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Slc7a9 solute carrier family 7 member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116726, updated on 3-Apr-2024

Summary

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Official Symbol
Slc7a9provided by RGD
Official Full Name
solute carrier family 7 member 9provided by RGD
Primary source
RGD:619905
See related
Ensembl:ENSRNOG00000012344 AllianceGenome:RGD:619905
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables amino acid transmembrane transporter activity. Involved in amino acid transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC7A9 (solute carrier family 7 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 399.3) See more
Orthologs
human mouse all
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Genomic context

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See Slc7a9 in Genome Data Viewer
Location:
1q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (97246253..97269546)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (88109517..88132653)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (91709034..91738492)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene FA core complex associated protein 24 Neighboring gene centrosomal protein 89 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene tudor domain containing 12 Neighboring gene nudix hydrolase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter. Shigeta Y, et al. Kidney Int, 2006 Apr. PMID 16609684
  2. Identification of an amino acid transporter associated with the cystinuria-related type II membrane glycoprotein. Chairoungdua A, et al. J Biol Chem, 1999 Oct 8. PMID 10506124
  3. Non-type I cystinuria caused by mutations in SLC7A9, encoding a subunit (bo,+AT) of rBAT. Feliubadaló L, et al. Nat Genet, 1999 Sep. PMID 10471498
  4. Co-localization and interaction of b0,+-type amino acid transporter 1 (BAT1) with caveolin-1 in rat kidney. Kwak JO, et al. J Nephrol, 2005 Nov-Dec. PMID 16358225
  5. rBAT-b(0,+)AT heterodimer is the main apical reabsorption system for cystine in the kidney. Fernández E, et al. Am J Physiol Renal Physiol, 2002 Sep. PMID 12167606

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC114282

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-cystine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-cystine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-cystine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables broad specificity neutral L-amino acid:basic L-amino acid antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables broad specificity neutral L-amino acid:basic L-amino acid antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peptide antigen binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-cystine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-cystine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-cystine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B(0,+)-type amino acid transporter 1
Names
b(0,+)AT
glycoprotein-associated amino acid transporter b0,+AT1
solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
solute carrier family 7 (cationic amino acid transporter, y+ system), member 9
solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053929.1 → NP_446381.1  B(0,+)-type amino acid transporter 1

    See identical proteins and their annotated locations for NP_446381.1

    Status: PROVISIONAL

    Source sequence(s)
    AB029559
    UniProtKB/Swiss-Prot
    P82252, Q4KM04
    UniProtKB/TrEMBL
    A6JAB3
    Related
    ENSRNOP00000016919.2, ENSRNOT00000016919.5
    Conserved Domains (1) summary
    TIGR00911
    Location:13 → 484
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    97246253..97269546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008759103.4 → XP_008757325.1  B(0,+)-type amino acid transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_008757325.1

    UniProtKB/Swiss-Prot
    P82252, Q4KM04
    UniProtKB/TrEMBL
    A6JAB3
    Conserved Domains (1) summary
    TIGR00911
    Location:13 → 484
    2A0308; L-type amino acid transporter

  2. XM_063266018.1 → XP_063122088.1  B(0,+)-type amino acid transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P82252, Q4KM04
    UniProtKB/TrEMBL
    A6JAB3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82252.1 GenPept UniProtKB/Swiss-Prot:P82252

Gene LinkOut

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