Tnc tenascin C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tncprovided by RGD
Official Full Name: tenascin Cprovided by RGD
Primary source: RGD:621057
See related: Ensembl:ENSRNOG00000058645 AllianceGenome:RGD:621057
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable syndecan binding activity. Involved in several processes, including animal organ morphogenesis; cellular response to lipid; and cellular response to prostaglandin D stimulus. Located in extracellular matrix. Used to study pulmonary hypertension. Biomarker of cholangiocarcinoma; high grade glioma; myocardial infarction; polycystic kidney disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; and autosomal dominant nonsyndromic deafness 56. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 401.5), Kidney (RPKM 192.6) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q24

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (82391340..82476197, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (77375851..77460712, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (79789686..79874555, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
Title: Multiparametric Evaluation of Post-MI Small Animal Models Using Metabolic ([(18)F]FDG) and Perfusion-Based (SYN1) Heart Viability Tracers.
TNC gene silencing relieved neuronal apoptosis and neuroinflammation by activating the PI3K/Akt/ NF-kappaB signaling pathway in subarachnoid hemorrhage.
Title: Silencing of Tenascin-C Inhibited Inflammation and Apoptosis Via PI3K/Akt/NF-κB Signaling Pathway in Subarachnoid Hemorrhage Cell Model.
This study aimed to investigate the role of TNC and CCN3 as prognostic factors for post hepatectomy liver failure (PHLF) in a rat model of partial hepatectomy and 50 patients following partial hepatectomy.
Title: The Predictive Role of Tenascin-C and Cellular Communication Network Factor 3 (CCN3) in Post Hepatectomy Liver Failure in a Rat Model and 50 Patients Following Partial Hepatectomy.
these results indicated that in an indirect coculture system, pelvic ligament fibroblasts with mechanical stretch stimulation may promote the synthesis of tenascinC and BMSC differentiation into pelvic ligament fibroblasts.
Title: Tenascin-C expression and its associated pathway in BMSCs following co-culture with mechanically stretched ligament fibroblasts.
Epicardium-derived cells (EPDCs) from post-myocardial infarction hearts highly expressed tenascin-C, which induces pro-IL-1beta transcription in EPDCs and thus contributes to inflammasome activation.
Title: CD73-derived adenosine and tenascin-C control cytokine production by epicardium-derived cells formed after myocardial infarction.
tenascin-C and phosphacan represent early indicators of neurodegeneration.
Title: Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model.
In a liver fibrosis cellular model, tenascin-C promotes migration of hepatic stellate cells and production of type I collagen via TGF-beta1 and alpha9beta1 integrin pathway.
Title: Tenascin-C promotes migration of hepatic stellate cells and production of type I collagen.
Co-localization of tenascin-C and fibronectin immunoreactivity was observed in many regions
Title: Immunohistochemical localization of tenascin-C in rat periodontal ligament with reference to alveolar bone remodeling.
the D/P Cr ratio was correlated with effluent levels of TN-C (rho = 0.57, p < 0.001) and MMP-2 (rho = 0.73, p < 0.001). We suggest that TN-C in the effluents may be a diagnostic marker for peritoneal deterioration with EMT-like change
Title: Effluent Tenascin-C Levels Reflect Peritoneal Deterioration in Peritoneal Dialysis: MAJOR IN PD Study.
Results show that TNC upregulation is mediated in part by activation of TGF-beta signaling pathway, which support the idea that misregulation of this signaling pathway produces changes that may contribute to disease
Title: Role of TGF-β signaling pathway on Tenascin C protein upregulation in a pilocarpine seizure model.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130033 (e-PCR)
- UniSTS:213321

Tnc (e-PCR), detects polymorphism
- UniSTS:531314

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables syndecan binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bud outgrowth involved in lung branching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to prostaglandin D stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within peripheral nervous system axon regeneration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland epithelium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fibroblast growth factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in interstitial matrix	ISO Inferred from Sequence Orthology more info
is_active_in perisynaptic extracellular matrix	ISO Inferred from Sequence Orthology more info
part_of tenascin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tenascin

Names: Tn-C AD1; tenascin-C AD1 domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053861.2 → NP_446313.2 tenascin precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A8I6AG89, B2LYI9

Related

ENSRNOP00000091808.1, ENSRNOT00000109041.1

Conserved Domains (6) summary

cd00054
Location:526 → 559

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1798 → 2007

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:207 → 537

exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

82391340..82476197 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008763754.4 → XP_008761976.1 tenascin isoform X1

UniProtKB/TrEMBL

A0A8I6ARC1, B2LYI9

Related

ENSRNOP00000096828.1

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1981 → 2190

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain
XM_008763755.4 → XP_008761977.1 tenascin isoform X2

UniProtKB/TrEMBL

B2LYI9

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1890 → 2099

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain
XM_008763756.4 → XP_008761978.1 tenascin isoform X3

UniProtKB/TrEMBL

A0A0G2K1L0, B2LYI9

Related

ENSRNOP00000071884.2

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1889 → 2098

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain
XM_039109145.1 → XP_038965073.1 tenascin isoform X4

Conserved Domains (6) summary

cd00054
Location:526 → 559

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1708 → 1917

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:207 → 537

exchanger_TraA; outer membrane exchange protein TraA
XM_063287067.1 → XP_063143137.1 tenascin isoform X5

UniProtKB/TrEMBL

A0A8I6GHT4
XM_039109146.1 → XP_038965074.1 tenascin isoform X6

UniProtKB/TrEMBL

B2LYI9

Conserved Domains (6) summary

cd00054
Location:526 → 559

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1617 → 1826

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:207 → 537

exchanger_TraA; outer membrane exchange protein TraA
XM_039109148.1 → XP_038965076.1 tenascin isoform X8

UniProtKB/TrEMBL

B2LYI9

Conserved Domains (5) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1525 → 1734

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:207 → 537

exchanger_TraA; outer membrane exchange protein TraA
XM_039109147.1 → XP_038965075.1 tenascin isoform X7

UniProtKB/TrEMBL

B2LYI9

Conserved Domains (5) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1525 → 1734

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:207 → 537

exchanger_TraA; outer membrane exchange protein TraA
XM_039109150.1 → XP_038965078.1 tenascin isoform X10

UniProtKB/TrEMBL

A0A8I6AIS3

Related

ENSRNOP00000093442.1, ENSRNOT00000107729.1

Conserved Domains (5) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam18720
Location:408 → 435

EGF_Tenascin; Tenascin EGF domain

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1343 → 1552

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

NF033759
Location:207 → 537

exchanger_TraA; outer membrane exchange protein TraA
XM_008763758.4 → XP_008761980.1 tenascin isoform X9

UniProtKB/TrEMBL

B2LYI9

Conserved Domains (4) summary

cd00063
Location:624 → 710

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:894 → 976

fn3; Fibronectin type III domain

pfam00147
Location:1434 → 1643

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam07974
Location:408 → 434

EGF_2; EGF-like domain