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Ptpru protein tyrosine phosphatase, receptor type, U [ Rattus norvegicus (Norway rat) ]

Gene ID: 116680, updated on 4-Jan-2025

Summary

Official Symbol
Ptpruprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Uprovided by RGD
Primary source
RGD:620782
See related
EnsemblRapid:ENSRNOG00000013515 AllianceGenome:RGD:620782
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable beta-catenin binding activity and protein tyrosine phosphatase activity. Involved in animal organ regeneration and response to glucocorticoid. Predicted to be located in cell-cell junction. Biomarker of membranous glomerulonephritis and nephrosis. Orthologous to human PTPRU (protein tyrosine phosphatase receptor type U). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Uterus (RPKM 40.5), Kidney (RPKM 36.0) and 9 other tissues See more
Orthologs
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Genomic context

See Ptpru in Genome Data Viewer
Location:
5q36
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149234624..149308857, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (143950542..144024791, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (149922374..149996352, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479035 Neighboring gene uncharacterized LOC134479036 Neighboring gene uncharacterized LOC134486998 Neighboring gene mitochondrial trans-2-enoyl-CoA reductase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cell-cell junction  
located_in membrane  

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase U
Names
R-ptp-psi
NP_001178504.1
NP_001401978.1
XP_006239060.1
XP_008762352.1
XP_017448609.1
XP_017448610.1
XP_017448611.1
XP_038965082.1
XP_038965083.1
XP_038965084.1
XP_063143141.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191575.2NP_001178504.1  receptor-type tyrosine-protein phosphatase U isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K3H0
    Conserved Domains (5) summary
    smart00137
    Location:22186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:386481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:12321438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494577
    fn3; Fibronectin type III domain
    cl28904
    Location:9431147
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. NM_001415049.1NP_001401978.1  receptor-type tyrosine-protein phosphatase U isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K3H0
    Related
    ENSRNOP00000104366.1, ENSRNOT00000158638.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    149234624..149308857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109155.2XP_038965083.1  receptor-type tyrosine-protein phosphatase U isoform X4

    UniProtKB/TrEMBL
    A0A0G2K3H0
    Conserved Domains (5) summary
    smart00137
    Location:22186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:386481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:12291435
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:494577
    fn3; Fibronectin type III domain
    cl28904
    Location:9431144
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_017593121.3XP_017448610.1  receptor-type tyrosine-protein phosphatase U isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3H0
  3. XM_039109156.2XP_038965084.1  receptor-type tyrosine-protein phosphatase U isoform X7

    UniProtKB/TrEMBL
    A0A0G2K3H0
    Conserved Domains (4) summary
    smart00137
    Location:22186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:386481
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:494577
    fn3; Fibronectin type III domain
    cl28904
    Location:9431153
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_017593120.3XP_017448609.1  receptor-type tyrosine-protein phosphatase U isoform X1

    UniProtKB/TrEMBL
    A0A0G2K3H0
    Related
    ENSRNOP00000030956.5, ENSRNOT00000036148.6
  5. XM_006238998.4XP_006239060.1  receptor-type tyrosine-protein phosphatase U isoform X6

    UniProtKB/TrEMBL
    A0A0G2K3H0
    Conserved Domains (7) summary
    cd06263
    Location:27186
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:11621425
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:9121130
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:484585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:291366
    fn3; Fibronectin type III domain
    pfam00102
    Location:9081130
    Y_phosphatase; Protein-tyrosine phosphatase
  6. XM_017593122.3XP_017448611.1  receptor-type tyrosine-protein phosphatase U isoform X5

    UniProtKB/TrEMBL
    A0A0G2K3H0
  7. XM_063287071.1XP_063143141.1  receptor-type tyrosine-protein phosphatase U isoform X8

    UniProtKB/TrEMBL
    F1MAG7
  8. XM_039109154.2XP_038965082.1  receptor-type tyrosine-protein phosphatase U isoform X3

    UniProtKB/TrEMBL
    A0A0G2K3H0
    Conserved Domains (5) summary
    smart00137
    Location:20180
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd00063
    Location:380475
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14637
    Location:12321438
    R-PTPc-U-2; PTP domain of receptor-type tyrosine-protein phosphatase U, repeat 2
    pfam00041
    Location:488571
    fn3; Fibronectin type III domain
    cl28904
    Location:9371147
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  9. XM_008764130.4XP_008762352.1  receptor-type tyrosine-protein phosphatase U isoform X9

    Conserved Domains (5) summary
    cd06263
    Location:27186
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00137
    Location:22186
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00410
    Location:196282
    IG_like; Immunoglobulin like
    cd00063
    Location:484585
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:291366
    fn3; Fibronectin type III domain
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