of CREB pathway in proliferation of pulmonary artery smooth muscle cells in pulmonary hypertension.
  2. PP2A/Bgamma is a positive regulator of MAP kinase signaling in neurons.
    Title: Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade.
  3. PP2A has a role in glucose-regulated EF-2 phosphorylation and protein translation in rat cells
    Title: Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
NP_001399356.1
NP_476457.1
XP_063128879.1
XP_063128880.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412427.1 → NP_001399356.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6GCS7
    Related
    ENSRNOP00000085341.1, ENSRNOT00000109354.1

  2. NM_057116.2 → NP_476457.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1

    See identical proteins and their annotated locations for NP_476457.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    P97888
    UniProtKB/TrEMBL
    A0A0G2JWY9
    Conserved Domains (2) summary
    COG5170
    Location:21 → 438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:27 → 75
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    78071274..78156212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272810.1 → XP_063128880.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X2

  2. XM_063272809.1 → XP_063128879.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97888.1 GenPept UniProtKB/Swiss-Prot:P97888

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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