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Nat1 N-acetyltransferase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116631, updated on 11-Apr-2024

Summary

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Official Symbol
Nat1provided by RGD
Official Full Name
N-acetyltransferase 1provided by RGD
Primary source
RGD:70490
See related
Ensembl:ENSRNOG00000049498 AllianceGenome:RGD:70490
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nat
Summary
Enables arylamine N-acetyltransferase activity. Involved in aging; liver development; and response to thyroxine. Located in cytosol. Human ortholog(s) of this gene implicated in carcinoma (multiple); contact dermatitis (multiple); pancreatic cancer; and prostate cancer. Orthologous to human NAT1 (N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Expression
Biased expression in Liver (RPKM 127.8), Spleen (RPKM 82.7) and 9 other tissues See more
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Genomic context

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Location:
16p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (26984882..27005194, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (22218217..22238516, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (23970742..23991573, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene N-acetyltransferase 3 Neighboring gene high mobility group box 2, pseudogene 3 Neighboring gene N-acetyltransferase 2 Neighboring gene golgin A4, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel translational repressor (NAT-1) expression is modified by thyroid state and age in brain and liver. Shah GN, et al. Eur J Endocrinol, 1998 Dec. PMID 9916872
  2. Association of the NAT1*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokers. Abdel-Rahman SZ, et al. Mutat Res, 1998 Feb 26. PMID 9626964
  3. Combination therapy with 5-azacytidine plus beta-2'-deoxythioguanosine in adult acute leukemia. Omura GA. Cancer Treat Rep, 1977 Aug. PMID 70273
  4. Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells. Liu YJ, et al. J Pineal Res, 2012 May. PMID 22225631
  5. 4,4'-methylenedianiline-induced hepatotoxicity is modified by N-acetyltransferase 2 (NAT2) acetylator polymorphism in the rat. Zhang X, et al. J Pharmacol Exp Ther, 2006 Jan. PMID 16192314

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A higher level of melatonin was demonstrated in cultured ApoE4-C6 cells than in ApoE3-C6 cells. NAT was up-regulated in ApoE4-C6 cells compared with ApoE3-C6 cells, and MAOA and MAOB expression decreased in ApoE4-C6 cells.
    Title: Apolipoprotein E influences melatonin biosynthesis by regulating NAT and MAOA expression in C6 cells.
  2. The expressions of Clock and NAT genes in the pineal gland not only show remarkably synchronous endogenous circadian rhythmic changes, but also response to the ambient light signal in a reduced manner.
    Title: [Circadian rhythms and light responses of clock gene and arylalkylamine N-acetyltransferase gene expressions in the pineal gland of rats].
  3. Results demonstrate differential tissue-specific and developmental regulation of the rat Nat1 and Nat2 genes.
    Title: Quantitative tissue and gene-specific differences and developmental changes in Nat1, Nat2, and Nat3 mRNA expression in the rat.
  4. RT-PCR experiments demonstrated that the relative expression of the rNat transcripts in liver and 12 extrahepatic tissues was rNat1 > rNat2, while rNat3 transcripts were not detected.
    Title: Tissue expression and genomic sequences of rat N-acetyltransferases rNat1, rNat2, rNat3, and Functional characterization of a novel rNat3*2 genetic variant.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables arylamine N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylamine N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arylamine N-acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to thyroxine IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arylamine N-acetyltransferase 1
Names
AT-1
N-acetyltransferase (arylamine N-acetyltransferase)
N-acetyltransferase 1 (arylamine N-acetyltransferase)
N-acetyltransferase type 1
NAT-1
arylamide acetylase 1
NP_001032392.1
NP_001032393.1
NP_446305.1
XP_006253063.1
XP_006253064.1
XP_006253066.1
XP_017455466.1
XP_017455467.1
XP_038950079.1
XP_038950080.1
XP_038950081.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037315.1 → NP_001032392.1  arylamine N-acetyltransferase 1

    See identical proteins and their annotated locations for NP_001032392.1

    Status: VALIDATED

    Source sequence(s)
    BC078765, U01343
    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Related
    ENSRNOP00000018854.3, ENSRNOT00000018854.7
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  2. NM_001037316.2 → NP_001032393.1  arylamine N-acetyltransferase 1

    See identical proteins and their annotated locations for NP_001032393.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  3. NM_053853.2 → NP_446305.1  arylamine N-acetyltransferase 1

    See identical proteins and their annotated locations for NP_446305.1

    Status: VALIDATED

    Source sequence(s)
    BC078765, CB580886
    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    26984882..27005194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253001.4 → XP_006253063.1  arylamine N-acetyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006253063.1

    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Related
    ENSRNOP00000070053.1
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  2. XM_006253002.5 → XP_006253064.1  arylamine N-acetyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006253064.1

    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  3. XM_039094153.2 → XP_038950081.1  arylamine N-acetyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  4. XM_039094151.2 → XP_038950079.1  arylamine N-acetyltransferase 1 isoform X3

    Conserved Domains (1) summary
    pfam00797
    Location:23 → 283
    Acetyltransf_2; N-acetyltransferase

  5. XM_017599977.3 → XP_017455466.1  arylamine N-acetyltransferase 1 isoform X1

  6. XM_039094152.2 → XP_038950080.1  arylamine N-acetyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  7. XM_006253004.5 → XP_006253066.1  arylamine N-acetyltransferase 1 isoform X2

    See identical proteins and their annotated locations for XP_006253066.1

    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase

  8. XM_017599978.3 → XP_017455467.1  arylamine N-acetyltransferase 1 isoform X2

    UniProtKB/Swiss-Prot
    P50297
    UniProtKB/TrEMBL
    Q45G61, Q45G71
    Related
    ENSRNOP00000086645.1
    Conserved Domains (1) summary
    pfam00797
    Location:20 → 280
    Acetyltransf_2; N-acetyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50297.1 GenPept UniProtKB/Swiss-Prot:P50297

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