Dlk1 delta like non-canonical Notch ligand 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dlk1provided by RGD
Official Full Name: delta like non-canonical Notch ligand 1provided by RGD
Primary source: RGD:619931
See related: Ensembl:ENSRNOG00000019584 AllianceGenome:RGD:619931
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zog; DLK-1; Pref-1
Summary: Predicted to enable calcium ion binding activity. Involved in cell differentiation. Predicted to be located in external side of plasma membrane and extracellular space. Predicted to be active in membrane. Orthologous to human DLK1 (delta like non-canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 656.8), Muscle (RPKM 126.9) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (134192491..134199779)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (128410216..128417518)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (133576513..133583751)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
Title: The pituitary tumour-transforming gene 1/delta-like homologue 1 pathway plays a key role in liver fibrogenesis.
Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.
Title: Functional characterization of DLK1/MEG3 locus on chromosome 14q32.2 reveals the differentiation of pituitary neuroendocrine tumors.
Decreased Dlk1 expression relates to visceral fat expansion and insulin resistance in a rat model of catch-up growth following prenatal growth restriction
Title: Dlk1 expression relates to visceral fat expansion and insulin resistance in male and female rats with postnatal catch-up growth.
Adipocyte progenitor cells are involved in the rat mesenteric lymph node (MLN) development through differentiation into fibroblastic reticular cells or follicular dendritic cells; expression of the relevant chemokines during the development of MLNs is dynamic and may be related to the maintenance of lymph nodes self-balance state.
Title: Expression of Pref-1 and Related Chemokines during theDevelopment of Rat Mesenteric Lymph Nodes.
Neither of the two doses of FLX has significantly affected the Pref-1 expression in any type of adipose tissue.
Title: Chronic fluoxetine treatment induces lipid accumulation but does not alter the expression of Pref-1 in rat adipose tissue.
Pref-1 induces insulin synthesis and secretion via two independent pathways
Title: Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells.
The differential expression of FA1/dlk1 in the SNc and the striatum of dopamine-depleted rats could indicate a potential involvement of FA1/dlk1 in the cellular response to the degenerative processes.
Title: Characterization of fetal antigen 1/delta-like 1 homologue expressing cells in the rat nigrostriatal system: effects of a unilateral 6-hydroxydopamine lesion.
The Dlk1-Dio3-imprinted domain on 6q32, is associated with the syntenic human locus in schizophrenia.
Title: Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure.
Study shows that the expression of hypothalamus-enriched DLK1 is regulated by nutritional challenge and that the DLK1 protein is present in many neurons of the arcuate nucleus, the ventromedial subdivision in particular
Title: Delta-like 1 homologue (DLK1) protein in neurons of the arcuate nucleus that control weight homeostasis and effect of fasting on hypothalamic DLK1 mRNA.
presence of DLK1 in a population of lateral hypothalamic neurones suggests a functional role for DLK1 in orexin/hypocretin/dynorphin neurones
Title: Delta-like 1 homologue is a hypothalamus-enriched protein that is present in orexin-containing neurones of the lateral hypothalamic area.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

Dlk1 (e-PCR), detects polymorphism
- UniSTS:142852

Dlk1 (e-PCR), detects polymorphism
- UniSTS:526856

BE115497 (e-PCR)
- UniSTS:248164

UniSTS:259449 (e-PCR)
- UniSTS:259449

Dlk1 (e-PCR), detects polymorphism
- UniSTS:259449

Dlk1 (e-PCR), detects polymorphism
- UniSTS:532135

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein delta homolog 1

Names: delta-like 1 homolog; preadipocyte factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053744.2 → NP_446196.1 protein delta homolog 1 precursor

See identical proteins and their annotated locations for NP_446196.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

O70534, Q62779

UniProtKB/TrEMBL

A6KBJ4

Related

ENSRNOP00000069391.1, ENSRNOT00000085933.2

Conserved Domains (1) summary

cd00054
Location:88 → 125

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

134192491..134199779

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008764917.3 → XP_008763139.1 protein delta homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8I6GDQ5, A6KBJ4

Related

ENSRNOP00000086145.1

Conserved Domains (1) summary

cd00054
Location:88 → 125

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_063261397.1 → XP_063117467.1 protein delta homolog 1 isoform X2