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Oplah 5-oxoprolinase (ATP-hydrolysing) [ Rattus norvegicus (Norway rat) ]

Gene ID: 116684, updated on 11-Apr-2024

Summary

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Official Symbol
Oplahprovided by RGD
Official Full Name
5-oxoprolinase (ATP-hydrolysing)provided by RGD
Primary source
RGD:620956
See related
Ensembl:ENSRNOG00000011781 AllianceGenome:RGD:620956
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 5-oxoprolinase (ATP-hydrolyzing) activity and identical protein binding activity. Predicted to be involved in glutathione metabolic process. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 348.2), Liver (RPKM 107.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (109892136..109932403, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108011472..108051751, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117353951..117394205, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093816 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene transfer RNA leucine (anticodon AAG) 12 Neighboring gene sphingomyelin phosphodiesterase 5 Neighboring gene exosome component 4 Neighboring gene glycosylphosphatidylinositol anchor attachment 1 Neighboring gene cytochrome c-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The amino acid sequence of rat kidney 5-oxo-L-prolinase determined by cDNA cloning. Ye GJ, et al. J Biol Chem, 1996 Dec 13. PMID 8943290
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105359

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5-oxoprolinase (ATP-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-oxoprolinase (ATP-hydrolyzing) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
5-oxoprolinase
Names
5-OPase
5-oxo-L-prolinase
pyroglutamase
NP_446356.1
XP_006241833.1
XP_006241834.1
XP_006241835.1
XP_006241837.1
XP_038934184.1
XP_038934185.1
XP_038934186.1
XP_038934187.1
XP_063118944.1
XP_063118945.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053904.1 → NP_446356.1  5-oxoprolinase

    See identical proteins and their annotated locations for NP_446356.1

    Status: PROVISIONAL

    Source sequence(s)
    U70825
    UniProtKB/TrEMBL
    A0A8L2Q8T4
    Related
    ENSRNOP00000074523.2, ENSRNOT00000080724.2
    Conserved Domains (4) summary
    PLN02666
    Location:1 → 1258
    PLN02666; 5-oxoprolinase
    pfam01968
    Location:231 → 513
    Hydantoinase_A; Hydantoinase/oxoprolinase
    pfam02538
    Location:734 → 1256
    Hydantoinase_B; Hydantoinase B/oxoprolinase
    pfam05378
    Location:9 → 212
    Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    109892136..109932403 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078258.2 → XP_038934186.1  5-oxoprolinase isoform X4

    UniProtKB/Swiss-Prot
    P97608, Q5U3Z8
    UniProtKB/TrEMBL
    A0A8L2Q8T4, A6HS77
    Conserved Domains (1) summary
    PLN02666
    Location:1 → 1258
    PLN02666; 5-oxoprolinase

  2. XM_039078259.2 → XP_038934187.1  5-oxoprolinase isoform X4

    UniProtKB/Swiss-Prot
    P97608, Q5U3Z8
    UniProtKB/TrEMBL
    A0A8L2Q8T4, A6HS77
    Conserved Domains (1) summary
    PLN02666
    Location:1 → 1258
    PLN02666; 5-oxoprolinase

  3. XM_006241775.5 → XP_006241837.1  5-oxoprolinase isoform X4

    See identical proteins and their annotated locations for XP_006241837.1

    UniProtKB/Swiss-Prot
    P97608, Q5U3Z8
    UniProtKB/TrEMBL
    A0A8L2Q8T4, A6HS77
    Conserved Domains (1) summary
    PLN02666
    Location:1 → 1258
    PLN02666; 5-oxoprolinase

  4. XM_039078257.2 → XP_038934185.1  5-oxoprolinase isoform X4

    UniProtKB/Swiss-Prot
    P97608, Q5U3Z8
    UniProtKB/TrEMBL
    A0A8L2Q8T4, A6HS77
    Conserved Domains (1) summary
    PLN02666
    Location:1 → 1258
    PLN02666; 5-oxoprolinase

  5. XM_006241773.5 → XP_006241835.1  5-oxoprolinase isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZZD3, A0A8L2R932
    Related
    ENSRNOP00000084556.1
    Conserved Domains (5) summary
    PLN02666
    Location:97 → 1354
    PLN02666; 5-oxoprolinase
    pfam01968
    Location:327 → 609
    Hydantoinase_A; Hydantoinase/oxoprolinase
    pfam02538
    Location:830 → 1352
    Hydantoinase_B; Hydantoinase B/oxoprolinase
    pfam05378
    Location:105 → 308
    Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
    cl19252
    Location:4 → 44
    MreC; rod shape-determining protein MreC

  6. XM_006241772.5 → XP_006241834.1  5-oxoprolinase isoform X2

    UniProtKB/TrEMBL
    A0A8L2R932
    Conserved Domains (5) summary
    PLN02666
    Location:136 → 1392
    PLN02666; 5-oxoprolinase
    pfam01968
    Location:366 → 648
    Hydantoinase_A; Hydantoinase/oxoprolinase
    pfam02538
    Location:869 → 1390
    Hydantoinase_B; Hydantoinase B/oxoprolinase
    pfam05378
    Location:144 → 347
    Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
    cl19252
    Location:4 → 44
    MreC; rod shape-determining protein MreC

  7. XM_006241771.5 → XP_006241833.1  5-oxoprolinase isoform X1

    UniProtKB/TrEMBL
    A0A8L2R932
    Conserved Domains (5) summary
    PLN02666
    Location:136 → 1393
    PLN02666; 5-oxoprolinase
    pfam01968
    Location:366 → 648
    Hydantoinase_A; Hydantoinase/oxoprolinase
    pfam02538
    Location:869 → 1391
    Hydantoinase_B; Hydantoinase B/oxoprolinase
    pfam05378
    Location:144 → 347
    Hydant_A_N; Hydantoinase/oxoprolinase N-terminal region
    cl19252
    Location:4 → 44
    MreC; rod shape-determining protein MreC

  8. XM_039078256.2 → XP_038934184.1  5-oxoprolinase isoform X4

    UniProtKB/Swiss-Prot
    P97608, Q5U3Z8
    UniProtKB/TrEMBL
    A0A8L2Q8T4, A6HS77
    Conserved Domains (1) summary
    PLN02666
    Location:1 → 1258
    PLN02666; 5-oxoprolinase

  9. XM_063262874.1 → XP_063118944.1  5-oxoprolinase isoform X5

  10. XM_063262875.1 → XP_063118945.1  5-oxoprolinase isoform X6

RNA

  1. XR_005486539.2 RNA Sequence

  2. XR_005486538.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97608.2 GenPept UniProtKB/Swiss-Prot:P97608

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