mpz myelin protein zero [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mpzprovided by ZNC
Official Full Name: myelin protein zeroprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010724-4
See related: Ensembl:ENSDARG00000038609 AllianceGenome:ZFIN:ZDB-GENE-010724-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p0; sc:d0186; wu:fc04b11; wu:fi30g06; zgc:103775
Summary: Predicted to be involved in myelination. Located in myelin sheath. Is expressed in several structures, including Rohon-Beard neurons; basal plate midbrain region; central nervous system; cranial nerve; and oligodendrocyte. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple). Orthologous to human MPZ (myelin protein zero). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (44259484..44282931, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (44406484..44429923, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results of this study demonstrated that myelin protein zero promoter-driven mEGFP accumulation/fluorescence intensity can be used to rapidly and noninvasively follow myelin membrane production in the spinal cords of developing zebrafish larvae.
Title: A novel myelin protein zero transgenic zebrafish designed for rapid readout of in vivo myelination.
Up-regulation of the mpz:egfp transgene was not dependent on axonal regeneration, suggesting that the primary signal may be axonal loss, debris, or microglial infiltration
Title: Different mechanisms regulate expression of zebrafish myelin protein zero (P0) in myelinating oligodendrocytes and its induction following axonal injury.
These data provide a detailed account of P0 expression and demonstrate novel P0 isoforms, which may have discrete functional properties.
Title: Major isoform of zebrafish P0 is a 23.5 kDa myelin glycoprotein expressed in selected white matter tracts of the central nervous system.
the adhesive role of P0 at the cytoplasmic apposition in compact myelin depends on the cytoplasmic domain of P0 being in the beta-conformation
Title: Cytoplasmic domain of zebrafish myelin protein zero: adhesive role depends on beta-conformation.
The glial upregulation of P0 mRNA expression after a lesion of the adult zebrafish CNS suggests roles for P0 in promoting axon regeneration and remyelination after injury.
Title: Expression of protein zero is increased in lesioned axon pathways in the central nervous system of adult zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fc04b11.x1 (e-PCR)
- UniSTS:187698

fc24f10.y1 (e-PCR)
- UniSTS:193211

AW174967 (e-PCR)
- UniSTS:205794

fi30g06.x1 (e-PCR)
- UniSTS:204540

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in myelination	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: myelin protein P0

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194361.2 → NP_919342.1 myelin protein P0 precursor

See identical proteins and their annotated locations for NP_919342.1

Status: PROVISIONAL

Source sequence(s)

AJ489219

UniProtKB/TrEMBL

A0A8M1PEP3, Q8JFG6

Related

ENSDARP00000101478.2, ENSDART00000109251.4

Conserved Domains (2) summary

cd05879
Location:23 → 138

Ig_P0; Immunoglobulin (Ig)-like domain of Protein zero (P0)

smart00410
Location:31 → 138

IG_like; Immunoglobulin like