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Sh2b2 SH2B adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114203, updated on 13-Apr-2024

Summary

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Official Symbol
Sh2b2provided by RGD
Official Full Name
SH2B adaptor protein 2provided by RGD
Primary source
RGD:69284
See related
Ensembl:ENSRNOG00000001425 AllianceGenome:RGD:69284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aps
Summary
Enables identical protein binding activity. Involved in nervous system development and regulation of Ras protein signal transduction. Predicted to be located in actin cytoskeleton; cytosol; and ruffle. Predicted to be active in plasma membrane. Orthologous to human SH2B2 (SH2B adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 43.7), Thymus (RPKM 33.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh2b2 in Genome Data Viewer
Location:
12q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26063812..26093468)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20427057..20456845)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23471477..23501043)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481274 Neighboring gene uncharacterized LOC134481273 Neighboring gene cut-like homeobox 1 Neighboring gene uncharacterized LOC134481275 Neighboring gene uncharacterized LOC134481276 Neighboring gene PRKR interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains. Iseki M, et al. Mol Cell Biol, 2004 Mar. PMID 14993264, Free PMC Article
  2. Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor. Hu J, et al. Mol Cell, 2003 Dec. PMID 14690593
  3. Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. Hu J, et al. J Mol Biol, 2006 Aug 4. PMID 16824542
  4. Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. Katsanakis KD, et al. J Biol Chem, 2005 Nov 11. PMID 16141217
  5. Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. Wilcox A, et al. J Biol Chem, 2004 Sep 10. PMID 15231829

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. APS was identified as a novel substrate for protein kinase B/Akt.
    Title: Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within B-1 B cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen receptor-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin filament ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH2B adapter protein 2
Names
SH2 and PH domain-containing adapter protein APS
adapter protein with pleckstrin homology and Src homology 2 domains
adaptor protein with pleckstrin homology and src homology 2 domains

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053669.2 → NP_446121.1  SH2B adapter protein 2

    See identical proteins and their annotated locations for NP_446121.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q9Z200
    UniProtKB/TrEMBL
    A0A8I6GLZ7, A6J076
    Related
    ENSRNOP00000001935.5, ENSRNOT00000001935.6
    Conserved Domains (5) summary
    cd10411
    Location:401 → 496
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:186 → 301
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 295
    PH; PH domain
    pfam08916
    Location:17 → 73
    Phe_ZIP; Phenylalanine zipper
    cl00807
    Location:149 → 172
    MNHE; Na+/H+ ion antiporter subunit

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26063812..26093468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089010.2 → XP_038944938.1  SH2B adapter protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLZ7
    Conserved Domains (3) summary
    cd10411
    Location:434 → 529
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:220 → 335
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam08916
    Location:51 → 107
    Phe_ZIP; Phenylalanine zipper

  2. XM_008769112.4 → XP_008767334.1  SH2B adapter protein 2 isoform X1

    See identical proteins and their annotated locations for XP_008767334.1

    UniProtKB/TrEMBL
    A0A8I6GLZ7
    Conserved Domains (5) summary
    cd10411
    Location:435 → 530
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:220 → 335
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:238 → 329
    PH; PH domain
    pfam08916
    Location:51 → 107
    Phe_ZIP; Phenylalanine zipper
    cl00807
    Location:183 → 206
    MNHE; Na+/H+ ion antiporter subunit

  3. XM_017598239.3 → XP_017453728.1  SH2B adapter protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9Z200
    UniProtKB/TrEMBL
    A0A8I6GLZ7, A6J076
    Conserved Domains (5) summary
    cd10411
    Location:401 → 496
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:186 → 301
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 295
    PH; PH domain
    pfam08916
    Location:17 → 73
    Phe_ZIP; Phenylalanine zipper
    cl00807
    Location:149 → 172
    MNHE; Na+/H+ ion antiporter subunit

  4. XM_008769113.4 → XP_008767335.1  SH2B adapter protein 2 isoform X3

    See identical proteins and their annotated locations for XP_008767335.1

    UniProtKB/Swiss-Prot
    Q9Z200
    UniProtKB/TrEMBL
    A0A8I6GLZ7, A6J076
    Conserved Domains (5) summary
    cd10411
    Location:401 → 496
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:186 → 301
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 295
    PH; PH domain
    pfam08916
    Location:17 → 73
    Phe_ZIP; Phenylalanine zipper
    cl00807
    Location:149 → 172
    MNHE; Na+/H+ ion antiporter subunit

  5. XM_017598238.3 → XP_017453727.1  SH2B adapter protein 2 isoform X3

    UniProtKB/Swiss-Prot
    Q9Z200
    UniProtKB/TrEMBL
    A0A8I6GLZ7, A6J076
    Conserved Domains (5) summary
    cd10411
    Location:401 → 496
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:186 → 301
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    pfam00169
    Location:204 → 295
    PH; PH domain
    pfam08916
    Location:17 → 73
    Phe_ZIP; Phenylalanine zipper
    cl00807
    Location:149 → 172
    MNHE; Na+/H+ ion antiporter subunit
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z200.1 GenPept UniProtKB/Swiss-Prot:Q9Z200

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