pklr pyruvate kinase L/R [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pklrprovided by ZNC
Official Full Name: pyruvate kinase L/Rprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010907-1
See related: Ensembl:ENSDARG00000042010 AllianceGenome:ZFIN:ZDB-GENE-010907-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fd15e01; wu:fi37e08
Summary: Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and pyruvate kinase activity. Acts upstream of or within liver development. Is expressed in female organism; heart; intestine; liver; and male organism. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (54450407..54458919, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (54629441..54634683, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW171121 (e-PCR)
- UniSTS:205858

z1786 (e-PCR), detects polymorphism
- UniSTS:205152

fc08e12.x1 (e-PCR)
- UniSTS:192354

fc08e12.x1 (e-PCR)
- UniSTS:192355

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables potassium ion binding	IEA Inferred from Electronic Annotation more info
enables pyruvate kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pyruvate kinase PKLR

Names: pyruvate kinase, liver and RBC

NP_958446.1

EC 2.7.1.40

XP_021322272.1

EC 2.7.1.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201289.1 → NP_958446.1 pyruvate kinase PKLR

See identical proteins and their annotated locations for NP_958446.1

Status: PROVISIONAL

Source sequence(s)

BC055561

UniProtKB/TrEMBL

Q7SXK3

Related

ENSDARP00000069759.5, ENSDART00000075275.6

Conserved Domains (2) summary

cd00288
Location:48 → 537

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...

TIGR01064
Location:49 → 533

pyruv_kin; pyruvate kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

54450407..54458919 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466597.1 → XP_021322272.1 pyruvate kinase PKLR isoform X1

UniProtKB/TrEMBL

A0A8M9NZ14

Conserved Domains (1) summary

cd00288
Location:37 → 526

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...