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Polr2g RNA polymerase II subunit G [ Rattus norvegicus (Norway rat) ]

Gene ID: 117017, updated on 11-Apr-2024

Summary

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Official Symbol
Polr2gprovided by RGD
Official Full Name
RNA polymerase II subunit Gprovided by RGD
Primary source
RGD:621284
See related
Ensembl:ENSRNOG00000019439 AllianceGenome:RGD:621284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rpb7
Summary
Predicted to enable single-stranded DNA binding activity; single-stranded RNA binding activity; and translation initiation factor binding activity. Involved in apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II, core complex. Predicted to be active in P-body. Orthologous to human POLR2G (RNA polymerase II subunit G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 300.5), Spleen (RPKM 218.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215118278..215125389, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205689160..205692537, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224991250..224998355, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 179B Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene zinc finger and BTB domain containing 3 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line. Khalyfa A, et al. Mol Vis, 2007 Feb 28. PMID 17356516, Free PMC Article
  2. Structure and function of RNA polymerase II elongation factor ELL. Identification of two overlapping ELL functional domains that govern its interaction with polymerase and the ternary elongation complex. Shilatifard A, et al. J Biol Chem, 1997 Aug 29. PMID 9268387
  3. TFIIB-related factors in RNA polymerase I transcription. Knutson BA, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 22960599, Free PMC Article
  4. Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes. Kershnar E, et al. J Biol Chem, 1998 Dec 18. PMID 9852112
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72732, MGC72993

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase II, core complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase II, core complex ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II, core complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase II subunit RPB7
Names
DNA-directed RNA polymerase II subunit G
RNA polymerase II subunit B7
polymerase (RNA) II (DNA directed) polypeptide G
polymerase (RNA) II subunit G
NP_446400.1
XP_063122437.1
XP_063122446.1
XP_063122459.1
XP_063122474.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053948.4 → NP_446400.1  DNA-directed RNA polymerase II subunit RPB7

    See identical proteins and their annotated locations for NP_446400.1

    Status: PROVISIONAL

    Source sequence(s)
    Z71925
    UniProtKB/Swiss-Prot
    P62489
    UniProtKB/TrEMBL
    A0A8I6GKH4, A6HZU1
    Related
    ENSRNOP00000026313.5, ENSRNOT00000026313.8
    Conserved Domains (1) summary
    PTZ00162
    Location:1 → 169
    PTZ00162; DNA-directed RNA polymerase II subunit 7; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    215118278..215125389 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266376.1 → XP_063122446.1  DNA-directed RNA polymerase II subunit RPB7 isoform X2

    UniProtKB/Swiss-Prot
    P62489
    UniProtKB/TrEMBL
    A6HZU1

  2. XM_063266389.1 → XP_063122459.1  DNA-directed RNA polymerase II subunit RPB7 isoform X2

    UniProtKB/Swiss-Prot
    P62489
    UniProtKB/TrEMBL
    A6HZU1

  3. XM_063266404.1 → XP_063122474.1  DNA-directed RNA polymerase II subunit RPB7 isoform X2

    UniProtKB/Swiss-Prot
    P62489
    UniProtKB/TrEMBL
    A6HZU1

  4. XM_063266367.1 → XP_063122437.1  DNA-directed RNA polymerase II subunit RPB7 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62489.1 GenPept UniProtKB/Swiss-Prot:P62489

Gene LinkOut

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