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Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 116720, updated on 11-Apr-2024

Summary

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Official Symbol
Pik3c2gprovided by RGD
Official Full Name
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gammaprovided by RGD
Primary source
RGD:620231
See related
Ensembl:ENSRNOG00000034228 AllianceGenome:RGD:620231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LRRG00132
Summary
Enables 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; and viral RNA genome replication. Located in Golgi apparatus; nuclear envelope; and plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 93.3) and Uterus (RPKM 3.7) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q44
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (174215527..174583378)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (172483752..172851623)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (173732196..174102502)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547697 Neighboring gene RERG like Neighboring gene uncharacterized LOC120102423 Neighboring gene phospholipase C, zeta 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning. Carini R, et al. Gastroenterology, 2004 Sep. PMID 15362046
  2. Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Yang KY, et al. Cell Signal, 2003 Feb. PMID 12464394
  3. Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells. Yu W, et al. Leuk Lymphoma, 2010 Jun. PMID 20536348, Free PMC Article
  4. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. Daimon M, et al. Biochem Biophys Res Commun, 2008 Jan 18. PMID 17991425
  5. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. Shanley LJ, et al. J Physiol, 2002 Dec 15. PMID 12482897, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leptin, via PI 3-kinase-driven activation of BK channels, elicits novel mechanism for controlling neuronal excitability. Novel action of leptin could provide an alternative therapeutic target in the management of epilepsy.
    Title: Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.
  2. By regulating PKC-/delta-dependent signals, PI3K can play a key role in the development of hepatic tolerance to hypoxia/reperfusion.
    Title: Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
  3. PI3-Kgamma directly participates in multiple in vivo pathways involved in regulating neutrophil apoptosis.
    Title: Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
Names
PI3K-C2-gamma
PI3K-C2gamma
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide
phosphoinositide 3-Kinase-C2-gamma
phosphoinositide-3-kinase, class 2, gamma polypeptide
ptdIns-3-kinase C2 gamma
ptdIns-3-kinase C2 subunit gamma
NP_446375.1
XP_038962876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053923.1 → NP_446375.1  phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

    See identical proteins and their annotated locations for NP_446375.1

    Status: PROVISIONAL

    Source sequence(s)
    AB009636
    UniProtKB/Swiss-Prot
    O70173
    UniProtKB/TrEMBL
    A6IMM4
    Related
    ENSRNOP00000043855.4, ENSRNOT00000041499.5
    Conserved Domains (6) summary
    cd04012
    Location:535 → 697
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cl00271
    Location:712 → 879
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:310 → 368
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl02563
    Location:1267 → 1367
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl14603
    Location:1389 → 1501
    C2; C2 domain
    cl21453
    Location:886 → 1238
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    174215527..174583378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039106948.2 → XP_038962876.1  phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1

    UniProtKB/TrEMBL
    A6IMM4, D3ZE56
    Conserved Domains (6) summary
    cd04012
    Location:535 → 697
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cl00271
    Location:712 → 879
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    cl02484
    Location:310 → 368
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl02563
    Location:1267 → 1367
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
    cl14603
    Location:1389 → 1501
    C2; C2 domain
    cl21453
    Location:886 → 1238
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_010065609.1 RNA Sequence

  2. XR_005503143.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70173.1 GenPept UniProtKB/Swiss-Prot:O70173

Gene LinkOut

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