Shc3 SHC adaptor protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Shc3provided by RGD
Official Full Name: SHC adaptor protein 3provided by RGD
Primary source: RGD:69348
See related: Ensembl:ENSRNOG00000014366 AllianceGenome:RGD:69348
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ShcC
Summary: Predicted to enable phosphotyrosine residue binding activity and receptor tyrosine kinase binding activity. Predicted to be involved in transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within glutamatergic synaptic transmission and learning or memory. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human SHC3 (SHC adaptor protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 88.8), Adrenal (RPKM 22.8) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (13803980..13924433)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (13652247..13772710)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (13670520..13791043)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that p52SHC3 plays an important role in maintaining the mitotic quiescence of neurons, while p52SHC1 regulates the proliferation of neural stem cells
Title: Different Effects of p52SHC1 and p52SHC3 on the Cell Cycle of Neurons and Neural Stem Cells.
data show that the regulation of Shc mRNAs in senescence is region as well as isoform specific
Title: Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment.
ShcC could be a potential phosphotyrosine adapter among the Shc family members for BDNF signaling and function during retinal development.
Title: Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulation.
modulation of phosphorylation and biophysics by combined effect of src kinase, Grb10 and n-Shc adaptor proteins (Kv1.3)
Title: Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase.

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General gene information

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Markers

Shc3 (e-PCR), detects polymorphism
- UniSTS:532501

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	TAS Traceable Author Statement more info	PubMed
enables protein tyrosine kinase activity	TAS Traceable Author Statement more info
enables receptor tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SHC-transforming protein 3

Names: N-Shc; SH2 domain protein C3; SHC (Src homology 2 domain containing) transforming protein 3; SHC-transforming protein C; neuronal Shc; src homology 2 domain-containing transforming protein C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105743.1 → NP_001099213.1 SHC-transforming protein 3

See identical proteins and their annotated locations for NP_001099213.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/Swiss-Prot

O70143

UniProtKB/TrEMBL

A6J6U1, G3V7V0

Related

ENSRNOP00000019442.2, ENSRNOT00000019442.4

Conserved Domains (2) summary

cd09925
Location:492 → 594

SH2_SHC; Src homology 2 (SH2) domain found in SH2 adaptor protein C (SHC)

cd01209
Location:139 → 310

PTB_Shc; Shc-like phosphotyrosine-binding (PTB) domain