U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Agrp agouti related neuropeptide [ Mus musculus (house mouse) ]

Gene ID: 11604, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Agrpprovided by MGI
Official Full Name
agouti related neuropeptideprovided by MGI
Primary source
MGI:MGI:892013
See related
Ensembl:ENSMUSG00000005705 AllianceGenome:MGI:892013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Art; Agrt
Summary
This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in testis adult (RPKM 3.2), placenta adult (RPKM 1.5) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8 D3; 8 53.04 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106293327..106306477, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105566695..105579845, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene ATPase, H+ transporting, lysosomal V0 subunit D1 Neighboring gene STARR-positive B cell enhancer ABC_E10519 Neighboring gene STARR-positive B cell enhancer ABC_E11395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108090885-108090994 Neighboring gene predicted gene, 38250 Neighboring gene predicted gene 45855 Neighboring gene RHO family interacting cell polarization regulator 1 Neighboring gene microRNA 1966

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice. Decourt C, et al. J Neuroendocrinol, 2022 Oct. PMID 36306199, Free PMC Article
  2. Rescue of obesity-induced infertility in female mice by silencing AgRP neurons. Bai X, et al. Biochem Biophys Res Commun, 2022 Oct 1. PMID 35870259
  3. NPY derived from AGRP neurons controls feeding via Y1 and energy expenditure and food foraging behaviour via Y2 signalling. Qi Y, et al. Mol Metab, 2022 May. PMID 35167990, Free PMC Article
  4. Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum. Reichenbach A, et al. Elife, 2022 Jan 12. PMID 35018884, Free PMC Article
  5. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Han Y, et al. Nat Commun, 2021 Jun 10. PMID 34112797, Free PMC Article

See all (308) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.
    Title: microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.
  2. Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.
    Title: Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.
  3. AgRP neurons encode circadian feeding time.
    Title: AgRP neurons encode circadian feeding time.
  4. Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
    Title: Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
  5. AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.
    Title: AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.
  6. Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
    Title: Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
  7. Bridging Energy Need and Feeding Behavior: The Impact of eIF2alpha Phosphorylation in AgRP Neurons.
    Title: Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons.
  8. AgRP neurons coordinate the mitigation of activity-based anorexia.
    Title: AgRP neurons coordinate the mitigation of activity-based anorexia.
  9. Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice.
    Title: Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice.
  10. Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.
    Title: Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo.
Submit: New GeneRIF Correction See all GeneRIFs (102)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: Gm5914

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables type 1 melanocortin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adult feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adult feeding behavior IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in hormone-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi lumen ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
agouti-related protein
Names
orexigenic neuropeptide

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271806.1 → NP_001258735.1  agouti-related protein precursor

    See identical proteins and their annotated locations for NP_001258735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC151573, AK138796, BC079902
    Consensus CDS
    CCDS22605.1
    UniProtKB/Swiss-Prot
    O35967, P56473
    UniProtKB/TrEMBL
    A0A0A6YX09, Q3UU47
    Related
    ENSMUSP00000141783.2, ENSMUST00000194654.2
    Conserved Domains (1) summary
    smart00792
    Location:1 → 121
    Agouti; Agouti protein

  2. NM_007427.3 → NP_031453.1  agouti-related protein precursor

    See identical proteins and their annotated locations for NP_031453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK138796, BC079902, CO044337
    Consensus CDS
    CCDS22605.1
    UniProtKB/Swiss-Prot
    O35967, P56473
    UniProtKB/TrEMBL
    A0A0A6YX09, Q3UU47
    Related
    ENSMUSP00000005849.6, ENSMUST00000005849.11
    Conserved Domains (1) summary
    smart00792
    Location:1 → 121
    Agouti; Agouti protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106293327..106306477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56473.1 GenPept UniProtKB/Swiss-Prot:P56473

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous