spry4 sprouty homolog 4 (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: spry4provided by ZNC
Official Full Name: sprouty homolog 4 (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-010803-2
See related: Ensembl:ENSDARG00000068732 AllianceGenome:ZFIN:ZDB-GENE-010803-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb511; zSpry4; sprouty4; wu:fb92b06
Summary: Acts upstream of or within animal organ development and negative regulation of fibroblast growth factor receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in cytosol. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (44684441..44691068)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (44605062..44610571, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.
Title: Hindbrain patterning requires fine-tuning of early krox20 transcription by Sprouty 4.

Submit: New GeneRIF Correction

General gene information

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Markers

AI584848 (e-PCR)
- UniSTS:206222

fb92b06.x1 (e-PCR)
- UniSTS:203508

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rhombomere formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein sprouty homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131826.2 → NP_571901.2 protein sprouty homolog 4

Status: VALIDATED

Source sequence(s)

CABZ01085217, EH447258

UniProtKB/TrEMBL

A0A8M9PQ80, F1QZW4, Q90XH4

Related

ENSDARP00000090302.3, ENSDART00000099528.4

Conserved Domains (1) summary

pfam05210
Location:179 → 276

Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007132.7 Reference GRCz11 Primary Assembly

Range

44684441..44691068

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468746.1 → XP_021324421.1 protein sprouty homolog 4 isoform X1

UniProtKB/TrEMBL

A0A8M9PQ80, F1QZW4, Q90XH4

Conserved Domains (1) summary

pfam05210
Location:179 → 276

Sprouty; Sprouty protein (Spry)