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Adora3 adenosine A3 receptor [ Mus musculus (house mouse) ]

Gene ID: 11542, updated on 14-Jan-2025

Summary

Official Symbol
Adora3provided by MGI
Official Full Name
adenosine A3 receptorprovided by MGI
Primary source
MGI:MGI:104847
See related
Ensembl:ENSMUSG00000000562 AllianceGenome:MGI:104847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A3R; A3AR; AA3R; ARA3; Gpcr2
Summary
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. This gene shares its 3' terminal exon with a transcript variant from overlapping GeneID:69296, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
Expression
Biased expression in testis adult (RPKM 3.8), mammary gland adult (RPKM 1.0) and 14 other tissues See more
Orthologs
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Genomic context

See Adora3 in Genome Data Viewer
Location:
3 F2.2; 3 46.45 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (105811737..105816244)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (105904421..105908928)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RAS-related protein 1a Neighboring gene STARR-positive B cell enhancer ABC_E10203 Neighboring gene STARR-positive B cell enhancer ABC_E11208 Neighboring gene STARR-seq mESC enhancer starr_08637 Neighboring gene predicted gene 5547 Neighboring gene STARR-seq mESC enhancer starr_08638 Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_08639 Neighboring gene STARR-positive B cell enhancer ABC_E9566 Neighboring gene STARR-positive B cell enhancer ABC_E9567 Neighboring gene RIKEN cDNA I830077J02 gene Neighboring gene STARR-seq mESC enhancer starr_08641 Neighboring gene ATP synthase peripheral stalk-membrane subunit b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

Pathways from PubChem

General gene information

Clone Names

  • MGC118217

Gene Ontology Provided by MGI

Items 1 - 25 of 28
Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway  
acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
acts_upstream_of calcium-mediated signaling PubMed 
acts_upstream_of calcium-mediated signaling PubMed 
acts_upstream_of_or_within histamine secretion by mast cell PubMed 
acts_upstream_of_or_within histamine secretion by mast cell PubMed 
acts_upstream_of mast cell degranulation PubMed 
acts_upstream_of mast cell degranulation PubMed 
acts_upstream_of mucus secretion PubMed 
acts_upstream_of mucus secretion PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity  
involved_in negative regulation of cell migration  
involved_in negative regulation of cell population proliferation  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling PubMed 
acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
acts_upstream_of_or_within positive regulation of inflammatory response PubMed 
acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
acts_upstream_of_or_within positive regulation of leukocyte migration PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation PubMed 
acts_upstream_of_or_within positive regulation of mast cell degranulation PubMed 
acts_upstream_of_or_within positive regulation of mucus secretion PubMed 
acts_upstream_of_or_within positive regulation of mucus secretion PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
involved_in presynaptic modulation of chemical synaptic transmission  
involved_in regulation of norepinephrine secretion  
Items 1 - 25 of 28
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse  
is_active_in dendrite  
is_active_in neuromuscular junction PubMed 
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in presynaptic membrane  
is_active_in synapse  
is_active_in synapse PubMed 

General protein information

Preferred Names
adenosine receptor A3
Names
G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009631.4NP_033761.2  adenosine receptor A3

    See identical proteins and their annotated locations for NP_033761.2

    Status: VALIDATED

    Source sequence(s)
    AC121847, AK013534, BY585192
    Consensus CDS
    CCDS17712.1
    UniProtKB/Swiss-Prot
    Q61618, Q9R202
    UniProtKB/TrEMBL
    Q3U4C5
    Related
    ENSMUSP00000000574.2, ENSMUST00000000574.3
    Conserved Domains (2) summary
    pfam00001
    Location:30283
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:22128
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    105811737..105816244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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