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Usp2 ubiquitin specific peptidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 115771, updated on 30-Mar-2024

Summary

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Official Symbol
Usp2provided by RGD
Official Full Name
ubiquitin specific peptidase 2provided by RGD
Primary source
RGD:621073
See related
Ensembl:ENSRNOG00000006663 AllianceGenome:RGD:621073
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
UBP-t
Summary
Enables thiol-dependent deubiquitinase. Involved in negative regulation of skeletal muscle tissue development; positive regulation of skeletal muscle tissue development; and protein deubiquitination. Located in centrosome; nucleus; and perinuclear region of cytoplasm. Orthologous to human USP2 (ubiquitin specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 196.5), Muscle (RPKM 120.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53308264..53336800)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44411457..44439668)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48403985..48432525)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480042 Neighboring gene Thy-1 cell surface antigen Neighboring gene membrane frizzled-related protein Neighboring gene C1q and TNF related 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area. Li C, et al. Neuropharmacology, 2018 Jun. PMID 29501527
  2. Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69. Park KC, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12107281, Free PMC Article
  3. Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation. Kitamura H, et al. FASEB J, 2013 Dec. PMID 24005904
  4. Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures. Lin H, et al. Mol Cell Biol, 2000 Sep. PMID 10938131, Free PMC Article
  5. Suppression of cancer cell growth by promoting cyclin D1 degradation. Shan J, et al. Mol Cell, 2009 Nov 13. PMID 19917254, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin-specific protease 2 regulates Ang -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro.
    Title: Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.
  2. results have identified USP2 as a key molecule that mediates stress-induced spatial memory retrieval impairment.
    Title: Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area.
  3. myogenic differentiation of embryonic muscle cells is antagonistically regulated by two deubiquitinating enzymes, UBP45 and UBP69, that are generated by alternative splicing[Usp2].
    Title: Antagonistic regulation of myogenesis by two deubiquitinating enzymes, UBP45 and UBP69.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC93284

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in circadian behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian behavior ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in entrainment of circadian clock by photoperiod ISO
Inferred from Sequence Orthology
more info
  
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in locomotor rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 2
Names
41 kDa ubiquitin-specific protease
deubiquitinating enzyme 2
ubiquitin specific protease 2
ubiquitin thioesterase 2
ubiquitin thiolesterase 2
ubiquitin-specific-processing protease 2
ubiquitin-specific-processing protease testis
NP_446226.3
XP_006242925.1
XP_008764360.1
XP_008764361.1
XP_038936630.1
XP_038936631.1
XP_038936632.1
XP_063120846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053774.3 → NP_446226.3  ubiquitin carboxyl-terminal hydrolase 2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
    UniProtKB/TrEMBL
    A0A8L2Q4I7
    Related
    ENSRNOP00000078529.1, ENSRNOT00000104911.1
    Conserved Domains (1) summary
    pfam00443
    Location:280 → 609
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53308264..53336800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766138.4 → XP_008764360.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X3

    Conserved Domains (2) summary
    cd02674
    Location:25 → 354
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:23 → 353
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_039080702.2 → XP_038936630.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
    UniProtKB/TrEMBL
    A0A8L2Q4I7
    Conserved Domains (1) summary
    pfam00443
    Location:280 → 609
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_039080703.2 → XP_038936631.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
    UniProtKB/TrEMBL
    A0A8L2Q4I7
    Conserved Domains (1) summary
    pfam00443
    Location:280 → 609
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. XM_039080704.2 → XP_038936632.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q5U349, Q9QXL3, Q9QXL4, Q9R083, Q9R084
    UniProtKB/TrEMBL
    A0A8L2Q4I7
    Conserved Domains (1) summary
    pfam00443
    Location:280 → 609
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. XM_006242863.5 → XP_006242925.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X2

    See identical proteins and their annotated locations for XP_006242925.1

    UniProtKB/Swiss-Prot
    Q5U349
    Related
    ENSRNOP00000030257.4
    Conserved Domains (2) summary
    cd02674
    Location:59 → 388
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:57 → 387
    UCH; Ubiquitin carboxyl-terminal hydrolase

  6. XM_008766139.3 → XP_008764361.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X4

    Conserved Domains (2) summary
    cd02674
    Location:17 → 346
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:15 → 345
    UCH; Ubiquitin carboxyl-terminal hydrolase

  7. XM_063264776.1 → XP_063120846.1  ubiquitin carboxyl-terminal hydrolase 2 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U349.1 GenPept UniProtKB/Swiss-Prot:Q5U349

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