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Adcy9 adenylate cyclase 9 [ Mus musculus (house mouse) ]

Gene ID: 11515, updated on 11-Apr-2024

Summary

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Official Symbol
Adcy9provided by MGI
Official Full Name
adenylate cyclase 9provided by MGI
Primary source
MGI:MGI:108450
See related
Ensembl:ENSMUSG00000005580 AllianceGenome:MGI:108450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC9; ACtp10; D16Wsu65e; mKIAA0520
Summary
Enables adenylate cyclase activity. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; and in utero embryonic development. Located in membrane. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human ADCY9 (adenylate cyclase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 16.6), ovary adult (RPKM 14.2) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Adcy9 in Genome Data Viewer
Location:
16 A1; 16 2.42 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4102750..4255094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4284886..4437236, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene Neighboring gene predicted gene, 36359 Neighboring gene STARR-positive B cell enhancer ABC_E4153 Neighboring gene STARR-seq mESC enhancer starr_39924 Neighboring gene tubulin cofactor a pseudogene Neighboring gene sarcalumenin Neighboring gene STARR-positive B cell enhancer mm9_chr16:4541749-4542050 Neighboring gene transcription factor AP4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of I(Ks) Potassium Current by Isoproterenol in Adult Cardiomyocytes Requires Type 9 Adenylyl Cyclase. Li Y, et al. Cells, 2019 Aug 27. PMID 31461851, Free PMC Article
  2. ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein). Rautureau Y, et al. Circulation, 2018 Oct 16. PMID 29674325
  3. Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction. Li Y, et al. Sci Rep, 2017 Jul 17. PMID 28717248, Free PMC Article
  4. Identification of adenylyl cyclases by amplification using degenerate primers. Premont RT. Methods Enzymol, 1994. PMID 7528319
  5. Calcineurin feedback inhibition of agonist-evoked cAMP formation. Antoni FA, et al. J Biol Chem, 1995 Nov 24. PMID 7499291

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice.
    Title: Adcy9 Gene Inactivation Improves Cardiac Function After Myocardial Infarction in Mice.
  2. Adcy9 inactivation protects against atherosclerosis, but only in the absence of CETP activity. This atheroprotection may be explained by decreased macrophage accumulation and proliferation in the arterial wall, and improved endothelial function and autonomic tone.
    Title: ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein).
  3. Deletion of adenylyl cyclase type 9 results in a left ventricular diastolic dysfunction which correlates with reduced Hsp20-associated adenylyl cyclase type 9 activity and a significant 64% reduction in baseline Hsp20 phosphorylation.
    Title: Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction.
  4. in heart, Yotiao brings together PKA, PP1, PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
    Title: The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart.
  5. miR-142-3p regulates the production of cAMP by targeting adenylyl cyclase (AC) 9 messenger RNA in CD4(+)CD25(-) T cells and CD4(+)CD25(+) T(REG) cells.
    Title: miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate cyclase type 9
Names
ATP pyrophosphate-lyase 9
adenylate cyclase type IX
adenylyl cyclase 9
adenylyl cyclase type 10
NP_001278839.1
NP_001400201.1
NP_001400202.1
NP_033754.2
XP_011244108.1
XP_036015640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291910.2 → NP_001278839.1  adenylate cyclase type 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2), has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC087799, AC132575
    Consensus CDS
    CCDS79418.1
    UniProtKB/TrEMBL
    E9Q706
    Related
    ENSMUSP00000113421.2, ENSMUST00000120080.8
    Conserved Domains (2) summary
    smart00044
    Location:89 → 307
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:148 → 336
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

  2. NM_001413272.1 → NP_001400201.1  adenylate cyclase type 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC087799, AC132575

  3. NM_001413273.1 → NP_001400202.1  adenylate cyclase type 9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087799, AC132575
    UniProtKB/Swiss-Prot
    P51830, Q61279

  4. NM_009624.4 → NP_033754.2  adenylate cyclase type 9 isoform 1

    See identical proteins and their annotated locations for NP_033754.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087799, AC132575
    Consensus CDS
    CCDS27917.1
    UniProtKB/Swiss-Prot
    P51830, Q61279
    Related
    ENSMUSP00000113498.2, ENSMUST00000117801.8
    Conserved Domains (3) summary
    smart00044
    Location:326 → 544
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:385 → 573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam13515
    Location:142 → 202
    FUSC_2; Fusaric acid resistance protein-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4102750..4255094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245806.2 → XP_011244108.1  adenylate cyclase type 9 isoform X1

    See identical proteins and their annotated locations for XP_011244108.1

    Conserved Domains (2) summary
    pfam00211
    Location:385 → 573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    cl28910
    Location:134 → 260
    MFS; Major Facilitator Superfamily

  2. XM_036159747.1 → XP_036015640.1  adenylate cyclase type 9 isoform X2

    Conserved Domains (2) summary
    pfam00211
    Location:385 → 573
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    cl28910
    Location:134 → 260
    MFS; Major Facilitator Superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51830.1 GenPept UniProtKB/Swiss-Prot:P51830

Gene LinkOut

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