Aldoc aldolase C, fructose-bisphosphate [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aldocprovided by MGI
Official Full Name: aldolase C, fructose-bisphosphateprovided by MGI
Primary source: MGI:MGI:101863
See related: Ensembl:ENSMUSG00000017390 AllianceGenome:MGI:101863
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aldo3; Scrg2
Summary: This gene encodes a member of the aldolase family of enzymes that is mainly expressed in neuronal tissues. The encoded protein is an enzyme of the glycolysis pathway, and catalyzes the conversion of fructose-1,6-bisphosphate to glyceraldehyde-3-phosphate and dihydroxyacetone phosphate. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression: Biased expression in cerebellum adult (RPKM 424.1), cortex adult (RPKM 249.9) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78213899..78218607)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78323073..78327781)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the Neurog2(-/-) mouse, in addition to the normal Purkinje cell expression, zebrin II is also expressed in a population of cells with a morphology characteristic of microglia. This identity was confirmed by double immunohistochemistry for zebrin II and the microglial marker, Iba1. The expression of zebrin II in cerebellar microglia is not restricted by zone or stripe or lamina.
Title: Zebrin II Is Ectopically Expressed in Microglia in the Cerebellum of Neurogenin 2 Null Mice.
High levels of Aldoc expression in the retina and cerebellar Purkinje and cartwheel cells in the ventral cochlear nucleus, moderate expression levels in astrocytes, and a newly recognized expression in the inner ear and the dorsal root ganglion.
Title: Detailed expression pattern of aldolase C (Aldoc) in the cerebellum, retina and other areas of the CNS studied in Aldoc-Venus knock-in mice.
Studies indicate that zebrin II expression is essential for enhancing understanding of the pathogenesis of hereditary cerebellar ataxic mutants.
Title: Zebrin II expressing Purkinje cell phenotype-related and -unrelated cerebellar abnormalities in Cav2.1 mutant, rolling mouse Nagoya.
Chronic morphine administration induces over-expression of Aldoc with reduction of CREB phosphorylation in the mouse hippocampus.
Title: Chronic morphine administration induces over-expression of aldolase C with reduction of CREB phosphorylation in the mouse hippocampus.
Ebf2 regulates the expression of genes associated with the zebrin II+ Purkinje cell phenotype and that the zebrin II- Purkinje cell subtype is specified independently.
Title: Purkinje cell subtype specification in the cerebellar cortex: early B-cell factor 2 acts to repress the zebrin II-positive Purkinje cell phenotype.
The results from the present study indicate that aldolase C provides marked neuroprotection to PCs after trauma and excitotoxicity.
Title: Aldolase C-positive cerebellar Purkinje cells are resistant to delayed death after cerebral trauma and AMPA-mediated excitotoxicity.
the aldolase C compartments and olivocerebellar projection are organized according to a common fundamental organization in the mouse and rat
Title: Identification of aldolase C compartments in the mouse cerebellar cortex by olivocerebellar labeling.
A species difference between mouse and rat is found in both mRNA and protein expression of zebrin II/aldolase C in the cerebellum. There also appears to be a transition in expression that occurs in vivo between postnatal days 8 and 10.
Title: Development of cerebellar modules: extrinsic control of late-phase zebrin II pattern and the exploration of rat/mouse species differences.
Aldolase C (EC 4.1.2.13) is a brain-specific aldolase isoform and a putative target of the transcription factor hypoxia-inducible factor (HIF)-1
Title: Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells.
The selective regulation of AldC/zebrin may contribute to a shift in nutrient metabolism during pregnancy and lactation to facilitate epithelial growth and biosynthesis of milk constituents.
Title: Aldolase C/zebrin gene regulation by prolactin during pregnancy and lactation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Seg17 (e-PCR), detects polymorphism
- UniSTS:141070

Aldoc (e-PCR), detects polymorphism
- UniSTS:506726

AU040929 (e-PCR)
- UniSTS:160128

AI847350 (e-PCR)
- UniSTS:165777

D10Arb9 (e-PCR), detects polymorphism
- UniSTS:226265

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables fructose-bisphosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose-bisphosphate aldolase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose-bisphosphate aldolase activity	ISO Inferred from Sequence Orthology more info
enables fructose-bisphosphate aldolase activity	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 1,6-bisphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fructose-bisphosphate aldolase C

Names: brain-type aldolase; scrapie responsive gene 2; scrapie-responsive protein 2; zebrin II

NP_001290352.1

EC 4.1.2.13

NP_033787.2

EC 4.1.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001303423.1 → NP_001290352.1 fructose-bisphosphate aldolase C

See identical proteins and their annotated locations for NP_001290352.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL591070

Consensus CDS

CCDS25099.1

UniProtKB/Swiss-Prot

P05063, Q64011, Q8CA91, Q99K96, Q9DBA4, Q9JK32

Related

ENSMUSP00000017534.9, ENSMUST00000017534.15

Conserved Domains (1) summary

pfam00274
Location:15 → 363

Glycolytic; Fructose-bisphosphate aldolase class-I
NM_009657.4 → NP_033787.2 fructose-bisphosphate aldolase C

See identical proteins and their annotated locations for NP_033787.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AL591070

Consensus CDS

CCDS25099.1

UniProtKB/Swiss-Prot

P05063, Q64011, Q8CA91, Q99K96, Q9DBA4, Q9JK32

Related

ENSMUSP00000099536.4, ENSMUST00000102478.4

Conserved Domains (1) summary

pfam00274
Location:15 → 363

Glycolytic; Fructose-bisphosphate aldolase class-I