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Gng12 G protein subunit gamma 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114120, updated on 11-Apr-2024

Summary

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Official Symbol
Gng12provided by RGD
Official Full Name
G protein subunit gamma 12provided by RGD
Primary source
RGD:621516
See related
Ensembl:ENSRNOG00000050231 AllianceGenome:RGD:621516
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hg3a
Summary
Enables phosphate ion binding activity. Involved in cerebral cortex development and response to lipopolysaccharide. Colocalizes with actin filament. Orthologous to human GNG12 (G protein subunit gamma 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 174.9), Adrenal (RPKM 104.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gng12 in Genome Data Viewer
Location:
4q31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (97340830..97464422)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (96011118..96134767)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (97634925..97763478)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene mitotic arrest deficient 2 like 1 Neighboring gene vomeronasal 1 receptor 89 Neighboring gene uncharacterized LOC100912188 Neighboring gene growth arrest and DNA-damage-inducible, alpha Neighboring gene uncharacterized LOC120102291 Neighboring gene Serpine1 mRNA binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo. Asano T, et al. Eur J Biochem, 1998 Jan 15. PMID 9492299
  2. Gng12 is a novel negative regulator of LPS-induced inflammation in the microglial cell line BV-2. Larson KC, et al. Inflamm Res, 2010 Jan. PMID 19568691
  3. Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. Morishita R, et al. J Neurochem, 1997 Feb. PMID 9003074
  4. Distribution of heterotrimeric G-protein beta and gamma subunits in the rat brain. Betty M, et al. Neuroscience, 1998 Jul. PMID 9622245
  5. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphate ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
 PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
Names
guanine nucleotide binding protein (G protein), gamma 12
heterotrimeric guanine nucleotide-binding protein 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053661.1 → NP_446113.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12

    See identical proteins and their annotated locations for NP_446113.1

    Status: VALIDATED

    Source sequence(s)
    BG378509, FM031435
    UniProtKB/TrEMBL
    A6KF41, G3V6P8
    Related
    ENSRNOP00000067190.1, ENSRNOT00000075400.3
    Conserved Domains (1) summary
    smart00224
    Location:12 → 72
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    97340830..97464422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063285384.1 → XP_063141454.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/TrEMBL
    A6KF41, G3V6P8

  2. XM_039106904.2 → XP_038962832.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/TrEMBL
    A6KF41, G3V6P8
    Conserved Domains (1) summary
    smart00224
    Location:12 → 72
    GGL; G protein gamma subunit-like motifs

  3. XM_063285385.1 → XP_063141455.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/TrEMBL
    A6KF41, G3V6P8

  4. XM_063285387.1 → XP_063141457.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/TrEMBL
    A6KF41, G3V6P8

  5. XM_063285386.1 → XP_063141456.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 isoform X1

    UniProtKB/TrEMBL
    A6KF41, G3V6P8
Nucleotide Protein Strain
Heading Accession and Version

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