ache acetylcholinesterase (Yt blood group) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: acheprovided by ZNC
Official Full Name: acetylcholinesterase (Yt blood group)provided by ZNC
Primary source: ZFIN:ZDB-GENE-010906-1
See related: Ensembl:ENSDARG00000031796 AllianceGenome:ZFIN:ZDB-GENE-010906-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92550
Summary: Enables acetylcholinesterase activity. Acts upstream of or within several processes, including acetylcholine catabolic process; cellular response to methanol; and response to amphetamine. Predicted to be located in extracellular region; membrane; and synapse. Predicted to be active in extracellular space and plasma membrane. Is expressed in several structures, including female organism; male organism; myotome; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (26077153..26087817, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (25808242..25816662, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish.
Title: TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish.
Endosulfan exposure inhibits brain Ache activity and significantly impairs animals' exploratory performance, and potentially compromises their ecological and interspecific interaction.
Title: Endosulfan exposure inhibits brain AChE activity and impairs swimming performance in adult zebrafish (Danio rerio).
Findings provide evidence that brain acetylcholinesterase (AChE) is a potential target for microcystins (MCs).
Title: Microcystin-LR acute exposure increases AChE activity via transcriptional ache activation in zebrafish (Danio rerio) brain.
aryl acylamidase associated with acetylcholinesterase was higher than the esterase activity on zebrafishembryo
Title: Expression of acetylcholinesterase (AChE) and aryl acylamidase (AAA) during early zebrafish embryogenesis.
Results demonstrate that AChE is dispensable for its proposed non-classical roles in muscle fiber formation and sensory neuron development, but is crucial for regulating the stability of neuromuscular synapses.
Title: Acetylcholinesterase function is dispensable for sensory neurite growth but is critical for neuromuscular synapse stability.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables acetylcholinesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholinesterase activity	IDA Inferred from Direct Assay more info
enables acetylcholinesterase activity	IEA Inferred from Electronic Annotation more info
enables acetylcholinesterase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables cholinesterase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetylcholine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acetylcholine catabolic process	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within acetylcholine catabolic process	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within cellular response to methanol	IDA Inferred from Direct Assay more info	PubMed
involved_in choline metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within neuromuscular junction development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to amphetamine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethanol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to glucose	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acetylcholinesterase

Names: ziehharmonika; zim

NP_571921.1

EC 3.1.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.