Adcy7 adenylate cyclase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy7provided by MGI
Official Full Name: adenylate cyclase 7provided by MGI
Primary source: MGI:MGI:102891
See related: Ensembl:ENSMUSG00000031659 AllianceGenome:MGI:102891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables adenylate cyclase activity. Involved in cellular response to lithium ion; negative regulation of cytokine production involved in inflammatory response; and regulation of adaptive immune response. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 30.9), lung adult (RPKM 18.8) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 43.06 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (88998818..89056593)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (88272190..88329965)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia.
Title: Role of Adenylyl Cyclase Type 7 in Functions of BV-2 Microglia.
Adenylyl cyclase 7 controls the extent of immune responses toward bacterial infection and is required for optimal functions of B and T cells during adaptive immune responses. It regulates cyclic adenosine monophosphate (cAMP) synthesis in B and T cells.
Title: Distinct roles of adenylyl cyclase VII in regulating the immune responses in mice.
AC7 is a specific downstream effector of the G(12/13) pathway
Title: Regulation of cAMP responses by the G12/13 pathway converges on adenylyl cyclase VII.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adcy7 (e-PCR), detects polymorphism
- UniSTS:495976

Adcy7 (e-PCR), detects polymorphism
- UniSTS:525198

D8Mit268 (e-PCR), detects polymorphism
- UniSTS:131478

RH124627 (e-PCR)
- UniSTS:161449

U12919 (e-PCR)
- UniSTS:125675

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cAMP biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytokine production involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: adenylate cyclase type 7

Names: ATP pyrophosphate-lyase 7; adenylate cyclase type VII; adenylyl cyclase 7; adenylyl cyclase type VII

NP_001032812.2

EC 4.6.1.1

NP_001032813.1

EC 4.6.1.1

NP_001103226.1

EC 4.6.1.1

NP_031432.2

EC 4.6.1.1

XP_006530643.1

EC 4.6.1.1

XP_011246579.1

EC 4.6.1.1

XP_011246580.1

EC 4.6.1.1

XP_011246581.1

EC 4.6.1.1

XP_011246582.1

EC 4.6.1.1

XP_011246583.1

EC 4.6.1.1

XP_011246584.1

EC 4.6.1.1

XP_030099104.1

EC 4.6.1.1

XP_036009618.1

EC 4.6.1.1

XP_036009619.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037723.3 → NP_001032812.2 adenylate cyclase type 7

See identical proteins and their annotated locations for NP_001032812.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK138911, AK155831, BB761797, BY208639

Consensus CDS

CCDS22509.1

UniProtKB/Swiss-Prot

P51829, Q3U3P2

UniProtKB/TrEMBL

Q3U1P1

Related

ENSMUSP00000132528.2, ENSMUST00000171456.9

Conserved Domains (4) summary

smart00044
Location:227 → 431

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:890 → 1086

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001037724.4 → NP_001032813.1 adenylate cyclase type 7

See identical proteins and their annotated locations for NP_001032813.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK138911, AK155831, BB761797, BY205086

Consensus CDS

CCDS22509.1

UniProtKB/Swiss-Prot

P51829, Q3U3P2

UniProtKB/TrEMBL

Q3U1P1

Related

ENSMUSP00000096122.3, ENSMUST00000098521.4

Conserved Domains (4) summary

smart00044
Location:227 → 431

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:890 → 1086

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_001109756.1 → NP_001103226.1 adenylate cyclase type 7

See identical proteins and their annotated locations for NP_001103226.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AK138911, AK155646, AK155831, BB761797

Consensus CDS

CCDS22509.1

UniProtKB/Swiss-Prot

P51829, Q3U3P2

UniProtKB/TrEMBL

Q3U1P1

Related

ENSMUSP00000129252.2, ENSMUST00000168545.8

Conserved Domains (4) summary

smart00044
Location:227 → 431

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:890 → 1086

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
NM_007406.2 → NP_031432.2 adenylate cyclase type 7

See identical proteins and their annotated locations for NP_031432.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.

Source sequence(s)

AC155170, AK138911, AK155831, BB761797, U12919

Consensus CDS

CCDS22509.1

UniProtKB/Swiss-Prot

P51829, Q3U3P2

UniProtKB/TrEMBL

Q3U1P1

Related

ENSMUSP00000130594.2, ENSMUST00000169037.9

Conserved Domains (4) summary

smart00044
Location:227 → 431

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:890 → 1086

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

88998818..89056593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030243244.1 → XP_030099104.1 adenylate cyclase type 7 isoform X1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_011248278.3 → XP_011246580.1 adenylate cyclase type 7 isoform X1

See identical proteins and their annotated locations for XP_011246580.1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_036153725.1 → XP_036009618.1 adenylate cyclase type 7 isoform X1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_011248279.3 → XP_011246581.1 adenylate cyclase type 7 isoform X1

See identical proteins and their annotated locations for XP_011246581.1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_011248277.3 → XP_011246579.1 adenylate cyclase type 7 isoform X1

See identical proteins and their annotated locations for XP_011246579.1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_011248282.3 → XP_011246584.1 adenylate cyclase type 7 isoform X2

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_036153726.1 → XP_036009619.1 adenylate cyclase type 7 isoform X3

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (4) summary

pfam00211
Location:272 → 422

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)

cl11967
Location:890 → 936

Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
XM_006530580.5 → XP_006530643.1 adenylate cyclase type 7 isoform X1

See identical proteins and their annotated locations for XP_006530643.1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_011248280.1 → XP_011246582.1 adenylate cyclase type 7 isoform X1

See identical proteins and their annotated locations for XP_011246582.1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)
XM_011248281.4 → XP_011246583.1 adenylate cyclase type 7 isoform X1

See identical proteins and their annotated locations for XP_011246583.1

UniProtKB/TrEMBL

Q3U1P1

Conserved Domains (3) summary

pfam00211
Location:890 → 1085

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:75 → 251

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:487 → 593

DUF1053; Domain of Unknown Function (DUF1053)