U.S. flag

An official website of the United States government

Vcp valosin-containing protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 116643, updated on 4-Jan-2025

Summary

Official Symbol
Vcpprovided by RGD
Official Full Name
valosin-containing proteinprovided by RGD
Primary source
RGD:621595
See related
EnsemblRapid:ENSRNOG00000034242 AllianceGenome:RGD:621595
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ATP hydrolysis activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of ubiquitin-dependent protein catabolic process; and retrograde protein transport, ER to cytosol. Located in cytosol. Part of VCP-NPL4-UFD1 AAA ATPase complex and VCP-NSFL1C complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Heart (RPKM 1161.1), Muscle (RPKM 1081.6) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vcp in Genome Data Viewer
Location:
5q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (62005984..62025387, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (57210167..57229571, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (58426548..58445953, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B5 Neighboring gene SPATA31 subfamily G member 1 Neighboring gene FA complementation group G Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class O Neighboring gene stomatin like 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by RGD

Items 1 - 25 of 32
Function Evidence Code Pubs
enables ADP binding PubMed 
enables ADP binding  
enables ATP binding PubMed 
enables ATP binding PubMed 
enables ATP binding  
enables ATP hydrolysis activity  
enables ATP hydrolysis activity PubMed 
enables ATP hydrolysis activity PubMed 
enables ATP hydrolysis activity  
enables ATP-dependent H2AZ histone chaperone activity  
enables ATP-dependent H3-H4 histone complex chaperone activity  
enables BAT3 complex binding  
enables DNA clamp loader activity  
enables K48-linked polyubiquitin modification-dependent protein binding  
enables MHC class I protein binding  
enables chromatin extrusion motor activity  
enables cohesin loader activity  
enables deubiquitinase activator activity  
enables identical protein binding PubMed 
enables identical protein binding PubMed 
enables identical protein binding  
enables lipid binding  
enables polyubiquitin modification-dependent protein binding  
enables polyubiquitin modification-dependent protein binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein phosphatase binding  
enables protein-containing complex binding PubMed 
enables ubiquitin protein ligase binding  
enables ubiquitin-like protein ligase binding  
enables ubiquitin-modified protein reader activity  
enables ubiquitin-specific protease binding  
Items 1 - 25 of 32
Items 1 - 25 of 71
Process Evidence Code Pubs
involved_in ATP metabolic process  
involved_in DNA damage response  
involved_in DNA damage response  
involved_in DNA repair  
involved_in ERAD pathway PubMed 
involved_in ERAD pathway  
involved_in ERAD pathway  
involved_in NADH metabolic process  
acts_upstream_of_or_within aggresome assembly  
involved_in autophagosome maturation  
involved_in autophagosome maturation  
involved_in autophagosome maturation  
involved_in autophagy  
involved_in autophagy  
involved_in cellular response to arsenite ion  
involved_in cellular response to arsenite ion  
involved_in cellular response to heat  
involved_in cellular response to heat  
involved_in cellular response to misfolded protein  
involved_in chromatin looping  
involved_in chromatin remodeling  
involved_in cytoplasm protein quality control  
involved_in double-strand break repair  
involved_in double-strand break repair  
involved_in endoplasmic reticulum stress-induced pre-emptive quality control  
involved_in endoplasmic reticulum stress-induced pre-emptive quality control  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport PubMed 
involved_in endosome to lysosome transport via multivesicular body sorting pathway  
involved_in endosome to lysosome transport via multivesicular body sorting pathway  
involved_in flavin adenine dinucleotide catabolic process  
involved_in interstrand cross-link repair  
involved_in macroautophagy  
involved_in macroautophagy  
involved_in mitotic spindle disassembly  
involved_in negative regulation of hippo signaling  
involved_in negative regulation of protein localization to chromatin  
involved_in negative regulation of smoothened signaling pathway  
involved_in positive regulation of ATP biosynthetic process  
involved_in positive regulation of Lys63-specific deubiquitinase activity  
involved_in positive regulation of canonical Wnt signaling pathway  
involved_in positive regulation of mitochondrial membrane potential  
involved_in positive regulation of non-canonical NF-kappaB signal transduction  
involved_in positive regulation of oxidative phosphorylation  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
involved_in positive regulation of protein K63-linked deubiquitination  
involved_in positive regulation of protein catabolic process  
involved_in positive regulation of protein-containing complex assembly  
involved_in positive regulation of ubiquitin-dependent protein catabolic process PubMed 
involved_in proteasomal protein catabolic process  
involved_in proteasomal protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
involved_in protein ubiquitination  
involved_in protein ubiquitination  
involved_in protein-DNA covalent cross-linking repair  
involved_in protein-DNA covalent cross-linking repair  
involved_in regulation of aerobic respiration  
involved_in regulation of protein localization to chromatin  
involved_in regulation of protein localization to chromatin  
involved_in regulation of synapse organization PubMed 
involved_in regulation of synapse organization PubMed 
involved_in retrograde protein transport, ER to cytosol PubMed 
involved_in retrograde protein transport, ER to cytosol  
involved_in retrograde protein transport, ER to cytosol  
involved_in stress granule disassembly  
involved_in stress granule disassembly  
involved_in translesion synthesis  
involved_in translesion synthesis  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process  
involved_in viral genome replication  
Items 1 - 25 of 71
Items 1 - 20 of 32
Component Evidence Code Pubs
part_of ATPase complex  
part_of Derlin-1 retrotranslocation complex  
part_of VCP-NPL4-UFD1 AAA ATPase complex PubMed 
part_of VCP-NPL4-UFD1 AAA ATPase complex  
part_of VCP-NPL4-UFD1 AAA ATPase complex PubMed 
part_of VCP-NPL4-UFD1 AAA ATPase complex  
part_of VCP-NSFL1C complex PubMed 
part_of VCP-NSFL1C complex  
located_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasmic stress granule  
located_in cytoplasmic stress granule  
is_active_in cytosol  
located_in cytosol PubMed 
is_active_in cytosol  
located_in cytosol  
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
located_in lipid droplet  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
located_in perinuclear region of cytoplasm  
part_of proteasome complex  
part_of protein-containing complex  
located_in site of double-strand break  
located_in site of double-strand break  
is_active_in synapse  
Items 1 - 20 of 32

General protein information

Preferred Names
transitional endoplasmic reticulum ATPase
Names
15S Mg(2+)-ATPase p97 subunit
TER ATPase
NP_446316.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053864.2NP_446316.1  transitional endoplasmic reticulum ATPase

    See identical proteins and their annotated locations for NP_446316.1

    Status: PROVISIONAL

    Source sequence(s)
    BC060518
    UniProtKB/Swiss-Prot
    P46462
    UniProtKB/TrEMBL
    A6IIZ6, A6IIZ7
    Related
    ENSRNOP00000040121.2, ENSRNOT00000046102.4
    Conserved Domains (1) summary
    TIGR01243
    Location:25764
    CDC48; AAA family ATPase, CDC48 subfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    62005984..62025387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.