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Adcy6 adenylate cyclase 6 [ Mus musculus (house mouse) ]

Gene ID: 11512, updated on 21-Apr-2024

Summary

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Official Symbol
Adcy6provided by MGI
Official Full Name
adenylate cyclase 6provided by MGI
Primary source
MGI:MGI:87917
See related
Ensembl:ENSMUSG00000022994 AllianceGenome:MGI:87917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AC6; mKIAA0422
Summary
Enables calcium- and calmodulin-responsive adenylate cyclase activity and scaffold protein binding activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and cellular response to vasopressin. Is intrinsic component of plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; cardiovascular system; and genitourinary system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (adenylate cyclase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 45.5), thymus adult (RPKM 39.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 54.59 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98484982..98508119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98589978..98610287, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39662 Neighboring gene KAT8 regulatory NSL complex subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E946 Neighboring gene small nucleolar RNA, H/ACA box 2B Neighboring gene STARR-seq mESC enhancer starr_39663 Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1917 Neighboring gene sperm microtubule inner protein 11 Neighboring gene STARR-seq mESC enhancer starr_39665 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98440580-98440763 Neighboring gene STARR-positive B cell enhancer ABC_E9921 Neighboring gene STARR-seq mESC enhancer starr_39668 Neighboring gene calcium channel, voltage-dependent, beta 3 subunit Neighboring gene DEAD box helicase 23 Neighboring gene STARR-positive B cell enhancer ABC_E8612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea. Fenton RA, et al. J Infect Dis, 2019 Oct 22. PMID 30624615, Free PMC Article
  2. Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium. Johnson GP, et al. J Cell Sci, 2018 Nov 8. PMID 30301777
  3. The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway. Wu YS, et al. J Biomed Sci, 2017 Sep 4. PMID 28870220, Free PMC Article
  4. Cardiac-directed expression of a catalytically inactive adenylyl cyclase 6 protects the heart from sustained β-adrenergic stimulation. Gao MH, et al. PLoS One, 2017. PMID 28767701, Free PMC Article
  5. Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus. Poulsen SB, et al. JCI Insight, 2017 Apr 6. PMID 28405619, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.
    Title: Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.
  2. AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.
    Title: AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.
  3. Purbeta promotes hepatic glucose production by increasing Adcy6 transcription.
    Title: Purβ promotes hepatic glucose production by increasing Adcy6 transcription.
  4. Cholera toxin-induced fluid accumulation in vivo was completely absent in AC6 knockout mice mice, associated with a lack of forskolin.
    Title: Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea.
  5. AC6 is tightly regulated by intrinsic receptor-independent Gi activity.
    Title: Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.
  6. Authors demonstrate that this mechanosignalling is dependent on the primary cilium and the ciliary localised adenylyl cyclase 6.
    Title: Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium.
  7. Under baseline conditions, renal adenylate cyclase 6 (AC6) is redundant for acid-base balance but becomes important under alkaline conditions.
    Title: Adenylyl cyclase 6 is required for maintaining acid-base homeostasis.
  8. AC6 has a minor role in lithium-induced nephrogenic diabetes insipidus development but may be important for determining the intercalated cell-to-principal cell ratio.
    Title: Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.
  9. Immunofluorescence staining revealed that cardiac AC6 was mainly anchored on the sarcolemmal membranes, while AC6-DeltaN was redistributed to the sarcoplasmic reticulum. AC6(DeltaN/DeltaN) and AC6(-/-) mice had more apoptotic myocytes and cardiac remodeling than WT mice in experimental models of isoproterenol (ISO)-induced myocardial injury.
    Title: The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway.
  10. GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6(-/-) mice without altering the gross anatomy of the brain
    Title: Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium- and calmodulin-responsive adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium- and calmodulin-responsive adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in blood vessel diameter maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to forskolin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to vasopressin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of protein location in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in renal water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate cyclase type 6
Names
ATP pyrophosphate-lyase 6
adenylate cyclase type VI
adenylyl cyclase 6
ca(2+)-inhibitable adenylyl cyclase
NP_001355342.1
NP_001397290.1
NP_001397291.1
NP_001397292.1
NP_001397293.1
NP_001397294.1
NP_001397295.1
NP_001397296.1
NP_001397297.1
XP_006520366.3
XP_036014969.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368413.2 → NP_001355342.1  adenylate cyclase type 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138221
    Consensus CDS
    CCDS88833.1
    UniProtKB/TrEMBL
    A0A2I3BRC5, F8VQ52
    Related
    ENSMUSP00000093939.5, ENSMUST00000096224.6
    Conserved Domains (3) summary
    pfam00211
    Location:968 → 1162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14 → 366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580 → 666
    DUF1053; Domain of Unknown Function (DUF1053)

  2. NM_001410361.1 → NP_001397290.1  adenylate cyclase type 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138221
    UniProtKB/TrEMBL
    A0A2I3BRC5

  3. NM_001410362.1 → NP_001397291.1  adenylate cyclase type 6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138221

  4. NM_001410363.1 → NP_001397292.1  adenylate cyclase type 6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138221

  5. NM_001410364.1 → NP_001397293.1  adenylate cyclase type 6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC138221
    UniProtKB/TrEMBL
    A0A2I3BRC5

  6. NM_001410365.1 → NP_001397294.1  adenylate cyclase type 6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138221

  7. NM_001410366.1 → NP_001397295.1  adenylate cyclase type 6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138221

  8. NM_001410367.1 → NP_001397296.1  adenylate cyclase type 6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC138221

  9. NM_001410368.1 → NP_001397297.1  adenylate cyclase type 6 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC138221

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98484982..98508119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520303.5 → XP_006520366.3  adenylate cyclase type 6 isoform X1

    UniProtKB/TrEMBL
    F8VQ52
    Conserved Domains (3) summary
    pfam00211
    Location:1056 → 1250
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:83 → 454
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:668 → 754
    DUF1053; Domain of Unknown Function (DUF1053)

  2. XM_036159076.1 → XP_036014969.1  adenylate cyclase type 6 isoform X5

    UniProtKB/TrEMBL
    A0A2I3BRC5, F8VQ52
    Related
    ENSMUSP00000154421.2, ENSMUST00000228566.2
    Conserved Domains (3) summary
    pfam00211
    Location:968 → 1162
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:14 → 366
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    pfam06327
    Location:580 → 666
    DUF1053; Domain of Unknown Function (DUF1053)

RNA

  1. XR_004938786.1 RNA Sequence

  2. XR_001781491.3 RNA Sequence

  3. XR_004938785.1 RNA Sequence

  4. XR_383972.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007405.3: Suppressed sequence

    Description
    NM_007405.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01341.1 GenPept UniProtKB/Swiss-Prot:Q01341

Gene LinkOut

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