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Map2k6 mitogen-activated protein kinase kinase 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114495, updated on 11-Apr-2024

Summary

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Official Symbol
Map2k6provided by RGD
Official Full Name
mitogen-activated protein kinase kinase 6provided by RGD
Primary source
RGD:620666
See related
Ensembl:ENSRNOG00000004437 AllianceGenome:RGD:620666
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mkk6
Summary
Enables MAP kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Predicted to be located in cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 174.7), Thymus (RPKM 86.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q32.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (95872747..95987747)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (95373304..95490406)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (98707160..98823054)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily A member 6 Neighboring gene ATP binding cassette subfamily A member 5 Neighboring gene uncharacterized LOC102551705 Neighboring gene uncharacterized LOC108352228

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Different effects of amlodipine and enalapril on the mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-extracellular signal-regulated kinase pathway for induction of vascular smooth muscle cell differentiation in vivo. Umemoto S, et al. Hypertens Res, 2006 Mar. PMID 16755153
  2. The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT. Andrews C, et al. Cardiovasc Res, 2003 Jul 1. PMID 12829175
  3. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Degousee N, et al. Circ Res, 2003 Apr 18. PMID 12649265
  4. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Hartzler AW, et al. Neurobiol Aging, 2002 Sep-Oct. PMID 12392790
  5. Developmental regulation of mitogen-activated protein kinase-activated kinases-2 and -3 (MAPKAPK-2/-3) in vivo during corpus luteum formation in the rat. Maizels ET, et al. Mol Endocrinol, 2001 May. PMID 11328854

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Serine phosphorylation of p66shc is carried out by active MKK6. beta-Amyloid-induced ROS production and apoptosis increased in the presence of MKK6 and p66shc, which directly associate.
    Title: β-Amyloid-evoked apoptotic cell death is mediated through MKK6-p66shc pathway.
  2. The models confirmed the reaction order, revealed processivity in the phosphorylation of MEK6 by ASK1, and suggested that the order of phosphorylation is dictated by both binding and catalysis rates.
    Title: Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascade.
  3. Rap1, MKK3/6, and p38 MAPK have a role in the induction of mGluR-dependent LTD by directly coupling to receptor trafficking machineries to facilitate the loss of synaptic AMPA receptors
    Title: Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93287

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables MAP kinase kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in bone development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to sorbitol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in ovulation cycle process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity mitogen-activated protein kinase kinase 6
NP_446155.1
XP_038940961.1
XP_038940962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053703.3 → NP_446155.1  dual specificity mitogen-activated protein kinase kinase 6

    See identical proteins and their annotated locations for NP_446155.1

    Status: PROVISIONAL

    Source sequence(s)
    AF369384
    UniProtKB/TrEMBL
    A6HKD4, F7EK55, Q925D6
    Related
    ENSRNOP00000006217.3, ENSRNOT00000006217.7
    Conserved Domains (1) summary
    cd06617
    Location:51 → 333
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    95872747..95987747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085034.2 → XP_038940962.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

    UniProtKB/TrEMBL
    A6HKD7
    Conserved Domains (1) summary
    cd06617
    Location:1 → 264
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

  2. XM_039085033.2 → XP_038940961.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

    UniProtKB/TrEMBL
    A6HKD7
    Conserved Domains (1) summary
    cd06617
    Location:1 → 264
    PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
Nucleotide Protein Strain
Heading Accession and Version

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