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Zyx zyxin [ Rattus norvegicus (Norway rat) ]

Gene ID: 114636, updated on 13-Apr-2024

Summary

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Official Symbol
Zyxprovided by RGD
Official Full Name
zyxinprovided by RGD
Primary source
RGD:620698
See related
Ensembl:ENSRNOG00000017354 AllianceGenome:RGD:620698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable metal ion binding activity. Involved in regulation of inflammatory response. Predicted to be located in several cellular components, including actin cytoskeleton; adherens junction; and phagocytic vesicle. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 240.8), Spleen (RPKM 168.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zyx in Genome Data Viewer
Location:
4q24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (72203991..72213181)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (71236767..71246553)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (71740188..71749386)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene chloride voltage-gated channel 1 Neighboring gene family with sequence similarity 131, member B Neighboring gene uncharacterized LOC120102260 Neighboring gene Eph receptor A1 Neighboring gene uncharacterized LOC120102261 Neighboring gene taste receptor, type 2, member 143

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of VASP and zyxin in cochlear pillar cells: indication for actin-based dynamics? Schick B, et al. Cell Tissue Res, 2003 Mar. PMID 12658439
  2. Focal adhesion protein zyxin is a mechanosensitive modulator of gene expression in vascular smooth muscle cells. Cattaruzza M, et al. Hypertension, 2004 Apr. PMID 14967842
  3. Molecular characterization of human zyxin. Macalma T, et al. J Biol Chem, 1996 Dec 6. PMID 8940160
  4. The LIM-domain protein Zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo. Martynova NY, et al. Dev Dyn, 2008 Mar. PMID 18297730
  5. Cytokine-induced down-regulation of zfm1/splicing factor-1 promotes smooth muscle cell proliferation. Cattaruzza M, et al. J Biol Chem, 2002 Feb 22. PMID 11748220

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zyxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398717.2 → NP_001385646.1  zyxin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    Related
    ENSRNOP00000094013.1, ENSRNOT00000115210.1
    Conserved Domains (5) summary
    cd09353
    Location:436 → 495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496 → 562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:3 → 295
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:177 → 396
    PRK10263; DNA translocase FtsK; Provisional
    cl02475
    Location:343 → 429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001398718.2 → NP_001385647.1  zyxin isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6AV84
    Related
    ENSRNOP00000097981.1, ENSRNOT00000104565.1

  3. NM_001415801.1 → NP_001402730.1  zyxin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

  4. NM_053761.3 → NP_446213.1  zyxin isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I6GKY5, A6IF73
    Related
    ENSRNOP00000023537.6, ENSRNOT00000023537.6
    Conserved Domains (5) summary
    cd09353
    Location:436 → 495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496 → 562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:3 → 295
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:177 → 396
    PRK10263; DNA translocase FtsK; Provisional
    cl02475
    Location:343 → 429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    72203991..72213181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017592382.3 → XP_017447871.1  zyxin isoform X2

    UniProtKB/TrEMBL
    A0A8I6GKY5, A6IF73
    Conserved Domains (5) summary
    cd09353
    Location:436 → 495
    LIM2_Zyxin; The second LIM domain of Zyxin
    cd09435
    Location:496 → 562
    LIM3_Zyxin; The third LIM domain of Zyxin
    PHA03247
    Location:3 → 295
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:177 → 396
    PRK10263; DNA translocase FtsK; Provisional
    cl02475
    Location:343 → 429
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_063285399.1 → XP_063141469.1  zyxin isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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