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Mmp10 matrix metallopeptidase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117061, updated on 30-Mar-2024

Summary

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Official Symbol
Mmp10provided by RGD
Official Full Name
matrix metallopeptidase 10provided by RGD
Primary source
RGD:620192
See related
Ensembl:ENSRNOG00000032832 AllianceGenome:RGD:620192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SL-2
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within regulation of cell migration. Predicted to be located in extracellular matrix and extracellular region. Orthologous to human MMP10 (matrix metallopeptidase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human mouse all
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Genomic context

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Location:
8q11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (12974707..12982613)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (4689840..4697748)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (5734348..5742243)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 3 Neighboring gene matrix metallopeptidase 1 Neighboring gene matrix metallopeptidase 8 Neighboring gene matrix metallopeptidase 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats. Takamura Y, et al. Mol Vis, 2013. PMID 24339723, Free PMC Article
  2. Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Breathnach R, et al. Nucleic Acids Res, 1987 Feb 11. PMID 3547333, Free PMC Article
  3. Molecular cloning and characterization of v-mos-activated transformation-associated proteins. Chan JC, et al. J Biol Chem, 1992 Jan 15. PMID 1370458
  4. Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Friese RS, et al. Clin Exp Hypertens, 2009 Oct. PMID 19886850, Free PMC Article
  5. Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein. De Vouge MW, et al. Oncogene, 1992 Jan. PMID 1741158

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
    Title: Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
  2. MMP-10 modulates corneal epithelial wound healing.
    Title: Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stromelysin-2
Names
matrix metalloproteinase-10
transformation-associated protein 34A
transin-2
NP_598198.2
XP_038936637.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133514.2 → NP_598198.2  stromelysin-2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    P07152
    UniProtKB/TrEMBL
    A6JN35, G3V788
    Related
    ENSRNOP00000013118.3, ENSRNOT00000013119.5
    Conserved Domains (3) summary
    cd00094
    Location:286 → 476
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 264
    Peptidase_M10; Matrixin
    pfam01471
    Location:33 → 87
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    12974707..12982613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080709.1 → XP_038936637.1  stromelysin-2 isoform X1

    UniProtKB/Swiss-Prot
    P07152
    Conserved Domains (3) summary
    cd00094
    Location:285 → 475
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:108 → 264
    Peptidase_M10; Matrixin
    pfam01471
    Location:33 → 87
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07152.1 GenPept UniProtKB/Swiss-Prot:P07152

Gene LinkOut

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