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Akap8 A-kinase anchoring protein 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116633, updated on 11-Apr-2024

Summary

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Official Symbol
Akap8provided by RGD
Official Full Name
A-kinase anchoring protein 8provided by RGD
Primary source
RGD:620832
See related
Ensembl:ENSRNOG00000006559 AllianceGenome:RGD:620832
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akap95
Summary
Enables double-stranded DNA binding activity; protein kinase A regulatory subunit binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of tumor necrosis factor production; and regulation of histone modification. Predicted to act upstream of or within mitotic chromosome condensation. Located in Golgi apparatus; mitochondrion; and nuclear matrix. Orthologous to human AKAP8 (A-kinase anchoring protein 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 284.2), Spleen (RPKM 266.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11966769..11983056, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11316224..11332523, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14323298..14339953, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 3 Neighboring gene bromodomain containing 4 Neighboring gene uncharacterized LOC134479823 Neighboring gene A-kinase anchoring protein 8 like Neighboring gene uncharacterized LOC134479821

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring. Faruque OM, et al. Am J Physiol Cell Physiol, 2009 Feb. PMID 19073898
  2. Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation. Asirvatham AL, et al. Cell Signal, 2021 Jul. PMID 33716104
  3. A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. Marstad A, et al. FEBS J, 2016 Feb. PMID 26683827
  4. Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability. Jungmann RA, et al. J Biol Chem, 2005 Jul 1. PMID 15878851
  5. Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105. Wall EA, et al. Sci Signal, 2009 Jun 16. PMID 19531803, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation.
    Title: Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann cell proliferation.
  2. new insights into how AKAP95 orchestrates cell cycle progression.
    Title: Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function.
  3. Used cell permeable peptide to disrupt endogenous protein kinase A R2alpha (pkar2a)-AKAP95 complexes.
    Title: Cell-permeable peptide-based disruption of endogenous PKA-AKAP complexes: a tool for studying the molecular roles of AKAP-mediated PKA subcellular anchoring.
  4. lactate dehydrogenase subunit A mRNA stability is regulated by Cyclic AMP and AKAP-mediated targeting of protein kinase A
    Title: Cyclic AMP and AKAP-mediated targeting of protein kinase A regulates lactate dehydrogenase subunit A mRNA stability.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A regulatory subunit binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle G2/M phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic chromosome condensation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in female pronucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 8
Names
A kinase (PRKA) anchor protein 8
A-kinase anchor protein 95 kDa
AKAP 95
AKAP-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053855.1 → NP_446307.1  A-kinase anchor protein 8

    See identical proteins and their annotated locations for NP_446307.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166580
    UniProtKB/Swiss-Prot
    Q63014
    UniProtKB/TrEMBL
    A0A8I6AAG3, B2GV93
    Related
    ENSRNOP00000008827.4, ENSRNOT00000008827.7
    Conserved Domains (1) summary
    pfam04988
    Location:388 → 548
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    11966769..11983056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594573.3 → XP_017450062.1  A-kinase anchor protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AAG3

  2. XM_006241047.5 → XP_006241109.1  A-kinase anchor protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAG3
    Conserved Domains (1) summary
    pfam04988
    Location:314 → 474
    AKAP95; A-kinase anchoring protein 95 (AKAP95)

  3. XM_039078250.2 → XP_038934178.1  A-kinase anchor protein 8 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63014.1 GenPept UniProtKB/Swiss-Prot:Q63014

Gene LinkOut

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