Calcr calcitonin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Calcrprovided by RGD
Official Full Name: calcitonin receptorprovided by RGD
Primary source: RGD:621001
See related: Ensembl:ENSRNOG00000010053 AllianceGenome:RGD:621001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcitonin binding activity and calcitonin receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 27.7), Brain (RPKM 15.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q13

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (32615955..32691075, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (31661270..31736392, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (28627439..28702559, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In conclusion, oral KBP-042 is a novel DACRA, which exerts antiobesity and antidiabetic efficacy by dual modulation of insulin sensitivity and directly decelerating stress on the pancreatic alpha- and beta-cells.
Title: A novel oral dual amylin and calcitonin receptor agonist (KBP-042) exerts antiobesity and antidiabetic effects in rats.
Calcitonin receptor mRNA expression declines with age on osteocytes.
Title: Decline in calcitonin receptor expression in osteocytes with age.
variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent Herpes simplex encephalitis development.
Title: The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
RAMP interaction with the CTRa in COS-7 or HEK-293 cells leads to selective modulation of signaling pathways activated by the receptor complex.
Title: Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors.
calcitonin receptor C1a protein expression has been identified in the ureteric ducts in the metanephros and both isoforms expressed in the distal portions of the developing nephrons and collecting ducts
Title: Calcitonin receptor isoforms expressed in the developing rat kidney.
Abundant expression of calcitonin C1 receptors was found in the nucleus accumbens, lateral arcuate nucleus, lateral substantia nigra, bed nucleus, locus coeruleus, area postrema, nucleus of the solitary tract, and some nuclei of the reticular formation.
Title: Immunohistochemical mapping of calcitonin receptors in the adult rat brain.
By using in situ hybridization, the codistribution of CT((a))/CT((b)) with RAMP1-3 and c-fos was mapped in CVOs of rats.
Title: Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat.
These studies indicate a role for CTR in the activation of some premigratory neuroblasts in the CNS.
Title: Ontogeny of calcitonin receptor mRNA and protein in the developing central nervous system of the rat.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Calcr (e-PCR), detects polymorphism
- UniSTS:265567

Calcr (e-PCR), detects polymorphism
- UniSTS:141216

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables amylin receptor activity	IEA Inferred from Electronic Annotation more info
enables amylin receptor activity	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IEA Inferred from Electronic Annotation more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables calcitonin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcitonin binding	IEA Inferred from Electronic Annotation more info
NOT enables calcitonin binding	ISO Inferred from Sequence Orthology more info
enables calcitonin binding	ISO Inferred from Sequence Orthology more info
enables calcitonin gene-related peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin gene-related peptide receptor activity	ISO Inferred from Sequence Orthology more info
enables calcitonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcitonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables calcitonin receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in amylin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in amylin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in mononuclear cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
acts_upstream_of ossification	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mRNA stability	ISO Inferred from Sequence Orthology more info
involved_in response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotation more info
involved_in response to glucocorticoid	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
part_of amylin receptor complex 1	IEA Inferred from Electronic Annotation more info
part_of amylin receptor complex 1	ISO Inferred from Sequence Orthology more info
part_of amylin receptor complex 2	IEA Inferred from Electronic Annotation more info
part_of amylin receptor complex 2	ISO Inferred from Sequence Orthology more info
part_of amylin receptor complex 3	IEA Inferred from Electronic Annotation more info
part_of amylin receptor complex 3	ISO Inferred from Sequence Orthology more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: calcitonin receptor

Names: C1A/C1B; CT-R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034015.1 → NP_001029187.1 calcitonin receptor isoform 1a precursor

See identical proteins and their annotated locations for NP_001029187.1

Status: VALIDATED

Description

Transcript Variant: This variant (1a, previously called 2), lacks an alternate in-frame exon compared to variant 1b. The resulting isoform (1a, previously called b), has the same N- and C-termini but is shorter compared to isoform 1b.

Source sequence(s)

CB791100, L14617

UniProtKB/TrEMBL

A0A0H2UHI3, A6K2A3, A6K2A6

Related

ENSRNOP00000013937.6, ENSRNOT00000013937.6

Conserved Domains (2) summary

pfam00002
Location:162 → 404

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:86 → 154

HRM; Hormone receptor domain
NM_053816.2 → NP_446268.2 calcitonin receptor isoform 1b precursor

See identical proteins and their annotated locations for NP_446268.2

Status: VALIDATED

Description

Transcript Variant: This variant (1b), previously called 1, represents the longer variant and encodes the longer isoform (1b, previously called a).

Source sequence(s)

CB791100, L14617, L14618

UniProtKB/Swiss-Prot

P32213, P32214

UniProtKB/TrEMBL

A0A0H2UHI1, A6K2A4, A6K2A7

Related

ENSRNOP00000013910.6, ENSRNOT00000013910.8

Conserved Domains (2) summary

pfam00002
Location:162 → 441

7tm_2; 7 transmembrane receptor (Secretin family)

pfam02793
Location:86 → 154

HRM; Hormone receptor domain