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Acacb acetyl-CoA carboxylase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 116719, updated on 13-Apr-2024

Summary

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Official Symbol
Acacbprovided by RGD
Official Full Name
acetyl-CoA carboxylase betaprovided by RGD
Primary source
RGD:620500
See related
Ensembl:ENSRNOG00000000658 AllianceGenome:RGD:620500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acc2
Summary
Enables biotin binding activity. Involved in response to organic cyclic compound and response to xenobiotic stimulus. Located in mitochondrion. Used to study fatty liver disease. Orthologous to human ACACB (acetyl-CoA carboxylase beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 318.0), Muscle (RPKM 203.6) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acacb in Genome Data Viewer
Location:
12q16
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48026394..48138214, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42365800..42477651, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48127149..48238969, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 10 Neighboring gene myosin IH Neighboring gene forkhead box N4 Neighboring gene uncharacterized LOC134481305 Neighboring gene alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase Neighboring gene uracil-DNA glycosylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta. Imbriolo J, et al. Biochem Biophys Res Commun, 2014 Sep 26. PMID 25195817
  2. Isolation and characterization of cDNA encoding rat heart type acetyl-CoA carboxylase. Abe K, et al. Biochim Biophys Acta, 1998 Jul 9. PMID 9655932
  3. The Warble Fly Orders. Watson J. Vet Rec, 1978 Oct 14. PMID 734875
  4. Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis. Ritterhoff J, et al. Circ Res, 2020 Jan 17. PMID 31709908, Free PMC Article
  5. Characterization of recombinant human acetyl-CoA carboxylase-2 steady-state kinetics. Kaushik VK, et al. Biochim Biophys Acta, 2009 Jun. PMID 19236960

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta in myoblasts.
    Title: The hexosamine biosynthetic pathway induces gene promoter activity of acetyl-CoA carboxylase beta.
  2. highlight site-specific impacts of hypothalamic acetyl-CoA carboxylase activation in leptin's anorectic signaling cascade.
    Title: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
  3. data support a potential role for Acetyl-CoA carboxylases (ACC) 1 and 2 in the development of obesity and diabetes in rats; results point towards major differences in ACC tissue distribution between humans and rats
    Title: Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes.
  4. Human leptin increased AMP-activated protein kinase-alpha and Acacb phosphorylation in rat skeletal muscle of lean, but not obese rats.
    Title: AMPK and ACC phosphorylation: effect of leptin, muscle fibre type and obesity.
  5. study provides evidence that acetyl-CoA carboxylase beta expression in liver is regulated at the transcriptional level by the direct interaction of sterol regulatory element binding protein-1 with promoter II
    Title: Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.
  6. Acc regulation in rat in response to exercise
    Title: Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.
  7. differential regulation of ACCbeta gene expression between tissues
    Title: Alternative usages of multiple promoters of the acetyl-CoA carboxylase beta gene are related to differential transcriptional regulation in human and rodent tissues.
  8. Skeletal muscle ACC is more potently inhibited by palmitoyl-CoA after having been phosphorylated by AMPK.
    Title: Effect of phosphorylation by AMP-activated protein kinase on palmitoyl-CoA inhibition of skeletal muscle acetyl-CoA carboxylase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetyl-CoA carboxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables biotin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular aspartate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular glutamate homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lactic acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malonyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pentose-phosphate shunt IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of heart growth ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleotide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cardiac muscle hypertrophy in response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nutrient levels ISO
Inferred from Sequence Orthology
more info
  
involved_in response to organic cyclic compound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in tricarboxylic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial fatty acid beta-oxidation multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acetyl-CoA carboxylase 2
Names
acetyl-Coenzyme A carboxylase 2
acetyl-Coenzyme A carboxylase beta
NP_446374.2
XP_017453731.1
XP_017453732.1
XP_017453734.1
XP_017453735.1
XP_017453736.1
XP_017453737.1
XP_038944959.1
XP_063127084.1
XP_063127085.1
XP_063127086.1
XP_063127087.1
XP_063127088.1
XP_063127089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053922.2 → NP_446374.2  acetyl-CoA carboxylase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    Q1HEC0
    Conserved Domains (4) summary
    COG0439
    Location:257 → 760
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:892 → 958
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam01039
    Location:1777 → 2331
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:959 → 1685
    ACC_central; Acetyl-CoA carboxylase, central region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    48026394..48138214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271014.1 → XP_063127084.1  acetyl-CoA carboxylase 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K5L6

  2. XM_017598246.3 → XP_017453735.1  acetyl-CoA carboxylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1F2, Q1HEC0
    Related
    ENSRNOP00000071816.2

  3. XM_017598242.3 → XP_017453731.1  acetyl-CoA carboxylase 2 isoform X1

    UniProtKB/TrEMBL
    Q1HEC0

  4. XM_017598243.3 → XP_017453732.1  acetyl-CoA carboxylase 2 isoform X1

    UniProtKB/TrEMBL
    Q1HEC0

  5. XM_063271016.1 → XP_063127086.1  acetyl-CoA carboxylase 2 isoform X4

  6. XM_063271015.1 → XP_063127085.1  acetyl-CoA carboxylase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K1F2

  7. XM_017598245.3 → XP_017453734.1  acetyl-CoA carboxylase 2 isoform X1

    UniProtKB/TrEMBL
    Q1HEC0

  8. XM_017598247.3 → XP_017453736.1  acetyl-CoA carboxylase 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6ART3
    Related
    ENSRNOP00000094530.1

  9. XM_063271018.1 → XP_063127088.1  acetyl-CoA carboxylase 2 isoform X8

  10. XM_063271017.1 → XP_063127087.1  acetyl-CoA carboxylase 2 isoform X7

  11. XM_017598248.3 → XP_017453737.1  acetyl-CoA carboxylase 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6ART3

  12. XM_063271019.1 → XP_063127089.1  acetyl-CoA carboxylase 2 isoform X9

  13. XM_039089031.2 → XP_038944959.1  acetyl-CoA carboxylase 2 isoform X10

    Conserved Domains (3) summary
    COG0439
    Location:257 → 760
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    pfam00364
    Location:892 → 958
    Biotin_lipoyl; Biotin-requiring enzyme
    pfam08326
    Location:959 → 1508
    ACC_central; Acetyl-CoA carboxylase, central region
Nucleotide Protein Strain
Heading Accession and Version

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