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Adrb3 adrenergic receptor, beta 3 [ Mus musculus (house mouse) ]

Gene ID: 11556, updated on 2-May-2024

Summary

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Official Symbol
Adrb3provided by MGI
Official Full Name
adrenergic receptor, beta 3provided by MGI
Primary source
MGI:MGI:87939
See related
Ensembl:ENSMUSG00000031489 AllianceGenome:MGI:87939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adrb-3; beta 3-AR
Summary
Enables beta-3 adrenergic receptor binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure. Located in membrane. Is expressed in central nervous system; early conceptus; oocyte; and retina. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); dilated cardiomyopathy 1H; obesity; and type 2 diabetes mellitus. Orthologous to human ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 215.3), subcutaneous fat pad adult (RPKM 163.4) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A2; 8 15.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (27715804..27720833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (27225776..27230845, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933416M07 gene Neighboring gene RAB11 family interacting protein 1 (class I) Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene STARR-seq mESC enhancer starr_21022 Neighboring gene STARR-seq mESC enhancer starr_21024 Neighboring gene predicted gene 45470 Neighboring gene STARR-seq mESC enhancer starr_21025 Neighboring gene eukaryotic translation initiation factor 4E binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression. Byun S, et al. Proc Natl Acad Sci U S A, 2022 Jun 28. PMID 35737830, Free PMC Article
  2. β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity. Valentine JM, et al. J Clin Invest, 2022 Jan 18. PMID 34847077, Free PMC Article
  3. Depletion of β3-adrenergic receptor relieves pressure overload-induced cardiac hypertrophy and heart failure via enhancing innate immune response. Wei X, et al. Biomed Pharmacother, 2021 Nov. PMID 34563949
  4. D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism. Jeon HJ, et al. Cells, 2021 Mar 31. PMID 33807329, Free PMC Article
  5. β3-Adrenoreceptor Blockade Induces Stem Cells Differentiation in Melanoma Microenvironment. Calvani M, et al. Int J Mol Sci, 2020 Feb 20. PMID 32093135, Free PMC Article

See all (185) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. beta3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
    Title: β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure.
  2. Brown Adipocyte ADRB3 Mediates Cardioprotection via Suppressing Exosomal iNOS.
    Title: Brown Adipocyte ADRB3 Mediates Cardioprotection via Suppressing Exosomal iNOS.
  3. Loss of adipose TET proteins enhances beta-adrenergic responses and protects against obesity by epigenetic regulation of beta3-AR expression.
    Title: Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.
  4. HIF-1-Dependent Induction of beta3 Adrenoceptor: Evidence from the Mouse Retina.
    Title: HIF-1-Dependent Induction of β3 Adrenoceptor: Evidence from the Mouse Retina.
  5. ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
    Title: ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.
  6. beta3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity.
    Title: β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity.
  7. Depletion of beta3-adrenergic receptor relieves pressure overload-induced cardiac hypertrophy and heart failure via enhancing innate immune response.
    Title: Depletion of β3-adrenergic receptor relieves pressure overload-induced cardiac hypertrophy and heart failure via enhancing innate immune response.
  8. Impact of thermogenesis induced by chronic beta3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
    Title: Impact of thermogenesis induced by chronic β3-adrenergic receptor agonist treatment on inflammatory and infectious response during bacteremia in mice.
  9. Oxytocin and 'social hyperthermia': Interaction with beta3-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice.
    Title: Oxytocin and 'social hyperthermia': Interaction with β(3)-adrenergic receptor-mediated thermogenesis and significance for the expression of social behavior in male and female mice.
  10. D-Mannitol Induces a Brown Fat-like Phenotype via a beta3-Adrenergic Receptor-Dependent Mechanism.
    Title: D-Mannitol Induces a Brown Fat-like Phenotype via a β3-Adrenergic Receptor-Dependent Mechanism.
Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables adrenergic receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-3 adrenergic receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables beta3-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta3-adrenergic receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables epinephrine binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to norepinephrine binding ISO
Inferred from Sequence Orthology
more info
  
enables norepinephrine binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brown fat cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within diet induced thermogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heat generation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-3 adrenergic receptor
Names
Beta-3 AR
beta-3 adrenoceptor
beta-3 adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013462.3 → NP_038490.2  beta-3 adrenergic receptor

    See identical proteins and their annotated locations for NP_038490.2

    Status: VALIDATED

    Source sequence(s)
    AC102544
    Consensus CDS
    CCDS22213.1
    UniProtKB/Swiss-Prot
    A2RS74, P25962, Q9QZ98
    UniProtKB/TrEMBL
    Q3UP63
    Related
    ENSMUSP00000080162.4, ENSMUST00000081438.10
    Conserved Domains (2) summary
    cd14964
    Location:70 → 92
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:48 → 353
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    27715804..27720833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243246.2 → XP_030099106.1  beta-3 adrenergic receptor isoform X1

    UniProtKB/Swiss-Prot
    A2RS74, P25962, Q9QZ98
    UniProtKB/TrEMBL
    Q3UP63
    Conserved Domains (2) summary
    cd14964
    Location:70 → 92
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:48 → 353
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_030243247.2 → XP_030099107.1  beta-3 adrenergic receptor isoform X1

    UniProtKB/Swiss-Prot
    A2RS74, P25962, Q9QZ98
    UniProtKB/TrEMBL
    Q3UP63
    Related
    ENSMUSP00000113006.2, ENSMUST00000121838.2
    Conserved Domains (2) summary
    cd14964
    Location:70 → 92
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:48 → 353
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_004934751.1 RNA Sequence

  2. XR_004934750.1 RNA Sequence

  3. XR_003947220.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25962.2 GenPept UniProtKB/Swiss-Prot:P25962

Gene LinkOut

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