Serpinb5 serpin family B member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinb5provided by RGD
Official Full Name: serpin family B member 5provided by RGD
Primary source: RGD:69342
See related: Ensembl:ENSRNOG00000002640 AllianceGenome:RGD:69342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pi5; PI-5; Maspin
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human SERPINB5 (serpin family B member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 84.1), Lung (RPKM 25.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (23500203..23520401)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (22985557..23005756)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (26903052..26923250)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype.
Title: Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype.
The potential function of IKKalpha in gastric precancerous lesion via mediating Maspin.
Title: The potential function of IKKα in gastric precancerous lesion via mediating Maspin.
During rat tooth development, maspin expression was observed for the first time in inner and outer enamel epithelial cells and dental papilla cells at early bell stage.
Title: Possible involvement of maspin in tooth development.
Results show that VACM-1 protein regulates endothelial cell growth and may modulate angiogenesis by a mechanism that involves MAPK phosphorylation and maspin expression.
Title: Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotype.
maspin expressed in active osteoblasts plays an important physiological role during maturation of the bone matrix, and in particular, during the process of accumulation of latent TGF-beta in the extracellular matrix
Title: Maspin is involved in bone matrix maturation by enhancing the accumulation of latent TGF-beta.

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General gene information

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Markers

D13Rat60 (e-PCR), detects polymorphism
- UniSTS:226578

RH134638 (e-PCR)
- UniSTS:217917

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serpin B5

Names: peptidase inhibitor 5; protease inhibitor 5; serine (or cysteine) peptidase inhibitor, clade B, member 5; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; serpin peptidase inhibitor, clade B (ovalbumin), member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057108.3 → NP_476449.2 serpin B5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P70564

UniProtKB/TrEMBL

A6JSV3, G3V6C1

Related

ENSRNOP00000003625.6, ENSRNOT00000003625.8

Conserved Domains (1) summary

cd02057
Location:1 → 375

serpinB5_maspin; serpin family B member 5, mammary serine proteinase inhibitor