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Aldh2 aldehyde dehydrogenase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 11669, updated on 22-Apr-2024

Summary

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Official Symbol
Aldh2provided by MGI
Official Full Name
aldehyde dehydrogenase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:99600
See related
Ensembl:ENSMUSG00000029455 AllianceGenome:MGI:99600
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ahd5; ALDHI; Ahd-5; AHD-M1; ALDH-E2
Summary
Predicted to enable NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in several processes, including behavioral response to ethanol; cellular detoxification of aldehyde; and intrinsic apoptotic signaling pathway in response to oxidative stress. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); diabetic neuropathy; and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 574.9), liver adult (RPKM 432.0) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 61.86 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (121704090..121731887, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (121566027..121593824, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 1a Neighboring gene MAP kinase-activated protein kinase 5 Neighboring gene STARR-seq mESC enhancer starr_14259 Neighboring gene STARR-positive B cell enhancer ABC_E9092 Neighboring gene STARR-positive B cell enhancer ABC_E11301 Neighboring gene STARR-seq mESC enhancer starr_14260 Neighboring gene STARR-seq mESC enhancer starr_14261 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 12 Neighboring gene acyl-Coenzyme A dehydrogenase family, member 10 Neighboring gene BRCA1 associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway. Jin J, et al. J Immunol Res, 2023. PMID 37064008, Free PMC Article
  2. Aldehyde Dehydrogenase 2 Protects the Kidney from Ischemia-Reperfusion Injury by Suppressing the IκBα/NF-κB/IL-17C Pathway. Chen Y, et al. Oxid Med Cell Longev, 2023. PMID 36865346, Free PMC Article
  3. SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant. Guo H, et al. Sci Transl Med, 2023 Jan 25. PMID 36696485, Free PMC Article
  4. Chronic alcohol metabolism results in DNA repair infidelity and cell cycle-induced senescence in neurons. Sun JK, et al. Aging Cell, 2023 Feb. PMID 36691110, Free PMC Article
  5. [ALDH2 attenuates LPS-induced increase of brain microvascular endothelial cell permeability by promoting fusion and inhibiting fission of the mitochondria]. Wang S, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2022 Dec 20. PMID 36651258, Free PMC Article

See all (207) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.
    Title: Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice.
  2. Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.
    Title: Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.
  3. LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2.
    Title: LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2.
  4. ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
    Title: ALDH2 deficiency exacerbates MCD-diet induced MASLD by modulating bile acid metabolism.
  5. Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde-potentiated pro-inflammatory responses and glycolysis in macrophages.
    Title: Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde-potentiated pro-inflammatory responses and glycolysis in macrophages.
  6. ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway.
    Title: ALDH2 mitigates LPS-induced cardiac dysfunction, inflammation, and apoptosis through the cGAS/STING pathway.
  7. Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis.
    Title: Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis.
  8. A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.
    Title: A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.
  9. ALDH2 activation attenuates oxygen-glucose deprivation/reoxygenation-induced cell apoptosis, pyroptosis, ferroptosis and autophagy.
    Title: ALDH2 activation attenuates oxygen-glucose deprivation/reoxygenation-induced cell apoptosis, pyroptosis, ferroptosis and autophagy.
  10. [Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier and balances mitochondrial dynamics in mice with acute lung injury].
    Title: [Acetaldehyde dehydrogenase 2 ameliorates lung endothelial barrier and balances mitochondrial dynamics in mice with acute lung injury].
Submit: New GeneRIF Correction See all GeneRIFs (128)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables NADH binding ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nitroglycerin reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetaldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in aldehyde catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in behavioral response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular detoxification of aldehyde ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dopamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of serotonin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase, mitochondrial
Names
ALDH class 2
NP_001295379.1
NP_033786.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308450.1 → NP_001295379.1  aldehyde dehydrogenase, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate 3' exons and has a 3' end that extends into an intron compared to variant 1. The resulting isoform (2) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK043506, AK165032, CO039039
    Consensus CDS
    CCDS84951.1
    UniProtKB/TrEMBL
    A0A0G2JEU1, Q3TVM2, Q3U6I3, Q3U9J7
    Related
    ENSMUSP00000142906.2, ENSMUST00000129753.8
    Conserved Domains (1) summary
    cd07141
    Location:33 → 471
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like

  2. NM_009656.4 → NP_033786.1  aldehyde dehydrogenase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_033786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK163452, AK165032, AW050084
    Consensus CDS
    CCDS19638.1
    UniProtKB/Swiss-Prot
    P47738
    UniProtKB/TrEMBL
    Q3TVM2, Q3U6I3, Q3U9J7, Q544B1
    Related
    ENSMUSP00000031411.9, ENSMUST00000031411.15
    Conserved Domains (2) summary
    cd07141
    Location:33 → 513
    ALDH_F1AB_F2_RALDH1; NAD+-dependent retinal dehydrogenase 1, ALDH families 1A, 1B, and 2-like
    PLN02466
    Location:3 → 518
    PLN02466; aldehyde dehydrogenase family 2 member

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    121704090..121731887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47738.1 GenPept UniProtKB/Swiss-Prot:P47738

Gene LinkOut

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