Ccr3 C-C motif chemokine receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccr3provided by RGD
Official Full Name: C-C motif chemokine receptor 3provided by RGD
Primary source: RGD:620593
See related: Ensembl:ENSRNOG00000006736 AllianceGenome:RGD:620593
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cmkbr3
Summary: Predicted to enable C-C chemokine binding activity and C-C chemokine receptor activity. Involved in ERK1 and ERK2 cascade; angioblast cell migration; and leukocyte chemotaxis. Located in endosome; extracellular space; and plasma membrane. Used to study asthma and myocardial infarction. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in asthma; ovary epithelial cancer; and rhinitis. Orthologous to human CCR3 (C-C motif chemokine receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 240.1) and Uterus (RPKM 12.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (132463533..132511601)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (123586100..123634178)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (133026539..133040999)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain.
Title: Blockade of CC Chemokine Receptor Type 3 Diminishes Pain and Enhances Opioid Analgesic Potency in a Model of Neuropathic Pain.
CCR3 levels in EAE rats were significantly increased. CCR3 levels in brain tissues were positively correlated with the inflammatory scores.
Title: CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis.
our data suggest that the CCL11-CCR3 interaction mainly activates PI3K/Akt signal transduction pathway in HUVECs.
Title: CCL11 promotes angiogenic activity by activating the PI3K/Akt pathway in HUVECs.
CCR3 plays no role in choroidal neovascularization development.
Title: What is the role of CCR3 in choroidal neovascularization?
The expression of Eotaxin in nasal mucosa increased, and the expression of CCR3 in bone marrow increased in the model of allergic rhinitis.
Title: [The expression and significance of eotaxin gene in nasal mucosa and CCR3 in bone marrow in model of allergic rhinitis].
Allergen-induced recruitment of eosinophils in the distal septum and turbinates was maximal at 8h post-challenge, and was correlated with 2-4-fold increase in CCR3 and betac mRNA
Title: Spatial and temporal expression of CCR3 and the common beta chain of the IL-3, IL-5 and GM-CSF receptor in the nasal epithelium and lymphoid tissues in a rat model of allergic rhinitis.
Down-regulation of constitutively expressed surface CCR3 levels by interleukin 1-beta in an insulin-producing model system implies receptor internalization for re-utilization or destruction, secretion or both.
Title: Localization and expression of CCR3 and CCR5 by interleukin-1 beta in the RIN-5AH insulin-producing model system: a protective mechanism involving down-regulation of chemokine receptors.
demonstrated that CCR3 is absent from the testes
Title: Study of the HIV-1 receptors CD4, CXCR4, CCR5 and CCR3 in the human and rat testis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables C-C chemokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine binding	IEA Inferred from Electronic Annotation more info
enables C-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables C-C chemokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables C-C chemokine receptor activity	IEA Inferred from Electronic Annotation more info
enables C-C chemokine receptor activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in angioblast cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in mast cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C chemokine receptor type 3

Names: C-C CKR-3; CC-CKR-3; CCR-3; CKR3; chemokine (C-C motif) receptor 3; chemokine (C-C) receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053958.2 → NP_446410.1 C-C chemokine receptor type 3

See identical proteins and their annotated locations for NP_446410.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

O54814, O55169

UniProtKB/TrEMBL

A0A0A0MXU9, A6I4D1

Conserved Domains (1) summary

cd15185
Location:39 → 316

7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

132463533..132511601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080707.2 → XP_038936635.1 C-C chemokine receptor type 3 isoform X1

UniProtKB/Swiss-Prot

O54814, O55169

UniProtKB/TrEMBL

A0A0A0MXU9, A6I4D1

Related

ENSRNOP00000008809.4

Conserved Domains (1) summary

cd15185
Location:39 → 316

7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_039080708.2 → XP_038936636.1 C-C chemokine receptor type 3 isoform X1

UniProtKB/Swiss-Prot

O54814, O55169

UniProtKB/TrEMBL

A0A0A0MXU9, A6I4D1

Related

ENSRNOP00000093164.1

Conserved Domains (1) summary

cd15185
Location:39 → 316

7tmA_CCR3; CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_063264781.1 → XP_063120851.1 C-C chemokine receptor type 3 isoform X1

UniProtKB/TrEMBL

A0A0A0MXU9, A6I4D1