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Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 117104, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp2r2aprovided by RGD
Official Full Name
protein phosphatase 2, regulatory subunit B, alphaprovided by RGD
Primary source
RGD:620919
See related
Ensembl:ENSRNOG00000011158 AllianceGenome:RGD:620919
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein phosphatase 2A binding activity and tau protein binding activity. Predicted to be involved in peptidyl-serine dephosphorylation. Predicted to act upstream of or within response to morphine. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and glutamatergic synapse. Orthologous to human PPP2R2A (protein phosphatase 2 regulatory subunit Balpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 321.0), Thymus (RPKM 109.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (45380142..45439428, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (41204659..41263924, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (43673958..43733182, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene PNMA family member 2 Neighboring gene BCL2 interacting protein 3 like Neighboring gene uncharacterized LOC102555410 Neighboring gene uncharacterized LOC134482137 Neighboring gene large ribosomal subunit protein eL6-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit. Horowitz B, et al. J Biol Chem, 2013 May 10. PMID 23530045, Free PMC Article
  2. Effect of PP-2A on neurite outgrowth in neuronal cells. Liu D, et al. In Vitro Cell Dev Biol Anim, 2010 Sep. PMID 20585893
  3. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. Pallas DC, et al. J Virol, 1992 Feb. PMID 1370560, Free PMC Article
  4. Influence of hypertonic-hyperoncotic solution and furosemide on canine hydrostatic pulmonary oedema resorption. Wickerts CJ, et al. J Physiol, 1992 Dec. PMID 1302272, Free PMC Article
  5. β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation. Weeks KL, et al. J Am Heart Assoc, 2017 Mar 25. PMID 28343149, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta-AR stimulation induces HDAC5 nuclear accumulation in cardiomyocytes by a mechanism that is protein kinase A-dependent but requires B55alpha-PP2A-mediated dephosphorylation of Ser259/Ser498.
    Title: β-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55α-PP2A-Mediated Dephosphorylation.
  2. Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition
    Title: The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin-43 dephosphorlyation during epidermal barrier acquisition.
  3. Fibroblast growth factor 1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding with retinoblastoma-like 1 (p107) dephosphorylation.
    Title: Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme.
  4. A functional significance to the alpha1, alpha2 helices of B55alpha, the binding site defined by these helices could contribute to interactions between PP2A and some of its cellular regulators.
    Title: Structure- and modeling-based identification of the adenovirus E4orf4 binding site in the protein phosphatase 2A B55α subunit.
  5. these results indicated that PP-2A may be an important positive regulator in neurite outgrowth.
    Title: Effect of PP-2A on neurite outgrowth in neuronal cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase 2A binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to morphine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to morphine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IEA
Inferred from Electronic Annotation
more info
  
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
NP_446451.1
XP_008768954.1
XP_038948885.1
XP_063129985.1
XP_063129986.1
XP_063129987.1
XP_063129988.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053999.2 → NP_446451.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

    See identical proteins and their annotated locations for NP_446451.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128731
    UniProtKB/Swiss-Prot
    A1A5M9, O35512, P36876, P36878
    UniProtKB/TrEMBL
    A0A8I6AVF8, A6K6P0
    Related
    ENSRNOP00000015318.5, ENSRNOT00000015318.7
    Conserved Domains (2) summary
    COG5170
    Location:7 → 442
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:31 → 79
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    45380142..45439428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273917.1 → XP_063129987.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X3

  2. XM_063273916.1 → XP_063129986.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X2

  3. XM_063273915.1 → XP_063129985.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1

  4. XM_063273918.1 → XP_063129988.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

  5. XM_039092957.1 → XP_038948885.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    UniProtKB/TrEMBL
    A6K6P2
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]

  6. XM_008770732.4 → XP_008768954.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X4

    See identical proteins and their annotated locations for XP_008768954.1

    UniProtKB/TrEMBL
    A6K6P2
    Conserved Domains (2) summary
    COG5170
    Location:2 → 283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:21 → 57
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36876.1 GenPept UniProtKB/Swiss-Prot:P36876

Gene LinkOut

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