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Akap4 A kinase anchor protein 4 [ Mus musculus (house mouse) ]

Gene ID: 11643, updated on 11-Apr-2024

Summary

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Official Symbol
Akap4provided by MGI
Official Full Name
A kinase anchor protein 4provided by MGI
Primary source
MGI:MGI:102794
See related
Ensembl:ENSMUSG00000050089 AllianceGenome:MGI:102794
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p82; Fsc1; PRKA4; AKAP-4; AKAP82; mAKAP82
Summary
Enables protein kinase A binding activity. Involved in flagellated sperm motility. Acts upstream of or within establishment of protein localization; motile cilium assembly; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in Z disc; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human AKAP4 (A-kinase anchoring protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 214.6) See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.17 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (6933754..6944848)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7067515..7078609)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase kappa Neighboring gene cyclin B3 Neighboring gene STARR-seq mESC enhancer starr_46659 Neighboring gene STARR-seq mESC enhancer starr_46660 Neighboring gene ribosomal protein L23a pseudogene Neighboring gene chloride channel, voltage-sensitive 5 Neighboring gene predicted gene, 26401

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS. Choowong-In P, et al. Andrologia, 2021 Apr. PMID 33486757
  2. Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis. Fang X, et al. Dev Biol, 2019 Oct 15. PMID 31255637
  3. Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4. Mirandola L, et al. BMC Cancer, 2011 Sep 16. PMID 21923911, Free PMC Article
  4. Protein domains govern the intracellular distribution of mouse sperm AKAP4. Nipper RW, et al. Biol Reprod, 2006 Aug. PMID 16687648
  5. Characterization of Fsc1 cDNA for a mouse sperm fibrous sheath component. Fulcher KD, et al. Biol Reprod, 1995 Jan. PMID 7711182

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4.
    Title: Identification of CD8(+) T-cell epitope from multiple myeloma-specific antigen AKAP4.
  2. Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
    Title: Loss-of-function missense variant of AKAP4 induced male infertility through reduced interaction with QRICH2 during sperm flagella development.
  3. Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS.
    Title: Decreased expression of AKAP4 and TyrPho proteins in testis, epididymis, and spermatozoa with low sexual performance of mice induced by modified CUMS.
  4. Phosphoproteomics and Bioinformatics Analyses Reveal Key Roles of GSK-3 and AKAP4 in Mouse Sperm Capacitation.
    Title: Phosphoproteomics and Bioinformatics Analyses Reveal Key Roles of GSK-3 and AKAP4 in Mouse Sperm Capacitation.
  5. we validated the use of AKAP-4 antigen to track tumor growth in vivo and to specifically identify MM cells in mouse tissues.
    Title: Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4.
  6. AKAP4 has a major role in completing fibrous sheath assembly
    Title: A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum.
  7. Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.
    Title: Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility.
  8. the distribution of AKAP4 was dependent on the microtubular cytoskeleton.
    Title: Protein domains govern the intracellular distribution of mouse sperm AKAP4.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm connecting piece ISO
Inferred from Sequence Orthology
more info
  
located_in sperm end piece ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 4
Names
A kinase (PRKA) anchor protein 4
A kinase anchoring protein 4
A-kinase anchor protein 82 kDa
major sperm fibrous sheath protein
protein kinase A-anchoring protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042542.2 → NP_001036007.1  A-kinase anchor protein 4 isoform b

    See identical proteins and their annotated locations for NP_001036007.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AL808124
    Consensus CDS
    CCDS40839.1
    UniProtKB/TrEMBL
    Q9Z263
    Related
    ENSMUSP00000111417.2, ENSMUST00000115751.3
    Conserved Domains (1) summary
    cl14906
    Location:5 → 840
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

  2. NM_009651.4 → NP_033781.2  A-kinase anchor protein 4 isoform a

    See identical proteins and their annotated locations for NP_033781.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL808124, BC130271
    Consensus CDS
    CCDS40838.1
    UniProtKB/Swiss-Prot
    B1AXM7, Q60630, Q60662, Q8R2G7
    UniProtKB/TrEMBL
    A1L3T6, Q9Z263
    Related
    ENSMUSP00000050962.7, ENSMUST00000057101.13
    Conserved Domains (1) summary
    cl14906
    Location:14 → 849
    AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    6933754..6944848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60662.1 GenPept UniProtKB/Swiss-Prot:Q60662

Gene LinkOut

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