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Ccna2 cyclin A2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114494, updated on 5-Mar-2024

Summary

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Official Symbol
Ccna2provided by RGD
Official Full Name
cyclin A2provided by RGD
Primary source
RGD:621059
See related
Ensembl:ENSRNOG00000015423 AllianceGenome:RGD:621059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity; protein domain specific binding activity; and protein kinase binding activity. Involved in several processes, including cellular response to nitric oxide; cellular response to organic cyclic compound; and response to peptide hormone. Located in nucleus. Biomarker of myocardial infarction. Orthologous to human CCNA2 (cyclin A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 275.4), Spleen (RPKM 179.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q25
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121355363..121361762, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (119427239..119433645, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123274727..123282266, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 43 Neighboring gene exosome component 9 Neighboring gene Bardet-Biedl syndrome 7 Neighboring gene transient receptor potential cation channel, subfamily C, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Overexpression of CyclinA2 ameliorates hypoxia-impaired proliferation of cardiomyocytes. Deng H, et al. Exp Ther Med, 2014 Nov. PMID 25289051, Free PMC Article
  2. Acute myocardial infarction induced functional cardiomyocytes to re-enter the cell cycle. Li Y, et al. Am J Transl Res, 2013. PMID 23634243, Free PMC Article
  3. Decreased level of cyclin A2 in rat cochlea development and cochlear stem cell differentiation. Chen J, et al. Neurosci Lett, 2009 Apr 10. PMID 19429027
  4. A mechanism for the inhibition of neural progenitor cell proliferation by cocaine. Lee CT, et al. PLoS Med, 2008 Jun 10. PMID 18593214, Free PMC Article
  5. Myocardial regeneration therapy for ischemic cardiomyopathy with cyclin A2. Woo YJ, et al. J Thorac Cardiovasc Surg, 2007 Apr. PMID 17382628

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPINK3 along with Ccna2 and EGFR accelerated cell proliferation during rat liver regeneration via P38 MAPK, PKC, JAK-STAT and AKT pathways.
    Title: [SPINK3: A novel growth factor that promotes rat liver regeneration].
  2. Cyclin A2 might be involved in the modulation of rat cochlea development and cochlear stem cell differentiation.
    Title: Decreased level of cyclin A2 in rat cochlea development and cochlear stem cell differentiation.
  3. Fra-1 induction is important in thyroid tumorigenesis, critically regulating cyclin expression and cell-cycle progression.[Cyclin A]
    Title: Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcription.
  4. c-Jun is a mediator of the aberrant cyclin A2 expression associated with Ras/Src-induced transformation
    Title: Cyclin A is a c-Jun target gene and is necessary for c-Jun-induced anchorage-independent growth in RAT1a cells.
  5. leptin-induced decrease in cyclin A2 and subsequent increase in cyclin D1 expression precedes a leptin-triggered decrease in the number of prepubertal Leydig cells
    Title: Leptin-mediated decrease of cyclin A2 and increase of cyclin D1 expression: relevance for the control of prepubertal rat Leydig cell division and differentiation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC156527

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cocaine IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to insulin-like growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to leptin stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to luteinizing hormone stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to organic cyclic compound IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to platelet-derived growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cochlea development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to glucagon IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin A2-CDK1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin A2-CDK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin A2-CDK2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in female pronucleus ISO
Inferred from Sequence Orthology
more info
  
located_in male pronucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053702.3 → NP_446154.3  cyclin-A2

    See identical proteins and their annotated locations for NP_446154.3

    Status: VALIDATED

    Source sequence(s)
    AF367448, CK845133, CV114678, DY317814, DY551463
    UniProtKB/TrEMBL
    A0A0G2JVY9, A6IHY4
    Related
    ENSRNOP00000069674.2, ENSRNOT00000079745.2
    Conserved Domains (3) summary
    pfam00134
    Location:167 → 293
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:295 → 413
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:17 → 147
    Cyclin_N2; N-terminal region of cyclin_N

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    121355363..121361762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760903.4 → XP_008759125.1  cyclin-A2 isoform X2

    Conserved Domains (3) summary
    pfam00134
    Location:194 → 320
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:322 → 440
    Cyclin_C; Cyclin, C-terminal domain
    pfam16500
    Location:17 → 174
    Cyclin_N2; N-terminal region of cyclin_N

  2. XM_006232266.5 → XP_006232328.1  cyclin-A2 isoform X1

    UniProtKB/TrEMBL
    G3V802, Q6GX88
    Related
    ENSRNOP00000021156.5
    Conserved Domains (2) summary
    pfam00134
    Location:129 → 255
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:257 → 375
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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