Ggt1 gamma-glutamyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ggt1provided by RGD
Official Full Name: gamma-glutamyltransferase 1provided by RGD
Primary source: RGD:2683
See related: Ensembl:ENSRNOG00000047697 AllianceGenome:RGD:2683
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ggt; Ggtp; GGLUT
Summary: Enables aminoacyltransferase activity. Involved in several processes, including liver development; peptide modification; and response to estradiol. Located in extracellular space. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1821.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (13074141..13103551, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (13074695..13104095, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (14019723..14045781, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

an extensive ductular reaction in advanced Hepatocellular carcinoma (HCC) and a strong correlation between PCK7 and levels of gammaGT and the poor prognosis and aggressiveness of HCC, is reported.
Title: Ductular reaction, cytokeratin 7 positivity, and gamma-glutamyl transferase in multistage hepatocarcinogenesis in rats.
These data demonstrate the important role of endothelial GGT activity in mediating the vasorelaxant effect of S-nitrosoglutathione in rat aorta .
Title: Endothelial γ-glutamyltransferase contributes to the vasorelaxant effect of S-nitrosoglutathione in rat aorta.
Data suggest that extracellular glutathione elicits gamma-glutamyl transpeptidase and ROS-dependent transactivation of tyrosine kinase signaling that upregulates potassium channel activity or expression via redox-mediated mechanisms.
Title: Role of gamma-glutamyl transpeptidase in redox regulation of K+ channel remodeling in postmyocardial infarction rat hearts.
The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress
Title: The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress.
Radiation of CC531 colon carcinoma cells blocked cell proliferation, increased cellular size, initiated apoptosis and upregulated GGT activity and protein levels in a dose- and time-related manner.
Title: Radiation-induced upregulation of gamma-glutamyltransferase in colon carcinoma cells is mediated through the Ras signal transduction pathway.
With the co-existence of inflammation and hypoxia in the brain after ischemic stroke, dynamic changes of gammaGT activity reflect evolving changes of endothelial function.
Title: Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke.
Although ALT and GMT activities and TNF-alpha and IL-6 concentrations were higher in male rats histopathological findings have shown slightly more advanced fibrotic and inflammatory changes in female rats.
Title: The differences in selected biochemical markers and histological findings after bile duct ligation in male and female rats.
The acylation reaction of GGT by gamma-glutamyl anilides can apparently be accelerated by either electron-withdrawing or electron-donating substituents, suggesting a concerted mechanism involving kinetic general acid catalysis of aniline departure.
Title: Nonlinear free energy relationship in the general-acid-catalyzed acylation of rat kidney gamma-glutamyl transpeptidase by a series of gamma-glutamyl anilide substrate analogues.

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General gene information

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Markers

338D4-Sp6 (e-PCR), detects polymorphism
- UniSTS:140934

d20arb4 (e-PCR)
- UniSTS:121524

D20Arb3 (e-PCR), detects polymorphism
- UniSTS:227285

D20Wox9 (e-PCR)
- UniSTS:518875

Ggt1 (e-PCR), detects polymorphism
- UniSTS:265710

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminoacyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione hydrolase activity	IEA Inferred from Electronic Annotation more info
enables glutathione hydrolase activity	ISO Inferred from Sequence Orthology more info
enables glutathione hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables leukotriene C4 gamma-glutamyl transferase activity	IEA Inferred from Electronic Annotation more info
enables leukotriene-C(4) hydrolase	ISO Inferred from Sequence Orthology more info
enables peptidyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in cysteine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cysteine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutamate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glutathione catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in hepatoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in hepatocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in leukotriene D4 biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in leukotriene metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in peptide modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide modification	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune system process	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune system process	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info
involved_in zymogen activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	IEA Inferred from Electronic Annotation more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione hydrolase 1 proenzyme

Names: GGT 1; gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase; gamma-glutamyltranspeptidase 1; leukotriene-C4 hydrolase

NP_446292.2

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_038954310.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_038954311.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_038954312.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_038954313.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_063135001.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_063135002.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_063135003.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_063135004.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

XP_063135005.1

EC 2.3.2.2

EC 3.4.19.13

EC 3.4.19.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053840.2 → NP_446292.2 glutathione hydrolase 1 proenzyme

See identical proteins and their annotated locations for NP_446292.2

Status: PROVISIONAL

Source sequence(s)

BC078768

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32

UniProtKB/TrEMBL

A6JKJ2

Related

ENSRNOP00000065923.3, ENSRNOT00000074533.3

Conserved Domains (1) summary

pfam01019
Location:55 → 563

G_glu_transpept; Gamma-glutamyltranspeptidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

13074141..13103551 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098385.2 → XP_038954313.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32

UniProtKB/TrEMBL

A6JKJ2

Conserved Domains (1) summary

pfam01019
Location:55 → 563

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_063278933.1 → XP_063135003.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32
XM_039098383.2 → XP_038954311.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32

UniProtKB/TrEMBL

A6JKJ2

Conserved Domains (1) summary

pfam01019
Location:55 → 563

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_063278931.1 → XP_063135001.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32
XM_063278934.1 → XP_063135004.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32
XM_063278932.1 → XP_063135002.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32
XM_063278935.1 → XP_063135005.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32
XM_039098382.2 → XP_038954310.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32

UniProtKB/TrEMBL

A6JKJ2

Conserved Domains (1) summary

pfam01019
Location:55 → 563

G_glu_transpept; Gamma-glutamyltranspeptidase
XM_039098384.2 → XP_038954312.1 glutathione hydrolase 1 proenzyme isoform X1

UniProtKB/Swiss-Prot

P07314, Q63217, Q63218, Q6AZ32

UniProtKB/TrEMBL

A6JKJ2

Conserved Domains (1) summary

pfam01019
Location:55 → 563

G_glu_transpept; Gamma-glutamyltranspeptidase